4WUA

Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340

Summary for 4WUA

Entry DOI	10.2210/pdb4wua/pdb
Descriptor	SRSF protein kinase 1, linker, SRSF protein kinase 1, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide, CITRIC ACID, ... (4 entities in total)
Functional Keywords	protein kinase, kinase-inhibitor complex, pre-mrna splicing, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	46180.54
Authors	Hoshina, M.,Ikura, T.,Hosoya, T.,Hagiwara, M.,Ito, N. (deposition date: 2014-10-31, release date: 2015-09-16, Last modification date: 2023-11-08)
Primary citation	Morooka, S.,Hoshina, M.,Kii, I.,Okabe, T.,Kojima, H.,Inoue, N.,Okuno, Y.,Denawa, M.,Yoshida, S.,Fukuhara, J.,Ninomiya, K.,Ikura, T.,Furuya, T.,Nagano, T.,Noda, K.,Ishida, S.,Hosoya, T.,Ito, N.,Yoshimura, N.,Hagiwara, M. Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice Mol.Pharmacol., 88:316-325, 2015 Cited by PubMed: 25993998 DOI: 10.1124/mol.114.097345 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation