4O02
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![BU of 4o02 by Molmil](/molmil-images/mine/4o02) | AlphaVBeta3 integrin in complex with monoclonal antibody FAB fragment. | Descriptor: | 17E6 heavy chain, 17E6 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mahalingam, B, van Agthoven, J, Xiong, J, Arnaout, M.A. | Deposit date: | 2013-12-13 | Release date: | 2014-04-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.605 Å) | Cite: | Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex. J.Biol.Chem., 289, 2014
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4O0C
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![BU of 4o0c by Molmil](/molmil-images/mine/4o0c) | High resolution crystal structure of uncleaved human L-asparaginase protein | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, Isoaspartyl peptidase/L-asparaginase, ... | Authors: | Nomme, J, Lavie, A. | Deposit date: | 2013-12-13 | Release date: | 2014-04-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis. J.Mol.Biol., 426, 2014
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5DLL
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![BU of 5dll by Molmil](/molmil-images/mine/5dll) | Aminopeptidase N (pepN) from Francisella tularensis subsp. tularensis SCHU S4 | Descriptor: | Aminopeptidase N, CHLORIDE ION, PHOSPHATE ION, ... | Authors: | Borek, D, Raczynska, J, Dubrovska, I, Grimshaw, S, Minasov, G, Shuvalova, L, Kwon, K, Anderson, W.F, Otwinowski, Z, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2015-09-07 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Aminopeptidase N (pepN) from Francisella tularensis subsp. tularensis SCHU S4 To Be Published
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7CPX
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![BU of 7cpx by Molmil](/molmil-images/mine/7cpx) | Lovastatin nonaketide synthase | Descriptor: | Lovastatin nonaketide synthase, polyketide synthase component, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wang, J, Wang, Z. | Deposit date: | 2020-08-08 | Release date: | 2021-01-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Structural basis for the biosynthesis of lovastatin. Nat Commun, 12, 2021
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4O0N
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![BU of 4o0n by Molmil](/molmil-images/mine/4o0n) | 2.4 Angstrom Resolution Crystal Structure of Putative Nucleoside Diphosphate Kinase from Toxoplasma gondii. | Descriptor: | Nucleoside diphosphate kinase, SULFATE ION | Authors: | Minasov, G, Ruan, J, Ngo, H, Shuvalova, L, Dubrovska, I, Flores, K, Shanmugam, D, Roos, D, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-12-13 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii . Front Cell Infect Microbiol, 8, 2018
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4O2R
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![BU of 4o2r by Molmil](/molmil-images/mine/4o2r) | Structure of Mus musculus Rheb G63V mutant bound to GDP | Descriptor: | GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M. | Deposit date: | 2013-12-17 | Release date: | 2014-03-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289, 2014
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4O06
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![BU of 4o06 by Molmil](/molmil-images/mine/4o06) | 1.15A Resolution Structure of the Proteasome Assembly Chaperone Nas2 PDZ Domain | Descriptor: | Probable 26S proteasome regulatory subunit p27, SULFATE ION, TETRAETHYLENE GLYCOL | Authors: | Lovell, S, Mehzabeen, N, Battaile, K.P, Singh, C.R, Chowdhury, W.Q, Geanes, E, Roelofs, J. | Deposit date: | 2013-12-13 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | 1.15 angstrom resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain. Acta Crystallogr F Struct Biol Commun, 70, 2014
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4O0G
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![BU of 4o0g by Molmil](/molmil-images/mine/4o0g) | Crystal structure of the human L-asparaginase protein T219V mutant | Descriptor: | Isoaspartyl peptidase/L-asparaginase, SODIUM ION | Authors: | Nomme, J, Lavie, A. | Deposit date: | 2013-12-13 | Release date: | 2014-04-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis. J.Mol.Biol., 426, 2014
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4O61
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![BU of 4o61 by Molmil](/molmil-images/mine/4o61) | Structure of human ALKBH5 crystallized in the presence of citrate | Descriptor: | CITRIC ACID, GLYCEROL, RNA demethylase ALKBH5, ... | Authors: | Tempel, W, Chao, X, Liu, K, Dong, A, Cerovina, T, He, H, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2013-12-20 | Release date: | 2014-02-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. J.Biol.Chem., 289, 2014
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4O4A
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![BU of 4o4a by Molmil](/molmil-images/mine/4o4a) | 2.75 Angstrom Crystal Structure of Putative Lipoprotein from Bacillus anthracis. | Descriptor: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Lipoprotein, ... | Authors: | Minasov, G, Halavaty, A, Shuvalova, L, Winsor, J, Dubrovska, I, Shatsman, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-12-18 | Release date: | 2014-01-01 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | 2.75 Angstrom Crystal Structure of Putative Lipoprotein from Bacillus anthracis. TO BE PUBLISHED
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7CRW
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![BU of 7crw by Molmil](/molmil-images/mine/7crw) | Cryo-EM structure of rNLRP1-rDPP9 complex | Descriptor: | Dipeptidyl peptidase 9, NLR family protein 1 | Authors: | Huang, M.H, Zhang, X.X, Wang, J, Chai, J.J. | Deposit date: | 2020-08-14 | Release date: | 2021-03-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Nature, 592, 2021
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7CRV
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![BU of 7crv by Molmil](/molmil-images/mine/7crv) | |
5E1M
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![BU of 5e1m by Molmil](/molmil-images/mine/5e1m) | Crystal structure of NTMT1 in complex with PPKRIA peptide | Descriptor: | GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ... | Authors: | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-09-29 | Release date: | 2015-10-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for substrate recognition by the human N-terminal methyltransferase 1. Genes Dev., 29, 2015
