1C1B
| CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186 | 分子名称: | 6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL, HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN) | 著者 | Hopkins, A.L, Ren, J, Tanaka, H, Baba, B, Okamato, M, Stuart, D.I, Stammers, D.K. | 登録日 | 1999-07-21 | 公開日 | 2000-07-21 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J.Med.Chem., 42, 1999
|
|
8FUJ
| HIV-1 wild type protease with GRL-03419A, with N-(2,5-dimethylphenyl)-4-(pyridin-3-yl)pyrimidin-2-amine as P2-P3 group and 3,5-difluorophenylmethyl as the P1 group | 分子名称: | CHLORIDE ION, FORMIC ACID, GLYCEROL, ... | 著者 | Wang, Y.-F, Agniswamy, J, Ghosh, A.K, Weber, I.T. | 登録日 | 2023-01-17 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. Eur.J.Med.Chem., 255, 2023
|
|
5FT8
| Crystal structure of the complex between the cysteine desulfurase CsdA and the sulfur-acceptor CsdE in the persulfurated state at 2.50 Angstroem resolution | 分子名称: | Cysteine desulfurase CsdA, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Fernandez, F.J, Arda, A, Lopez-Estepa, M, Aranda, J, Penya-Soler, E, Garces, F, Round, A, Campos-Oliva, R, Bruix, M, Coll, M, Tunon, I, Jimenez-Barbero, J, Vega, M.C. | 登録日 | 2016-01-11 | 公開日 | 2016-11-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mechanism of Sulfur Transfer Across Protein-Protein Interfaces: The Cysteine Desulfurase Model System Acs Catalysis, 6, 2016
|
|
8A0C
| Capsular polysaccharide synthesis multienzyme in complex with CMP | 分子名称: | Bcs3, CYTIDINE-5'-MONOPHOSPHATE, GLYCEROL, ... | 著者 | Cifuente, J.O, Schulze, J, Bethe, A, Di Domenico, V, Litschko, C, Budde, I, Eidenberger, L, Thiesler, H, Ramon-Roth, I, Berger, M, Claus, H, DAngelo, C, Marina, A, Gerardy-Schahn, R, Schubert, M, Guerin, M.E, Fiebig, T. | 登録日 | 2022-05-27 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule. Nat.Chem.Biol., 19, 2023
|
|
8A0M
| Capsular polysaccharide synthesis multienzyme in complex with capsular polymer fragment | 分子名称: | Bcs3, MAGNESIUM ION, beta-D-ribosyl-(1->1)-D-ribitol-5-phosphate | 著者 | Cifuente, J.O, Schulze, J, Bethe, A, Di Domenico, V, Litschko, C, Budde, I, Eidenberger, L, Thiesler, H, Ramon-Roth, I, Berger, M, Claus, H, DAngelo, C, Marina, A, Gerardy-Schahn, R, Schubert, M, Guerin, M.E, Fiebig, T. | 登録日 | 2022-05-29 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule. Nat.Chem.Biol., 19, 2023
|
|
7U6Q
| TEM-1 beta-lactamase | 分子名称: | Beta-lactamase, SULFATE ION | 著者 | Ji, Z, Boxer, S.G, Mathews, I.I. | 登録日 | 2022-03-04 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases. J.Am.Chem.Soc., 144, 2022
|
|
6XN9
| Solution NMR structure of recifin, a cysteine-rich tyrosyl-DNA Phosphodiesterase I modulatory peptide from the marine sponge Axinella sp. | 分子名称: | Recifin modulatory peptide | 著者 | Schroeder, C.I, Rosengren, K.J, O'Keefe, B.R. | 登録日 | 2020-07-02 | 公開日 | 2021-02-10 | 実験手法 | SOLUTION NMR | 主引用文献 | Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I. J.Am.Chem.Soc., 142, 2020
|
|
7M7W
| Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Monoclonal antibody S2H97 Fab heavy chain, Monoclonal antibody S2H97 Fab light chain, ... | 著者 | Snell, G, Czudnochowski, N, Croll, T.I, Nix, J.C, Corti, D, Cameroni, E, Pinto, D, Beltramello, M. | 登録日 | 2021-03-29 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape. Nature, 597, 2021
|
|
8FUK
| |
7AEG
| SARS-CoV-2 main protease in a covalent complex with SDZ 224015 derivative, compound 5 | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE, N-[(benzyloxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-L-alaninamide | 著者 | Owen, C.D, Redhead, M.A, Lukacik, P, Strain-Damerell, C, Fearon, D, Brewitz, L, Collette, A, Robinson, C, Collins, P, Radoux, C, Navratilova, I, Douangamath, A, von Delft, F, Malla, T.R, Nugen, T, Hull, H, Tumber, A, Schofield, C.J, Hallet, D, Stuart, D.I, Hopkins, A.L, Walsh, M.A. | 登録日 | 2020-09-17 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep, 11, 2021
|
|
8FBP
| Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation | 分子名称: | Glutamine synthetase | 著者 | Phan, I.Q, Staker, B, Shek, R, Moser, T.H, Evans, J.E, van Voorhis, W.C, Myler, P.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2022-11-29 | 公開日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation To Be Published
|
|
6ZUQ
