4WUA
Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | SRSF protein kinase 1, linker, SRSF protein kinase 1 | polymer | 401 | 45639.1 | 1 | UniProt (Q96SB4) Pfam (PF00069) In PDB | Homo sapiens (Human) | SFRS protein kinase 1,Serine/arginine-rich protein-specific kinase 1,SR-protein-specific kinase 1 |
| 2 | A | N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide | non-polymer | 349.4 | 1 | Chemie (3UL) | |||
| 3 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 4 | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A: 42 - 472 (UniProt: Q96SB4)
A: 474 - 655 (UniProt: Q96SB4)
| PDB | External Database | Details |
|---|---|---|
| Gly 38 | - | expression tag |
| Ser 39 | - | expression tag |
| His 40 | - | expression tag |
| Met 41 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 473 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45639.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 541.5 | |
| All* | Total formula weight | 46180.5 |
