4WUA

Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 3UL A 701

Chain	Residue
A	LEU86
A	TYR227
A	HOH834
A	VAL145
A	PHE165
A	GLU166
A	VAL167
A	LEU168
A	GLY169
A	LEU220
A	VAL223

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site_id	AC2
Number of Residues	6
Details	binding site for residue CIT A 702

Chain	Residue
A	ARG515
A	ARG515
A	ARG518
A	ARG518
A	ARG561
A	ARG561

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGWGHFSTVWlSwdiqgkkf..........VAMK

Chain	Residue	Details
A	LEU86-LYS109

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHtDIKpeNILL

Chain	Residue	Details
A	ILE209-LEU221

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16209947","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CK2","evidences":[{"source":"PubMed","id":"12565829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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