9F1J
First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14
This is a non-PDB format compatible entry.
Summary for 9F1J
Entry DOI | 10.2210/pdb9f1j/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-[2-[2-[2-[2-[2-[2-[2,6-bis(oxidanylidene)piperidin-3-yl]-1,3-bis(oxidanylidene)isoindol-4-yl]oxyethanoylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-[4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]ethyl]phenoxy]butanamide, ... (4 entities in total) |
Functional Keywords | bromodomain, epigenetic drugs, inhibitor, protacs, thalidomide, gene regulation |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 16157.56 |
Authors | Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2024-04-19, release date: 2024-09-11) |
Primary citation | Balourdas, D.I.,Edmonds, A.K.,Marsh, G.P.,Maple, H.J.,Spencer, J.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14 to be published, |
Experimental method | X-RAY DIFFRACTION (1.13003035503 Å) |
Structure validation
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