9F1K
First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30
This is a non-PDB format compatible entry.
Summary for 9F1K
Entry DOI | 10.2210/pdb9f1k/pdb |
Descriptor | Bromodomain-containing protein 4, 2-[4-[2-[2-[2-[4-[3-(dimethylamino)propoxy]phenyl]ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethyl]piperazin-1-yl]-N-(2-methoxyethyl)ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, epigenetic drugs, inhibitor, protacs, gene regulation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15807.28 |
Authors | Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2024-04-19, release date: 2024-09-11) |
Primary citation | Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) First bromodomain of BRD4 in complex with ISOX-DUAL based inhibitor 30 to be published, |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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