5AE9
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![BU of 5ae9 by Molmil](/molmil-images/mine/5ae9) | Crystal structure of mouse PI3 kinase delta in complex with GSK2292767 | 分子名称: | N-[5-[4-(5-{[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]METHYL}-1,3-OXAZOL-2-YL)-1H-INDAZOL-6-YL]-2-(METHYLOXY)-3-PYRIDINYL]METHANESULFONAMIDE, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Down, K.D, Amour, A, Baldwin, I.R, Cooper, A.W.J, Deakin, A.M, Felton, L.M, Guntrip, S.B, Hardy, C, Harrison, Z.A, Jones, K.L, Jones, P, Keeling, S.E, Le, J, Livia, S, Lucas, F, Lunniss, C.J, Parr, N.J, Robinson, E, Rowland, P, Smith, S, Thomas, D.A, Vitulli, G, Washio, Y, Hamblin, N. | 登録日 | 2015-08-26 | 公開日 | 2015-09-16 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Gamma for the Treatment of Respiratory Disease. J.Med.Chem., 58, 2015
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2C2P
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![BU of 2c2p by Molmil](/molmil-images/mine/2c2p) | The crystal structure of mismatch specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans | 分子名称: | ACETATE ION, G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE | 著者 | Moe, E, Leiros, I, Smalas, A.O, McSweeney, S. | 登録日 | 2005-09-29 | 公開日 | 2005-10-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The Crystal Structure of Mismatch Specific Uracil-DNA Glycosylase (Mug) from Deinococcus Radiodurans Reveals a Novel Catalytic Residue and Broad Substrate Specificity J.Biol.Chem., 281, 2006
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2IJQ
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![BU of 2ijq by Molmil](/molmil-images/mine/2ijq) | Crystal structure of protein rrnAC1037 from Haloarcula marismortui, Pfam DUF309 | 分子名称: | Hypothetical protein | 著者 | Malashkevich, V.N, Toro, R, Sauder, J.M, Schwinn, K.D, Thompson, D.A, Rutter, M.E, Dickey, M, Groshong, C, Bain, K.T, Adams, J.M, Reyes, C, Rooney, I, Powell, A, Boice, A, Gheyi, T, Ozyurt, S, Atwell, S, Wasserman, S.R, Emtage, S, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2006-09-30 | 公開日 | 2006-10-24 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Crystal structure of the hypothetical Protein from Haloarcula marismortui To be Published
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2BXG
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![BU of 2bxg by Molmil](/molmil-images/mine/2bxg) | Human serum albumin complexed with ibuprofen | 分子名称: | IBUPROFEN, SERUM ALBUMIN | 著者 | Ghuman, J, Zunszain, P.A, Petitpas, I, Bhattacharya, A.A, Curry, S. | 登録日 | 2005-07-26 | 公開日 | 2005-09-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Basis of the Drug-Binding Specificity of Human Serum Albumin. J.Mol.Biol., 353, 2005
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3OF2
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![BU of 3of2 by Molmil](/molmil-images/mine/3of2) | Crystal structure of InhA_T266D:NADH complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Molle, V, Gulten, G, Vilcheze, C, Veyron-Churlet, R, Zanella-Cleon, I, Sacchettini, J.C, Jacobs Jr, W.R, Kremer, L. | 登録日 | 2010-08-13 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Mol.Microbiol., 78, 2010
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1AK6
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![BU of 1ak6 by Molmil](/molmil-images/mine/1ak6) | DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | DESTRIN | 著者 | Hatanaka, H, Moriyama, K, Ogura, K, Ichikawa, S, Yahara, I, Inagaki, F. | 登録日 | 1997-05-29 | 公開日 | 1997-11-12 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Tertiary structure of destrin and structural similarity between two actin-regulating protein families. Cell(Cambridge,Mass.), 85, 1996
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5DD6
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2IYG
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![BU of 2iyg by Molmil](/molmil-images/mine/2iyg) | Dark state structure of the BLUF domain of the rhodobacterial protein AppA | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, APPA, ... | 著者 | Jung, A, Reinstein, J, Domratcheva, T, Shoeman, R.-L, Schlichting, I. | 登録日 | 2006-07-17 | 公開日 | 2006-09-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of the Appa Bluf Domain Photoreceptor Provide Insights Into Blue Light- Mediated Signal Transduction. J.Mol.Biol., 362, 2006
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5DGK
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![BU of 5dgk by Molmil](/molmil-images/mine/5dgk) | SCCmec type IV Cch - active helicase | 分子名称: | Active helicase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Rice, P.A, Mir-Sanchis, I. | 登録日 | 2015-08-27 | 公開日 | 2016-08-24 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.895 Å) | 主引用文献 | Staphylococcal SCCmec elements encode an active MCM-like helicase and thus may be replicative. Nat.Struct.Mol.Biol., 23, 2016
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3OSR
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![BU of 3osr by Molmil](/molmil-images/mine/3osr) | Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. coli maltose binding protein at position 311 | 分子名称: | Maltose-binding periplasmic protein,Green fluorescent protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Echevarria, I.M, Marvin, J.S, Looger, L.L, Schreiter, E.R. | 登録日 | 2010-09-09 | 公開日 | 2011-10-26 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A genetically encoded, high-signal-to-noise maltose sensor. Proteins, 79, 2011
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2JJW
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![BU of 2jjw by Molmil](/molmil-images/mine/2jjw) | Structure of human signal regulatory protein (sirp) gamma | 分子名称: | SIGNAL REGULATORY PROTEIN GAMMA | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | 登録日 | 2008-04-22 | 公開日 | 2008-08-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47. Mol.Cell, 31, 2008
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2E0A