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5E2A
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![BU of 5e2a by Molmil](/molmil-images/mine/5e2a) | Crystal structure of NTMT1 in complex with N-terminally methylated SPKRIA peptide | Descriptor: | GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ... | Authors: | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2015-09-30 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for substrate recognition by the human N-terminal methyltransferase 1. Genes Dev., 29, 2015
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4O2B
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![BU of 4o2b by Molmil](/molmil-images/mine/4o2b) | Tubulin-Colchicine complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O. | Deposit date: | 2013-12-17 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426, 2014
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5E3G
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![BU of 5e3g by Molmil](/molmil-images/mine/5e3g) | Crystal structure of the human BRPF1 bromodomain in complex with SEED8 | Descriptor: | 2-thioxo-2,3,7,9-tetrahydro-1H-purine-6,8-dione, NITRATE ION, Peregrin | Authors: | Zhu, J, Caflisch, A. | Deposit date: | 2015-10-02 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions. J.Med.Chem., 59, 2016
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7CE2
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![BU of 7ce2 by Molmil](/molmil-images/mine/7ce2) | The Crystal structure of TeNT Hc complexed with neutralizing antibody | Descriptor: | Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain | Authors: | Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H. | Deposit date: | 2020-06-21 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural basis of tetanus toxin neutralization by native human monoclonal antibodies. Cell Rep, 35, 2021
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5E8N
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![BU of 5e8n by Molmil](/molmil-images/mine/5e8n) | The structure of the TEIPP associated Trh4 peptide in complex with H-2D(b) | Descriptor: | Beta-2-microglobulin, Ceramide synthase 5, GLYCEROL, ... | Authors: | Hafstrand, I, Doorduijn, E, Duru, A.D, Buratto, J, Oliveira, C.C, Sandalova, T, van Hall, T, Achour, A. | Deposit date: | 2015-10-14 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer. J Immunol., 196, 2016
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5DU3
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![BU of 5du3 by Molmil](/molmil-images/mine/5du3) | Active form of human C1-inhibitor | Descriptor: | Plasma protease C1 inhibitor | Authors: | Pannu, N.S, Dijk, M, Holkers, J, Voskamp, P, Giannetti, B.M, Waterreus, W.J, van Veen, H.A. | Deposit date: | 2015-09-18 | Release date: | 2016-08-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation. Structure, 24, 2016
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6DW4
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![BU of 6dw4 by Molmil](/molmil-images/mine/6dw4) | SAMHD1 Bound to Cladribine-TP in the Catalytic Pocket and Allosteric Pocket | Descriptor: | 2'-deoxy-2-methyladenosine 5'-(tetrahydrogen triphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Knecht, K.M, Buzovetsky, O, Schneider, C, Thomas, D, Srikanth, V, Kaderali, L, Tofoleanu, F, Reiss, K, Ferreiros, N, Geisslinger, G, Batista, V.S, Ji, X, Cinatl, J, Keppler, O.T, Xiong, Y. | Deposit date: | 2018-06-26 | Release date: | 2018-10-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4OAV
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![BU of 4oav by Molmil](/molmil-images/mine/4oav) | Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate. | Descriptor: | (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-2-({[(S)-hydroxy{[(2R,3S,4S)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy}phosphoryl]oxy}methyl)tetrahydrofuran-3-yl dihydrogen phosphate, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Han, Y, Donovan, J, Rath, S, Whitney, G, Chitrakar, A, Korennykh, A. | Deposit date: | 2014-01-06 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science, 343, 2014
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4OCS
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![BU of 4ocs by Molmil](/molmil-images/mine/4ocs) | Crystal structure of human Fab CAP256-VRC26.10, a potent V1V2-directed HIV-1 neutralizing antibody | Descriptor: | CAP256-VRC26.10 heavy chain, CAP256-VRC26.10 light chain | Authors: | Gorman, J, Doria-Rose, N.A, Schramm, C.A, Moore, P.L, Mascola, J.R, Shapiro, L, Morris, L, Kwong, P.D. | Deposit date: | 2014-01-09 | Release date: | 2014-02-26 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature, 509, 2014
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5DUP
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![BU of 5dup by Molmil](/molmil-images/mine/5dup) | Influenza A virus H5 hemagglutinin globular head in complex with antibody AVFluIgG03 | Descriptor: | AVFluIgG03 Heavy Chain, AVFluIgG03 Light Chain, Hemagglutinin | Authors: | Zuo, T, Sun, J, Wang, G, Zhou, P, Wang, X, Zhang, L. | Deposit date: | 2015-09-20 | Release date: | 2015-12-16 | Method: | X-RAY DIFFRACTION (3.052 Å) | Cite: | Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection Nat Commun, 6, 2015
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4OL4
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![BU of 4ol4 by Molmil](/molmil-images/mine/4ol4) | Crystal structure of secreted proline rich antigen MTC28 (Rv0040c) from Mycobacterium tuberculosis | Descriptor: | Proline-rich 28 kDa antigen | Authors: | Kundu, P, Biswas, R, Mukherjee, S, Reinhard, L, Mueller-dieckmann, J, Weiss, M.S, Das, A.K. | Deposit date: | 2014-01-23 | Release date: | 2015-01-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based Epitope Mapping of Mycobacterium tuberculosis Secretary Antigen MTC28 J.Biol.Chem., 291, 2016
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5EBG
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![BU of 5ebg by Molmil](/molmil-images/mine/5ebg) | Crystal structure of bovine CD8aa homodimer | Descriptor: | T-cell surface glycoprotein CD8 alpha chain | Authors: | Liu, Y, Li, X, Zhang, N, Qi, J, Xia, C. | Deposit date: | 2015-10-19 | Release date: | 2016-09-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structural basis of chicken, swine and bovine CD8 alpha alpha dimers provides insight into the co-evolution with MHC I in endotherm species. Sci Rep, 6, 2016
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