1AK6
DESTRIN, NMR, MINIMIZED AVERAGE STRUCTURE
Summary for 1AK6
| Entry DOI | 10.2210/pdb1ak6/pdb |
| Descriptor | DESTRIN (1 entity in total) |
| Functional Keywords | actin depolymerization factor, actin-binding protein |
| Biological source | Homo sapiens, Sus scrofa (human, pig) |
| Total number of polymer chains | 1 |
| Total formula weight | 19379.65 |
| Authors | Hatanaka, H.,Moriyama, K.,Ogura, K.,Ichikawa, S.,Yahara, I.,Inagaki, F. (deposition date: 1997-05-29, release date: 1997-11-12, Last modification date: 2024-05-22) |
| Primary citation | Hatanaka, H.,Ogura, K.,Moriyama, K.,Ichikawa, S.,Yahara, I.,Inagaki, F. Tertiary structure of destrin and structural similarity between two actin-regulating protein families. Cell(Cambridge,Mass.), 85:1047-1055, 1996 Cited by PubMed Abstract: Destrin is an isoprotein of cofilin that regulates actin cytoskeleton in various eukaryotes. We determined the tertiary structure of destrin by triple-resonance multidimensional nuclear magnetic resonance. In spite of there being no significant amino acid sequence homology, we found that the folding of destrin was strikingly similar to that of repeated segments in the gelsolin family, which resulted in a new protein fold group. Sequential dissimilarity of the actin-binding helix of destrin to that of gelsolin explains the Ca2+-independent actin-binding of destrin. Possible mechanisms of phosphorylation-sensitive phosphoinositide-competitive actin binding, of pH-dependent filament severing, and of nuclear translocation with actin in response to stresses, are discussed on the basis of the tertiary structure. PubMed: 8674111DOI: 10.1016/S0092-8674(00)81305-7 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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