1V33
 
 | | Crystal structure of DNA primase from Pyrococcus horikoshii | | 分子名称: | DNA primase small subunit, PHOSPHATE ION, ZINC ION | | 著者 | Ito, N, Nureki, O, Shirouzu, M, Yokoyama, S, Hanaoka, F, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-10-25 | | 公開日 | 2004-03-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.
Genes Cells, 8, 2003
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1V34
 | | Crystal structure of Pyrococcus horikoshii DNA primase-UTP complex | | 分子名称: | DNA primase small subunit, URIDINE 5'-TRIPHOSPHATE, ZINC ION | | 著者 | Ito, N, Nureki, O, Shirouzu, M, Yokoyama, S, Hanaoka, F, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-10-25 | | 公開日 | 2004-03-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.
Genes Cells, 8, 2003
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5XQW
 | | Catalytic antibody 7B9 | | 分子名称: | Fab fragment of catalytic antibody 7B9, heavy chain, light chain, ... | | 著者 | Ito, N, Fujii, I, Tsumuraya, T. | | 登録日 | 2017-06-07 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis of the broad substrate tolerance of the antibody 7B9-catalyzed hydrolysis of p-nitrobenzyl esters.
Bioorg. Med. Chem., 26, 2018
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2Z8H
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1GOH
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1GOG
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1GOF
 | | NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE | | 分子名称: | ACETIC ACID, COPPER (II) ION, GALACTOSE OXIDASE, ... | | 著者 | Ito, N, Phillips, S.E.V, Knowles, P.F. | | 登録日 | 1993-09-30 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase.
Nature, 350, 1991
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7E0D
 | | Structure of L-glutamate oxidase R305E mutant in complex with L-arginine | | 分子名称: | ARGININE, FLAVIN-ADENINE DINUCLEOTIDE, L-glutamate oxidase | | 著者 | Ito, N, Matsuo, S, Inagaki, K, Imada, K. | | 登録日 | 2021-01-27 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A new l-arginine oxidase engineered from l-glutamate oxidase.
Protein Sci., 30, 2021
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7E0C
 | | Structure of L-glutamate oxidase R305E mutant | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, L-glutamate oxidase | | 著者 | Ito, N, Matsuo, S, Inagaki, K, Imada, K. | | 登録日 | 2021-01-27 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | A new l-arginine oxidase engineered from l-glutamate oxidase.
Protein Sci., 30, 2021
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7D4C
 | | Structure of L-lysine oxidase precursor | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, L-Lysine alpha-oxidase, PHOSPHATE ION | | 著者 | Ito, N, Kitagawa, M, Matsumoto, Y, Inagaki, K, Imada, K. | | 登録日 | 2020-09-23 | | 公開日 | 2021-02-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural basis of enzyme activity regulation by the propeptide of l-lysine alpha-oxidase precursor from Trichoderma viride .
J Struct Biol X, 5, 2021
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1HBH
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2DLA
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3VYC
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8YTN
 | | Single-chain Fv antibody of E11 | | 分子名称: | GLYCEROL, Single-chain Fv antibody of E11 | | 著者 | Yoshida, M, Hanazono, Y, Numoto, N, Ito, N, Oda, M. | | 登録日 | 2024-03-26 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Affinity-matured antibody with a disulfide bond in H-CDR3 loop.
Arch.Biochem.Biophys., 758, 2024
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8YTO
 | | Single-chain Fv antibody of E11 complex with NP-glycine | | 分子名称: | 2-[2-(3-nitro-4-oxidanyl-phenyl)ethanoylamino]ethanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | | 著者 | Yoshida, M, Hanazono, Y, Numoto, N, Ito, N, Oda, M. | | 登録日 | 2024-03-26 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | | 主引用文献 | Affinity-matured antibody with a disulfide bond in H-CDR3 loop.
Arch.Biochem.Biophys., 758, 2024
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8YTP
 | | Single-chain Fv antibody of E11 complex with NP-glycine under reducing conditions | | 分子名称: | 2-[2-(3-nitro-4-oxidanyl-phenyl)ethanoylamino]ethanoic acid, Single-chain Fv antibody of E11 | | 著者 | Yoshida, M, Hanazono, Y, Numoto, N, Ito, N, Oda, M. | | 登録日 | 2024-03-26 | | 公開日 | 2024-07-03 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Affinity-matured antibody with a disulfide bond in H-CDR3 loop.
