7SWN
 
 | | G32A4 Fab in complex with SARS-CoV-2 Spike 6P (RBD local reconstruction) | | 分子名称: | G32A4 Fab heavy chain, G32A4 Fab light chain, Spike protein S1 | | 著者 | Windsor, I.W, Tong, P, Wesemann, D.R, Harrison, S.C. | | 登録日 | 2021-11-20 | | 公開日 | 2022-04-27 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1.
Sci Immunol, 7, 2022
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5L1B
 | | AMPA subtype ionotropic glutamate receptor GluA2 in Apo state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Glutamate receptor 2 | | 著者 | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | | 登録日 | 2016-07-28 | | 公開日 | 2016-10-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Neuron, 91, 2016
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5L2Q
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9FJW
 | | Solution NMR structure of a peptide encompassing residues 2-36 of the human formin INF2 | | 分子名称: | Inverted formin-2 | | 著者 | Jimenez, M.A, Comas, L, Labat-de-Hoz, L, Correas, I, Alonso, M.A. | | 登録日 | 2024-05-31 | | 公開日 | 2024-09-11 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and function of the N-terminal extension of the formin INF2.
Cell Mol Life Sci, 79, 2022
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8QY7
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9F1J
 | | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14 | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[2-[2-[2-[2-[2-[2-[2,6-bis(oxidanylidene)piperidin-3-yl]-1,3-bis(oxidanylidene)isoindol-4-yl]oxyethanoylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-[4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]ethyl]phenoxy]butanamide | | 著者 | Balourdas, D.I, Edmonds, A.K, Marsh, G.P, Maple, H.J, Spencer, J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | | 登録日 | 2024-04-19 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.13003039 Å) | | 主引用文献 | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14
to be published
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9F1L
 | | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 35 | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[2-[2-[(3R)-2,6-bis(oxidanylidene)piperidin-3-yl]-1,3-bis(oxidanylidene)isoindol-4-yl]oxyethyl]-2-[4-[2-[2-[2-[4-[3-(dimethylamino)propoxy]phenyl]ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethyl]piperazin-1-yl]ethanamide | | 著者 | Balourdas, D.I, Edmonds, A.K, Marsh, G.P, Maple, H.J, Spencer, J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | | 登録日 | 2024-04-19 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.30000627 Å) | | 主引用文献 | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 35
to be published
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5L76
 | | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form) | | 分子名称: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde synthase, mitochondrial, ... | | 著者 | Kopec, J, Pena, I.A, Rembeza, E, Strain-Damerell, C, Chalk, R, Borkowska, O, Goubin, S, Velupillai, S, Burgess-Brown, N, Arrowsmith, C, Edwards, A, Bountra, C, Arruda, P, Yue, W.W. | | 登録日 | 2016-06-02 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)
To Be Published
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1D0I
 | | CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINASE FROM STREPTOMYCES COELICOLOR COMPLEXED WITH PHOSPHATE IONS | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, TYPE II 3-DEHYDROQUINATE HYDRATASE | | 著者 | Roszak, A.W, Krell, T, Hunter, I.S, Coggins, J.R, Lapthorn, A.J. | | 登録日 | 1999-09-10 | | 公開日 | 2000-09-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor.
Structure, 10, 2002
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9GG0
 | | P301L tau filaments from human brain | | 分子名称: | Isoform Tau-D of Microtubule-associated protein tau | | 著者 | Schweighauser, M, Shi, Y, Murzin, A.G, Garringer, H.J, Vidal, R, Murrell, J.R, Erro, M.E, Seelaar, H, Ferrer, I, van Swieten, J.C, Ghetti, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2024-08-12 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | | 主引用文献 | Novel tau filament folds in individuals with MAPT mutations P301L and P301T.
Biorxiv, 2024
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9GG6
 | | P301T type II tau filaments from human brain | | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau | | 著者 | Schweighauser, M, Shi, Y, Murzin, A.G, Garringer, H.J, Vidal, R, Murrell, J.R, Erro, M.E, Seelaar, H, Ferrer, I, van Swieten, J.C, Ghetti, B, Scheres, S.H.W, Goedert, M. | | 登録日 | 2024-08-13 | | 公開日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Novel tau filament folds in individuals with MAPT mutations P301L and P301T.
