9F1K

First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30

This is a non-PDB format compatible entry.

Summary for 9F1K

• Entry DOI: 10.2210/pdb9f1k/pdb
• Descriptor: Bromodomain-containing protein 4, 2-[4-[2-[2-[2-[4-[3-(dimethylamino)propoxy]phenyl]ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethyl]piperazin-1-yl]-N-(2-methoxyethyl)ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, epigenetic drugs, inhibitor, protacs, gene regulation
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15807.28

Authors

Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2024-04-19, release date: 2024-09-11)

• Primary citation: Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC); First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30; to be published,

Experimental method

X-RAY DIFFRACTION (1.61 Å)