7SW4
 
 | | MicroED structure of proteinase K from a 540 nm thick lamella measured at 200 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.4 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8Q1A
 | | The Crystal Structure of Human Carbonic Anhydrase IX in Complex with inhibitor | | 分子名称: | 1,1,3-tris(oxidanylidene)-2-pentyl-1,2-benzothiazole-6-sulfonamide, Carbonic anhydrase 9, GLYCEROL, ... | | 著者 | Leitans, J, Tars, K. | | 登録日 | 2023-07-31 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX.
Chemmedchem, 18, 2023
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7SW9
 | | MicroED structure of proteinase K from a 170 nm thick lamella measured at 300 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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3IZH
 | | Mm-cpn D386A with ATP | | 分子名称: | Chaperonin | | 著者 | Douglas, N.R, Reissmann, S, Zhang, J, Chen, B, Jakana, J, Kumar, R, Chiu, W, Frydman, J. | | 登録日 | 2010-10-29 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (11 Å) | | 主引用文献 | Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber.
Cell(Cambridge,Mass.), 144, 2011
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6PIZ
 | | Crystal structure of HCV NS3/4A D168A protease in complex with P4-1 (NR02-24) | | 分子名称: | 1,2-ETHANEDIOL, 1-methylcyclopropyl [(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]carbamate, GLYCEROL, ... | | 著者 | Zephyr, J, Schiffer, C.A. | | 登録日 | 2019-06-27 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
Mbio, 11, 2020
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8BO6
 | | COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR 2 | | 分子名称: | (~{E})-~{N}-[[5-(3-azanyl-1~{H}-indazol-6-yl)-4-chloranyl-1~{H}-imidazol-2-yl]methyl]-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enamide, CITRIC ACID, Coagulation factor XIa light chain, ... | | 著者 | Schaefer, M, Roehrig, S, Ackerstaff, J, Nunez, E.J, Gericke, K.M, Meier, K, Tersteegen, A, Stampfuss, J, Ellerbrock, P, Meibom, D, Lang, D, Heitmeier, S, Hillisch, A. | | 登録日 | 2022-11-14 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.
J.Med.Chem., 66, 2023
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6P5K
 | | Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3) | | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | | 著者 | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | | 登録日 | 2019-05-30 | | 公開日 | 2019-09-18 | | 最終更新日 | 2020-01-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38, 2019
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7SVY
 | | MicroED structure of proteinase K from a 130 nm thick lamella measured at 120 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.3 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8BO7
 | | COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR 34 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[[(2~{S})-2-[4-(5-chloranyl-2-cyano-phenyl)-3-methoxy-6-oxidanylidene-2,5-dihydropyridin-1-yl]-3-[(2~{S})-oxan-2-yl]propanoyl]amino]benzoic acid, CITRIC ACID, ... | | 著者 | Schaefer, M, Roehrig, S, Ackerstaff, J, Nunez, E.J, Gericke, K.M, Meier, K, Tersteegen, A, Stampfuss, J, Ellerbrock, P, Meibom, D, Lang, D, Heitmeier, S, Hillisch, A. | | 登録日 | 2022-11-14 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.
J.Med.Chem., 66, 2023
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7SWB
 | | MicroED structure of proteinase K from a 360 nm thick lamella measured at 300 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.05 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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3IZM
 | | Mm-cpn wildtype with ATP | | 分子名称: | Chaperonin | | 著者 | Douglas, N.R, Reissmann, S, Zhang, J, Chen, B, Jakana, J, Kumar, R, Chiu, W, Frydman, J. | | 登録日 | 2010-10-30 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber.
