2E0A

Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with AMPPNP

Summary for 2E0A

Entry DOI	10.2210/pdb2e0a/pdb
Descriptor	Pyruvate dehydrogenase kinase isozyme 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	pdk4, kinase, atp-binding, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, transferase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix: Q16654
Total number of polymer chains	2
Total formula weight	90602.99
Authors	Kukimoto-Niino, M.,Tokmakov, A.,Terada, T.,Shiromizu, I.,Kawamoto, M.,Matsusue, T.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-10-03, release date: 2007-10-09, Last modification date: 2023-10-25)
Primary citation	Kukimoto-Niino, M.,Tokmakov, A.,Terada, T.,Ohbayashi, N.,Fujimoto, T.,Gomi, S.,Shiromizu, I.,Kawamoto, M.,Matsusue, T.,Shirouzu, M.,Yokoyama, S. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr.,Sect.D, 67:763-773, 2011 Cited by PubMed: 21904029 DOI: 10.1107/S090744491102405X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation