4F6S
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![BU of 4f6s by Molmil](/molmil-images/mine/4f6s) | Crystal structure of human CDK8/CYCC in complex with compound 7 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea) | 分子名称: | 1,2-ETHANEDIOL, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, Cyclin-C, ... | 著者 | Schneider, E.V, Boettcher, J, Huber, R, Maskos, K. | 登録日 | 2012-05-15 | 公開日 | 2013-05-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-kinetic relationship study of CDK8/CycC specific compounds. Proc.Natl.Acad.Sci.USA, 110, 2013
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6R7W
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![BU of 6r7w by Molmil](/molmil-images/mine/6r7w) | Tannerella forsythia mature mirolysin in complex with a cleaved peptide. | 分子名称: | CALCIUM ION, CITRIC ACID, ETHANOL, ... | 著者 | Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X. | 登録日 | 2019-03-29 | 公開日 | 2019-11-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases. Iucrj, 7, 2020
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4FHJ
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![BU of 4fhj by Molmil](/molmil-images/mine/4fhj) | Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2 | 分子名称: | 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Shaffer, P.L, Tang, J, Yakowec, P. | 登録日 | 2012-06-06 | 公開日 | 2012-07-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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1IB8
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![BU of 1ib8 by Molmil](/molmil-images/mine/1ib8) | SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE | 分子名称: | CONSERVED PROTEIN SP14.3 | 著者 | Yu, L, Gunasekera, A.H, Mack, J, Olejniczak, E.T, Chovan, L.E, Ruan, X, Towne, D.L, Lerner, C.G, Fesik, S.W. | 登録日 | 2001-03-27 | 公開日 | 2002-03-27 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE J.Mol.Biol., 311, 2001
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6R3A
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![BU of 6r3a by Molmil](/molmil-images/mine/6r3a) | BACTERIOPHAGE SPP1 MATURE CAPSID PROTEIN | 分子名称: | Major capsid protein | 著者 | Ignatiou, A, El Sadek Fadel, M, Buerger, J, Mielke, T, Topf, M, Tavares, P. | 登録日 | 2019-03-19 | 公開日 | 2019-10-23 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural transitions during the scaffolding-driven assembly of a viral capsid. Nat Commun, 10, 2019
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1I7A
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![BU of 1i7a by Molmil](/molmil-images/mine/1i7a) | EVH1 DOMAIN FROM MURINE HOMER 2B/VESL 2 | 分子名称: | CITRATE ANION, HOMER 2B, PHE-ALA-PHE, ... | 著者 | Barzik, M, Carl, U.D, Schubert, W.-D, Wehland, J, Heinz, D.W. | 登録日 | 2001-03-08 | 公開日 | 2001-08-22 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | The N-terminal domain of Homer/Vesl is a new class II EVH1 domain. J.Mol.Biol., 309, 2001
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1HL4
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![BU of 1hl4 by Molmil](/molmil-images/mine/1hl4) | The Structure of Apo Type Human Cu, Zn Superoxide Dismutase | 分子名称: | SUPEROXIDE DISMUTASE, ZINC ION | 著者 | Strange, R.W, Antonyuk, S, Hough, M.A, Doucette, P, Rodriguez, J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | 登録日 | 2003-03-13 | 公開日 | 2003-05-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | The Structure of Holo and Metal-Deficient Wild-Type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis J.Mol.Biol., 328, 2003
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1HL5
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![BU of 1hl5 by Molmil](/molmil-images/mine/1hl5) | The Structure of Holo Type Human Cu, Zn Superoxide Dismutase | 分子名称: | CALCIUM ION, COPPER (II) ION, SUPEROXIDE DISMUTASE, ... | 著者 | Strange, R.W, Antonyuk, S, Hough, M.A, Doucette, P, Rodriguez, J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | 登録日 | 2003-03-13 | 公開日 | 2003-05-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Structure of Holo and Metal-Deficient Wild-Type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis J.Mol.Biol., 328, 2003
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1HJL
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![BU of 1hjl by Molmil](/molmil-images/mine/1hjl) | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis protein MobA | 分子名称: | CITRIC ACID, LITHIUM ION, MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A | 著者 | Guse, A, Stevenson, C.E.M, Kuper, J, Buchanan, G, Schwarz, G, Mendel, R.R, Lawson, D.M, Palmer, T. | 登録日 | 2003-02-27 | 公開日 | 2003-05-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis Protein Moba J.Biol.Chem., 278, 2003
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1HJJ
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![BU of 1hjj by Molmil](/molmil-images/mine/1hjj) | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis protein MobA | 分子名称: | CITRIC ACID, LITHIUM ION, MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A | 著者 | Guse, A, Stevenson, C.E.M, Kuper, J, Buchanan, G, Schwarz, G, Mendel, R.R, Lawson, D.M, Palmer, T. | 登録日 | 2003-02-27 | 公開日 | 2003-05-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Biochemical and Structural Analysis of the Molybdenum Cofactor Biosynthesis Protein Moba J.Biol.Chem., 278, 2003
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1IAI
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![BU of 1iai by Molmil](/molmil-images/mine/1iai) | IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX | 分子名称: | ANTI-IDIOTYPIC FAB 409.5.3 (IGG2A), IDIOTYPIC FAB 730.1.4 (IGG1) OF VIRUS NEUTRALIZING ANTIBODY | 著者 | Ban, N, Escobar, C, Garcia, R, Hasel, K, Day, J, Greenwood, A, McPherson, A. | 登録日 | 1993-12-28 | 公開日 | 1996-03-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of an idiotype-anti-idiotype Fab complex. Proc.Natl.Acad.Sci.USA, 91, 1994