Cell(Cambridge,Mass.), 144, 2011
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7SW2
 | | MicroED structure of proteinase K from a 130 nm thick lamella measured at 200 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.95 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7SW8
 | | MicroED structure of proteinase K from a 150 nm thick lamella measured at 300 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.9 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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3IYF
 | | Atomic Model of the Lidless Mm-cpn in the Open State | | 分子名称: | Chaperonin | | 著者 | Zhang, J, Baker, M.L, Schroeder, G, Douglas, N.R, Reissmann, S, Jakana, J, Dougherty, M, Fu, C.J, Levitt, M, Ludtke, S.J, Frydman, J, Chiu, W. | | 登録日 | 2009-10-23 | | 公開日 | 2010-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | Mechanism of folding chamber closure in a group II chaperonin
Nature, 463, 2010
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6PD1
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3IZL
 | | Mm-cpn rls deltalid with ATP and AlFx | | 分子名称: | Mm-cpn rls deltalid | | 著者 | Douglas, N.R, Reissmann, S, Zhang, J, Chen, B, Jakana, J, Kumar, R, Chiu, W, Frydman, J. | | 登録日 | 2010-10-29 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber.
Cell(Cambridge,Mass.), 144, 2011
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3IZN
 | | Mm-cpn deltalid with ATP | | 分子名称: | Chaperonin | | 著者 | Douglas, N.R, Reissmann, S, Zhang, J, Chen, B, Jakana, J, Kumar, R, Chiu, W, Frydman, J. | | 登録日 | 2010-10-30 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber.
Cell(Cambridge,Mass.), 144, 2011
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3J03
 | | Lidless Mm-cpn in the closed state with ATP/AlFx | | 分子名称: | Lidless Mm-cpn | | 著者 | Zhang, J, Ma, B, DiMaio, F, Douglas, N.R, Joachimiak, L, Baker, D, Frydman, J, Levitt, M, Chiu, W. | | 登録日 | 2011-02-10 | | 公開日 | 2011-05-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure.
Structure, 19, 2011
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3IZK
 | | Mm-cpn rls deltalid with ATP | | 分子名称: | Chaperonin | | 著者 | Douglas, N.R, Reissmann, S, Zhang, J, Chen, B, Jakana, J, Kumar, R, Chiu, W, Frydman, J. | | 登録日 | 2010-10-29 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber.
Cell(Cambridge,Mass.), 144, 2011
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7SW5
 | | MicroED structure of proteinase K from a 460 nm thick lamella measured at 200 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.95 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6PGI
 | | Asymmetric functions of a binuclear metal cluster within the transport pathway of the ZIP transition metal transporters | | 分子名称: | BbZIP, CADMIUM ION | | 著者 | Zhang, T, Sui, D, Zhang, C, Logan, T, Hu, J. | | 登録日 | 2019-06-24 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.
Faseb J., 34, 2020
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5ED3
 | | crystal structure of human Hint1 complexing with AP5A | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1 | | 著者 | Wang, J, Fang, P, Guo, M. | | 登録日 | 2015-10-20 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.309 Å) | | 主引用文献 | Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells.
Nat Commun, 10, 2019
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7SVZ
 | | MicroED structure of proteinase K from a 200 nm thick lamella measured at 120 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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4Z8V
 | | CRYSTAL STRUCTURE OF AVRRXO1-ORF1:-ORF2 COMPLEX, NATIVE. | | 分子名称: | AvrRxo1-ORF1, AvrRxo1-ORF2, PHOSPHATE ION | | 著者 | Han, Q, Zhou, C, Wu, S, Liu, Y, Yang, Z, Miao, J, Triplett, L, Cheng, Q, Tokuhisa, J, Deblais, L, Robinson, H, Leach, J.E, Li, J, Zhao, B. | | 登録日 | 2015-04-09 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Xanthomonas AvrRxo1-ORF1, a Type III Effector with a Polynucleotide Kinase Domain, and Its Interactor AvrRxo1-ORF2.
Structure, 23, 2015
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7SW6
 | | MicroED structure of proteinase K from a 260 nm thick lamella measured at 200 kV | | 分子名称: | Proteinase K | | 著者 | Martynowycz, M.W, Clabbers, M.T.B, Unge, J, Hattne, J, Gonen, T. | | 登録日 | 2021-11-19 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.95 Å) | | 主引用文献 | Benchmarking the ideal sample thickness in cryo-EM.
Proc.Natl.Acad.Sci.USA, 118, 2021
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