9GG0

P301L tau filaments from human brain

Summary for 9GG0

Entry DOI	10.2210/pdb9gg0/pdb
EMDB information	51319
Descriptor	Isoform Tau-D of Microtubule-associated protein tau (1 entity in total)
Functional Keywords	p301l tau, frontotemporal dementia and parkinsonism linked to chromosome 17, electron cryo-microscopy, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	34086.28
Authors	Schweighauser, M.,Shi, Y.,Murzin, A.G.,Garringer, H.J.,Vidal, R.,Murrell, J.R.,Erro, M.E.,Seelaar, H.,Ferrer, I.,van Swieten, J.C.,Ghetti, B.,Scheres, S.H.W.,Goedert, M. (deposition date: 2024-08-12, release date: 2024-09-11)
Primary citation	Schweighauser, M.,Shi, Y.,Murzin, A.G.,Garringer, H.J.,Vidal, R.,Murrell, J.R.,Erro, M.E.,Seelaar, H.,Ferrer, I.,van Swieten, J.C.,Ghetti, B.,Scheres, S.H.W.,Goedert, M. Novel tau filament folds in individuals with MAPT mutations P301L and P301T. Biorxiv, 2024 Cited by PubMed: 39185206 DOI: 10.1101/2024.08.15.608062 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.81 Å)

Structure validation