5Z14
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![BU of 5z14 by Molmil](/molmil-images/mine/5z14) | Crystal structure of human TLR8 in complex with CU-CPT9a | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2017-12-25 | 公開日 | 2018-07-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State To Be Published
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3A57
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![BU of 3a57 by Molmil](/molmil-images/mine/3a57) | Crystal structure of Thermostable Direct Hemolysin | 分子名称: | Thermostable direct hemolysin 2 | 著者 | Hashimoto, H, Yanagihara, I, Nakahira, K, Hamada, D, Ikegami, T, Mayanagi, K, Kaieda, S, Fukui, T, Ohnishi, K, Kajiyama, S, Yamane, T, Ikeguchi, M, Honda, T, Shimizu, T, Sato, M. | 登録日 | 2009-08-03 | 公開日 | 2010-03-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin J.Biol.Chem., 285, 2010
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5ZSC
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![BU of 5zsc by Molmil](/molmil-images/mine/5zsc) | Crystal structure of monkey TLR7 in complex with IMDQ and CCUUCC | 分子名称: | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2018-04-28 | 公開日 | 2019-01-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Rep, 25, 2018
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3ABD
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![BU of 3abd by Molmil](/molmil-images/mine/3abd) | Structure of human REV7 in complex with a human REV3 fragment in a monoclinic crystal | 分子名称: | DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B | 著者 | Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M. | 登録日 | 2009-12-07 | 公開日 | 2010-02-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase {zeta} and REV1 J.Biol.Chem., 285, 2010
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2Z5N
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![BU of 2z5n by Molmil](/molmil-images/mine/2z5n) | Complex of Transportin 1 with hnRNP D NLS | 分子名称: | Heterogeneous nuclear ribonucleoprotein D0, Transportin-1 | 著者 | Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M. | 登録日 | 2007-07-14 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for substrate recognition and dissociation by human transportin 1 Mol.Cell, 28, 2007
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3A8R
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![BU of 3a8r by Molmil](/molmil-images/mine/3a8r) | The structure of the N-terminal regulatory domain of a plant NADPH oxidase | 分子名称: | CALCIUM ION, Putative uncharacterized protein | 著者 | Oda, T, Hashimoto, H, Kuwabara, N, Akashi, S, Hayashi, K, Kojima, C, Wong, H.L, Kawasaki, T, Shimamoto, K, Sato, M, Shimizu, T. | 登録日 | 2009-10-07 | 公開日 | 2009-10-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications J.Biol.Chem., 285, 2010
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3ABE
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![BU of 3abe by Molmil](/molmil-images/mine/3abe) | Structure of human REV7 in complex with a human REV3 fragment in a tetragonal crystal | 分子名称: | DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B | 著者 | Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M. | 登録日 | 2009-12-07 | 公開日 | 2010-02-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase {zeta} and REV1 J.Biol.Chem., 285, 2010
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2ZVL
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![BU of 2zvl by Molmil](/molmil-images/mine/2zvl) | Crystal structure of PCNA in complex with DNA polymerase kappa fragment | 分子名称: | DNA polymerase kappa, Proliferating cell nuclear antigen, SULFATE ION, ... | 著者 | Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. | 登録日 | 2008-11-11 | 公開日 | 2009-02-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
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1WOJ
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![BU of 1woj by Molmil](/molmil-images/mine/1woj) | Crystal structure of human phosphodiesterase | 分子名称: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, PHOSPHATE ION | 著者 | Sakamoto, Y, Tanaka, N, Ichimiya, T, Kurihara, T, Nakamura, K.T. | 登録日 | 2004-08-19 | 公開日 | 2005-03-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of the catalytic fragment of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase J.Mol.Biol., 346, 2005
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2ZVM
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![BU of 2zvm by Molmil](/molmil-images/mine/2zvm) | Crystal structure of PCNA in complex with DNA polymerase iota fragment | 分子名称: | DNA polymerase iota, Proliferating cell nuclear antigen | 著者 | Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. | 登録日 | 2008-11-11 | 公開日 | 2009-02-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
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1V3U
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![BU of 1v3u by Molmil](/molmil-images/mine/1v3u) | Crystal structure of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase in apo form | 分子名称: | CHLORIDE ION, leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase | 著者 | Hori, T, Yokomizo, T, Ago, H, Sugahara, M, Ueno, G, Yamamoto, M, Kumasaka, T, Shimizu, T, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2003-11-05 | 公開日 | 2004-07-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop J.Biol.Chem., 279, 2004
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2ZFU
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![BU of 2zfu by Molmil](/molmil-images/mine/2zfu) | Structure of the methyltransferase-like domain of nucleomethylin | 分子名称: | Cerebral protein 1, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Minami, H, Hashimoto, H, Murayama, A, Yanagisawa, J, Sato, M, Shimizu, T. | 登録日 | 2008-01-14 | 公開日 | 2008-12-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Epigenetic control of rDNA loci in response to intracellular energy status Cell(Cambridge,Mass.), 133, 2008
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2Z5M
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![BU of 2z5m by Molmil](/molmil-images/mine/2z5m) | Complex of Transportin 1 with TAP NLS, crystal form 2 | 分子名称: | Nuclear RNA export factor 1, Transportin-1 | 著者 | Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M. | 登録日 | 2007-07-14 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for substrate recognition and dissociation by human transportin 1 Mol.Cell, 28, 2007
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2Z5J
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![BU of 2z5j by Molmil](/molmil-images/mine/2z5j) | Free Transportin 1 | 分子名称: | Transportin-1 | 著者 | Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M. | 登録日 | 2007-07-13 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis for substrate recognition and dissociation by human transportin 1 Mol.Cell, 28, 2007
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2Z5O
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![BU of 2z5o by Molmil](/molmil-images/mine/2z5o) | Complex of Transportin 1 with JKTBP NLS | 分子名称: | Heterogeneous nuclear ribonucleoprotein D-like, Transportin-1 | 著者 | Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Kose, S, Imamoto, N, Yamada, M, Sato, M. | 登録日 | 2007-07-14 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for substrate recognition and dissociation by human transportin 1 Mol.Cell, 28, 2007
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2ZVK
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![BU of 2zvk by Molmil](/molmil-images/mine/2zvk) | Crystal structure of PCNA in complex with DNA polymerase eta fragment | 分子名称: | DNA polymerase eta, Proliferating cell nuclear antigen | 著者 | Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. | 登録日 | 2008-11-11 | 公開日 | 2009-02-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
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3AUP
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![BU of 3aup by Molmil](/molmil-images/mine/3aup) | Crystal structure of Basic 7S globulin from soybean | 分子名称: | Basic 7S globulin | 著者 | Yoshizawa, T, Shimizu, T, Taichi, M, Nishiuchi, Y, Yamabe, M, Shichijo, N, Unzai, S, Hirano, H, Sato, M, Hashimoto, H. | 登録日 | 2011-02-14 | 公開日 | 2011-04-27 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Crystal structure of basic 7S globulin, a xyloglucan-specific endo-beta-1,4-glucanase inhibitor protein-like protein from soybean lacking inhibitory activity against endo-beta-glucanase Febs J., 278, 2011
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6KYA
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![BU of 6kya by Molmil](/molmil-images/mine/6kya) | Crystal structure of human TLR8 in complex TH1027 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ... | 著者 | Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T. | 登録日 | 2019-09-17 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J.Med.Chem., 63, 2020
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2Z5K
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![BU of 2z5k by Molmil](/molmil-images/mine/2z5k) | Complex of Transportin 1 with TAP NLS | 分子名称: | Nuclear RNA export factor 1, PHOSPHATE ION, Transportin-1 | 著者 | Imasaki, T, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Kose, S, Imamoto, N, Sato, M. | 登録日 | 2007-07-14 | 公開日 | 2007-10-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for substrate recognition and dissociation by human transportin 1 Mol.Cell, 28, 2007
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1WTE
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![BU of 1wte by Molmil](/molmil-images/mine/1wte) | Crystal structure of type II restrcition endonuclease, EcoO109I complexed with cognate DNA | 分子名称: | 5'-D(*AP*CP*CP*GP*GP*GP*CP*CP*CP*TP*GP*CP*C)-3', 5'-D(*GP*GP*CP*AP*GP*GP*GP*CP*CP*CP*GP*GP*T)-3', EcoO109IR, ... | 著者 | Hashimoto, H, Shimizu, T, Imasaki, T, Kato, M, Shichijo, N, Kita, K, Sato, M. | 登録日 | 2004-11-22 | 公開日 | 2004-12-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of type II restriction endonuclease EcoO109I and its complex with cognate DNA J.Biol.Chem., 280, 2005
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5GMF
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![BU of 5gmf by Molmil](/molmil-images/mine/5gmf) | Crystal structure of monkey TLR7 in complex with guanosine and polyU | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2016-07-14 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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5GMH
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![BU of 5gmh by Molmil](/molmil-images/mine/5gmh) | Crystal structure of monkey TLR7 in complex with R848 | 分子名称: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2016-07-14 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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5H6M
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![BU of 5h6m by Molmil](/molmil-images/mine/5h6m) | DNA targeting ADP-ribosyltransferase Pierisin-1 | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
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1WTD
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![BU of 1wtd by Molmil](/molmil-images/mine/1wtd) | Crystal structure of type II restrcition endonuclease, EcoO109I DNA-free form | 分子名称: | EcoO109IR, GLYCEROL | 著者 | Hashimoto, H, Shimizu, T, Imasaki, T, Kato, M, Shichijo, N, Kita, K, Sato, M. | 登録日 | 2004-11-22 | 公開日 | 2004-12-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Crystal structures of type II restriction endonuclease EcoO109I and its complex with cognate DNA J.Biol.Chem., 280, 2005
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5GMG
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![BU of 5gmg by Molmil](/molmil-images/mine/5gmg) | Crystal structure of monkey TLR7 in complex with loxoribine and polyU | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2016-07-14 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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