| Crystal structure of the effector Ecp11-1 from Fulvia fulva | 分子名称: | Extracellular protein 11-1, GLYCEROL, ZINC ION | 著者 | Lazar, N, Mesarich, C, Petit-Houdenot, Y, Talbi, N, Li de la Sierra-Gallay, I, Zelie, E, Blondeau, K, Gracy, J, Ollivier, B, van de Wouw, A, Balesdent, M.H, Idnurm, A, van Tilbeurgh, H, Fudal, I. | 登録日 | 2020-07-23 | 公開日 | 2021-08-04 | 最終更新日 | 2022-07-27 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins. Plos Pathog., 18, 2022
|
|
8QND
| Crystal structure of the ribonucleoside hydrolase C from Lactobacillus reuteri | 分子名称: | CALCIUM ION, Inosine-uridine nucleoside N-ribohydrolase | 著者 | Matyuta, I.O, Minyaev, M.E, Shaposhnikov, L.A, Pometun, E.V, Tishkov, V.I, Popov, V.O, Boyko, K.M. | 登録日 | 2023-09-26 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Functional Examination of Novel Ribonucleoside Hydrolase C (RihC) from Limosilactobacillus reuteri LR1. Int J Mol Sci, 25, 2023
|
|
7ABW
| Crystal structure of siderophore reductase FoxB | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DECYL-BETA-D-MALTOPYRANOSIDE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Josts, I, Tidow, H. | 登録日 | 2020-09-09 | 公開日 | 2021-09-01 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | Structural insights into a novel family of integral membrane siderophore reductases. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7AD5
| Crystal structure of the effector AvrLm5-9 from Leptosphaeria maculans | 分子名称: | ACETATE ION, Avirulence protein LmJ1, GLYCEROL, ... | 著者 | Lazar, N, Mesarich, C, Petit-Houdenot, Y, Talbi, N, Li de la Sierra-Gallay, I, Zelie, E, Blondeau, K, Gracy, J, Ollivier, B, van de Wouw, A, Balesdent, M.H, Idnurm, A, van Tilbeurgh, H, Fudal, I. | 登録日 | 2020-09-14 | 公開日 | 2021-10-06 | 最終更新日 | 2022-07-27 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins. Plos Pathog., 18, 2022
|
|
5JSI
| Structure of membrane protein | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Bacteriorhodopsin, EICOSANE, ... | 著者 | Melnikov, I, Polovinkin, V, Kovalev, K, Shevchenko, V, Gushchin, I, Popov, A, Gordeliy, V. | 登録日 | 2016-05-08 | 公開日 | 2017-05-31 | 最終更新日 | 2023-03-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Fast iodide-SAD phasing for high-throughput membrane protein structure determination. Sci Adv, 3, 2017
|
|
8QQI
| |
6Y4Q
| Structure of a stapled peptide bound to MDM2 | 分子名称: | ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER, E3 ubiquitin-protein ligase Mdm2, ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide | 著者 | Pantelejevs, T, Bakanovych, I. | 登録日 | 2020-02-22 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Org.Biomol.Chem., 18, 2020
|
|
6YFM
| Virus-like particle of bacteriophage ESE021 | 分子名称: | ZINC ION, coat protein | 著者 | Rumnieks, J, Kalnins, G, Sisovs, M, Lieknina, I, Tars, K. | 登録日 | 2020-03-26 | 公開日 | 2020-09-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.762 Å) | 主引用文献 | Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes. Sci Adv, 6, 2020
|
|
7NE7
| oligopeptidase B from S. proteomaculans with modified hinge region in complex with N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide | 分子名称: | N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide, Oligopeptidase B, SPERMINE | 著者 | Petrenko, D.E, Nikolaeva, A.Y, Lazarenko, V.A, Dorovatovskiy, P.V, Vlaskina, A.V, Mikhailova, A.G, Rakitina, T.V, Timofeev, V.I. | 登録日 | 2021-02-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Crystal Structure of N alpha-p-tosyl-lysyl Chloromethylketone-Bound Oligopeptidase B from Serratia Proteamaculans Revealed a New Type of Inhibitor Binding Crystals, 11, 2021
|
|
7ATF
| Structure of EstD11 in complex with p-Nitrophenol | 分子名称: | ACETATE ION, EstD11, FORMIC ACID, ... | 著者 | Miguel-Ruano, V, Rivera, I, Hermoso, J.A. | 登録日 | 2020-10-30 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family. Comput Struct Biotechnol J, 19, 2021
|
|
7AV5
| Structure of EstD11 in complex with Fluorescein | 分子名称: | ACETATE ION, EstD11, FLUORESCIN, ... | 著者 | Miguel-Ruano, V, Rivera, I, Hermoso, J.A. | 登録日 | 2020-11-04 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family. Comput Struct Biotechnol J, 19, 2021
|
|
7AT0
| |
7ATQ
| Structure of EstD11 in complex with cyclohexane carboxylic acid | 分子名称: | ACETATE ION, EstD11, FORMIC ACID, ... | 著者 | Miguel-Ruano, V, Rivera, I, Hermoso, J.A. | 登録日 | 2020-10-30 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Biochemical and Structural Characterization of a novel thermophilic esterase EstD11 provide catalytic insights for the HSL family. Comput Struct Biotechnol J, 19, 2021
|
|
7AUY
| |