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7CTG
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![BU of 7ctg by Molmil](/molmil-images/mine/7ctg) | Human Origin Recognition Complex, ORC1-5 State I | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | 著者 | Cheng, J, Li, N, Wang, X, Hu, J, Zhai, Y, Gao, N. | 登録日 | 2020-08-18 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Structural insight into the assembly and conformational activation of human origin recognition complex. Cell Discov, 6, 2020
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7C88
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![BU of 7c88 by Molmil](/molmil-images/mine/7c88) | Complex structure of JS003 and PD-L1 | 分子名称: | JS003 Heavy chain, JS003 Light chain, Programmed cell death 1 ligand 1 | 著者 | Bi, X, Shi, R, Chai, Y, Qi, J, Yan, J, Tan, S. | 登録日 | 2020-05-29 | 公開日 | 2021-04-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy. Signal Transduct Target Ther, 5, 2020
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7C6P
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![BU of 7c6p by Molmil](/molmil-images/mine/7c6p) | Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid | 分子名称: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4 | 著者 | Li, J, Yu, K, Luo, Y, Zheng, W, Liang, W, Zhu, J. | 登録日 | 2020-05-22 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
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7C2Z
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![BU of 7c2z by Molmil](/molmil-images/mine/7c2z) | Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone | 分子名称: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4, FORMIC ACID | 著者 | Li, J, Zhu, J. | 登録日 | 2020-05-10 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
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7C3V
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![BU of 7c3v by Molmil](/molmil-images/mine/7c3v) | Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) | 分子名称: | Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Dai, W, Ni, Y, Xu, G, Liu, Y, Wang, Y, Zhou, J. | 登録日 | 2020-05-14 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.20042944 Å) | 主引用文献 | Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) To Be Published
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7CFP
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![BU of 7cfp by Molmil](/molmil-images/mine/7cfp) | |
7CFQ
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![BU of 7cfq by Molmil](/molmil-images/mine/7cfq) | Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... | 著者 | Zhao, J, Zhang, X, Zang, J. | 登録日 | 2020-06-27 | 公開日 | 2021-07-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
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7CKK
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![BU of 7ckk by Molmil](/molmil-images/mine/7ckk) | Structural complex of FTO bound with Dac51 | 分子名称: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | 著者 | Yang, C, Gan, J. | 登録日 | 2020-07-17 | 公開日 | 2021-07-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab., 33, 2021
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7DL2
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![BU of 7dl2 by Molmil](/molmil-images/mine/7dl2) | Cryo-EM structure of human TSC complex | 分子名称: | Hamartin, Isoform 7 of Tuberin, TBC1 domain family member 7, ... | 著者 | Yang, H, Yu, Z, Chen, X, Li, J, Li, N, Cheng, J, Gao, N, Yuan, H, Ye, D, Guan, K, Xu, Y. | 登録日 | 2020-11-25 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural insights into TSC complex assembly and GAP activity on Rheb. Nat Commun, 12, 2021
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7DPM
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![BU of 7dpm by Molmil](/molmil-images/mine/7dpm) | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | 登録日 | 2020-12-20 | 公開日 | 2021-02-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.304 Å) | 主引用文献 | Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV. Mabs, 13, 2021
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7CXY
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![BU of 7cxy by Molmil](/molmil-images/mine/7cxy) | Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (zinc-bound form) | 分子名称: | Carbonic anhydrase, ZINC ION | 著者 | Jin, M.S, Kim, S, Yeon, J, Sung, J, Kim, N.J, Hong, S. | 登録日 | 2020-09-02 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus. J.Struct.Biol., 213, 2021
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7CXW
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![BU of 7cxw by Molmil](/molmil-images/mine/7cxw) | Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (C116 flipped form) | 分子名称: | ACETATE ION, Carbonic anhydrase | 著者 | Jin, M.S, Kim, S, Yeon, J, Sung, J, Kim, N.J, Hong, S. | 登録日 | 2020-09-02 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus. J.Struct.Biol., 213, 2021
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7CXX
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![BU of 7cxx by Molmil](/molmil-images/mine/7cxx) | Structural insights into novel mechanisms of inhibition of the major b-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus (disulfide-bonded form) | 分子名称: | ACETATE ION, Carbonic anhydrase, SULFATE ION | 著者 | Jin, M.S, Kim, S, Yeon, J, Sung, J, Kim, N.J, Hong, S. | 登録日 | 2020-09-02 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into novel mechanisms of inhibition of the major beta-carbonic anhydrase CafB from the pathogenic fungus Aspergillus fumigatus. J.Struct.Biol., 213, 2021
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6X3X
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![BU of 6x3x by Molmil](/molmil-images/mine/6x3x) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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