Biorxiv, 2024
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9F56
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8SBI
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9GSO
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7T8Y
 | | Structure of Class A sortase from Streptococcus pyogenes bound to lipid II mimetic, LPATA: Thr-in conformation | | 分子名称: | ACE-ALA-ZGL-LYS-DAL-DAL, BE2-LEU-PRO-ALA-THR-ALA-ALA, Sortase | | 著者 | Piper, I.M, Antos, J.M, Amacher, J.F. | | 登録日 | 2021-12-17 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition.
J.Biol.Chem., 298, 2022
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9F5B
 | | Identification of zinc ions in LMO4. | | 分子名称: | LIM domain transcription factor LMO4,LIM domain-binding protein 1, ZINC ION | | 著者 | El Omari, K, Forsyth, I, Mancini, E.J, Wagner, A. | | 登録日 | 2024-04-28 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Utilizing anomalous signals for element identification in macromolecular crystallography.
Acta Crystallogr D Struct Biol, 80, 2024
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7OPR
 | | Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123 | | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E. | | 登録日 | 2021-06-01 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
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7SOY
 | | The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex | | 分子名称: | Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | 著者 | Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y. | | 登録日 | 2021-11-01 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
Elife, 11, 2022
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7T8Z
 | | Structure of Class A sortase from Streptococcus pyogenes bound to lipid II mimetic, LPATA: Thr-out conformation | | 分子名称: | ACE-ALA-ZGL-LYS-DAL-DAL, BE2-LEU-PRO-ALA-THR-ALA-ALA, Sortase | | 著者 | Piper, I.M, Antos, J.M, Amacher, J.F. | | 登録日 | 2021-12-17 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition.
J.Biol.Chem., 298, 2022
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9F1K
 | | First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30 | | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[2-[2-[2-[4-[3-(dimethylamino)propoxy]phenyl]ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethyl]piperazin-1-yl]-N-(2-methoxyethyl)ethanamide, Bromodomain-containing protein 4 | | 著者 | Balourdas, D.I, Edmonds, A.K, Marsh, G.P, Maple, H.J, Spencer, J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | | 登録日 | 2024-04-19 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30
to be published
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9FJN
 | | Solution NMR structure of a peptide encompassing residues 2-19 of the human formin INF2 | | 分子名称: | Inverted formin-2 | | 著者 | Jimenez, M.A, Comas, L, Labat-de-Hoz, L, Correas, I, Alonso, M.A. | | 登録日 | 2024-05-31 | | 公開日 | 2024-09-11 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and function of the N-terminal extension of the formin INF2.
Cell Mol Life Sci, 79, 2022
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9FMT
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9FO7
 | | Cryo-EM structure of the BcsE2F2 regulatory subcomplex from the E. coli Bcs macrocomplex for cellulose secretion (local refinement) | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Cellulose biosynthesis protein BcsF, Cyclic di-GMP binding protein BcsE | | 著者 | Anso, I, Krasteva, P.V. | | 登録日 | 2024-06-11 | | 公開日 | 2024-10-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural basis for synthase activation and cellulose modification in the E. coli Type II Bcs secretion system.
Nat Commun, 15, 2024
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9GCV
 | | Identification of chloride ions in lysozyme at long wavelengths | | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION | | 著者 | El Omari, K, Forsyth, I, Orr, C.M, Wagner, A. | | 登録日 | 2024-08-02 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.703 Å) | | 主引用文献 | Utilizing anomalous signals for element identification in macromolecular crystallography.
Acta Crystallogr D Struct Biol, 80, 2024
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8SO1
 | | Human CYP3A4 bound to three caffeine molecules | | 分子名称: | CAFFEINE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sevrioukova, I.F. | | 登録日 | 2023-04-28 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding.
J.Biol.Chem., 299, 2023
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