Arch.Biochem.Biophys., 758, 2024
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6LCA
 | | Crystal structure of human Dishevelled1 PDZ domain homotrimer | | 分子名称: | SULFATE ION, Segment polarity protein dishevelled homolog DVL-1 | | 著者 | Yasukochi, S, Numoto, N, Tenno, N, Tenno, T, Ito, N, Hiroaki, H. | | 登録日 | 2019-11-18 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of human Dishevelled1 PDZ domain homotrimer
To Be Published
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6L6K
 | | Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1 | | 分子名称: | 1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic acid, CALCIUM ION, Nuclear receptor coactivator 1, ... | | 著者 | Shimizu, K, Numoto, N, Nakano, S, Makishima, M, Kakuta, H, Ito, N. | | 登録日 | 2019-10-29 | | 公開日 | 2020-11-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of dimeric RXRalpha-LBD complexed with partial agonist CBt-PMN and SRC1
To Be Published
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6LB4
 | | Crystal structure of dimeric RXR-LBD complexed with NEt-3ME and TIF2 co-activator | | 分子名称: | 1,2-ETHANEDIOL, 6-[ethyl-[3-(2-methoxyethoxy)-4-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid, Nuclear receptor coactivator 2, ... | | 著者 | Imai, D, Numoto, N, Nakano, S, Kakuta, H, Ito, N. | | 登録日 | 2019-11-13 | | 公開日 | 2020-11-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of dimeric RXR-LBD complexed with NEt-3ME and TIF2 co-activator
To Be Published
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6LB6
 | | Crystal structure of dimeric RXR-LBD complexed with partial agonist NEt-4IB and TIF2 co-activator | | 分子名称: | 6-[ethyl-[4-(2-methylpropoxy)-3-propan-2-yl-phenyl]amino]pyridine-3-carboxylic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | | 著者 | Imai, D, Numoto, N, Nakano, S, Kakuta, H, Ito, N. | | 登録日 | 2019-11-13 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for the full and partial agonist activities of retinoid X receptor alpha ligands with an iso-butoxy and an isopropyl group
Biochem.Biophys.Res.Commun., 734, 2024
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4WUA
 | | Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340 | | 分子名称: | CITRIC ACID, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide, SRSF protein kinase 1, ... | | 著者 | Hoshina, M, Ikura, T, Hosoya, T, Hagiwara, M, Ito, N. | | 登録日 | 2014-10-31 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Mol.Pharmacol., 88, 2015
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4X42
 | | Crystal structure of DEN4 ED3 mutant with epitope two residues substituted from DEN3 ED3 | | 分子名称: | Envelope protein E, SULFATE ION | | 著者 | Kulkarni, M.R, Islam, M.M, Numoto, N, Elahi, M.M, Ito, N, Kuroda, Y. | | 登録日 | 2014-12-02 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Structural and biophysical analysis of sero-specific immune responses using epitope grafted Dengue ED3 mutants.
Biochim.Biophys.Acta, 1854, 2015
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5ZQU
 | | Crystal structure of tetrameric RXRalpha-LBD complexed with partial agonist CBt-PMN | | 分子名称: | 1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)benzotriazole-5-carboxylic acid, BROMIDE ION, Retinoic acid receptor RXR-alpha | | 著者 | Miyashita, Y, Numoto, N, Arulmozhiraja, S, Nakano, S, Matsuo, N, Shimizu, K, Kakuta, H, Ito, S, Ikura, T, Ito, N, Tokiwa, H. | | 登録日 | 2018-04-20 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.60038781 Å) | | 主引用文献 | Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor alpha (RXR alpha ).
FEBS Lett., 593, 2019
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1URN
 | | U1A MUTANT/RNA COMPLEX + GLYCEROL | | 分子名称: | CHLORIDE ION, GLYCEROL, PROTEIN (U1A), ... | | 著者 | Oubridge, C, Ito, N, Evans, P.R, Teo, C.-H, Nagai, K. | | 登録日 | 1995-01-04 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.
Nature, 372, 1994
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1X1U
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