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![BU of 2e0a by Molmil](/molmil-images/mine/2e0a) | Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with AMPPNP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pyruvate dehydrogenase kinase isozyme 4 | 著者 | Kukimoto-Niino, M, Tokmakov, A, Terada, T, Shiromizu, I, Kawamoto, M, Matsusue, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2006-10-03 | 公開日 | 2007-10-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr.,Sect.D, 67, 2011
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5DD3
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2E8G
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2JLF
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![BU of 2jlf by Molmil](/molmil-images/mine/2jlf) | STRUCTURAL EXPLANATION FOR THE ROLE OF MN IN THE ACTIVITY OF PHI6 RNA- DEPENDENT RNA POLYMERASE | 分子名称: | MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE | 著者 | Poranen, M.M, Salgado, P.S, Koivunen, M.R.L, Wright, S, Bamford, D.H, Stuart, D.I, Grimes, J.M. | 登録日 | 2008-09-08 | 公開日 | 2008-11-04 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural Explanation for the Role of Mn2+ in the Activity of {Phi}6 RNA-Dependent RNA Polymerase. Nucleic Acids Res., 36, 2008
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5AJV
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![BU of 5ajv by Molmil](/molmil-images/mine/5ajv) | Human PFKFB3 in complex with an indole inhibitor 1 | 分子名称: | (2S)-2-amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxy-propanamide, 2,6-di-O-phosphono-beta-D-fructofuranose, HUMAN PFKFB3, ... | 著者 | Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J. | 登録日 | 2015-02-27 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3. J.Med.Chem., 58, 2015
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2EC8
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![BU of 2ec8 by Molmil](/molmil-images/mine/2ec8) | Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor | 著者 | Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J. | 登録日 | 2007-02-11 | 公開日 | 2007-08-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor Cell(Cambridge,Mass.), 130, 2007
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9CRN
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5AJ2
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![BU of 5aj2 by Molmil](/molmil-images/mine/5aj2) | Cryo electron tomography of the Naip5-Nlrc4 inflammasome | 分子名称: | NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4 | 著者 | Diebolder, C.A, Halff, E.F, Koster, A.J, Huizinga, E.G, Koning, R.I. | 登録日 | 2015-02-20 | 公開日 | 2015-11-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (40 Å) | 主引用文献 | Cryoelectron Tomography of the Naip5/Nlrc4 Inflammasome: Implications for Nlr Activation. Structure, 23, 2015
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5AJY
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![BU of 5ajy by Molmil](/molmil-images/mine/5ajy) | Human PFKFB3 in complex with an indole inhibitor 4 | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, N-(4-{[3-(1-methyl-1H-pyrazol-4-yl)-1H-indol-5-yl]oxy}phenyl)glycinamide, ... | 著者 | Boyd, S, Brookfield, J.L, Critchlow, S.E, Cumming, I.A, Curtis, N.J, Debreczeni, J.E, Degorce, S.L, Donald, C, Evans, N.J, Groombridge, S, Hopcroft, P, Jones, N.P, Kettle, J.G, Lamont, S, Lewis, H.J, MacFaull, P, McLoughlin, S.B, Rigoreau, L.J.M, Smith, J.M, St-Gallay, S, Stock, J.K, Wheatley, E.R, Winter, J, Wingfield, J. | 登録日 | 2015-02-27 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase Pfkfb3. J.Med.Chem., 58, 2015
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3OTS
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![BU of 3ots by Molmil](/molmil-images/mine/3ots) | MDR769 HIV-1 protease complexed with MA/CA hepta-peptide | 分子名称: | MA/CA substrate peptide, Multi-drug resistant HIV-1 protease | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | 登録日 | 2010-09-13 | 公開日 | 2011-03-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease. Protein J., 30, 2011
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3OTY
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![BU of 3oty by Molmil](/molmil-images/mine/3oty) | MDR769 HIV-1 protease complexed with RT/RH hepta-peptide | 分子名称: | MDR HIV-1 protease, RT/RH substrate peptide | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | 登録日 | 2010-09-14 | 公開日 | 2011-03-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease. Protein J., 30, 2011
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3OUA
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![BU of 3oua by Molmil](/molmil-images/mine/3oua) | MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide | 分子名称: | HIV-1 protease, p1/p6 substrate peptide | 著者 | Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. | 登録日 | 2010-09-14 | 公開日 | 2011-03-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease. Protein J., 30, 2011
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521P
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![BU of 521p by Molmil](/molmil-images/mine/521p) | THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, H-RAS P21 PROTEIN, MAGNESIUM ION | 著者 | Schlichting, I, Krengel, U, Kabsch, W, Wittinghofer, A, Pai, E.F. | 登録日 | 1991-06-06 | 公開日 | 1994-01-31 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
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5A0P
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![BU of 5a0p by Molmil](/molmil-images/mine/5a0p) | Apo-structure of metalloprotease Zmp1 from Clostridium difficile | 分子名称: | ZINC ION, ZINC METALLOPROTEASE ZMP1 | 著者 | Schacherl, M, Pichlo, C, Neundorf, I, Baumann, U. | 登録日 | 2015-04-22 | 公開日 | 2015-08-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | 主引用文献 | Structural Basis of Proline-Proline Peptide Bond Specificity of the Metalloprotease Zmp1 Implicated in Motility of Clostridium Difficile. Structure, 23, 2015
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