8SBI

Crystal structure of human sterol 14 alpha-demethylase (CYP51) in the ligand-free state

Summary for 8SBI

Entry DOI	10.2210/pdb8sbi/pdb
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
Functional Keywords	monooxygenase, cytochrome p450, endoplasmic reticulum, sterol biosynthesis, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	104587.68
Authors	Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2023-04-03, release date: 2023-04-12, Last modification date: 2025-06-25)
Primary citation	Hargrove, T.Y.,Lamb, D.C.,Wawrzak, Z.,Minasov, G.,Goldstone, J.V.,Kelly, S.L.,Stegeman, J.J.,Lepesheva, G.I. Unique Structural Features Relate to Evolutionary Adaptation of Cytochrome P450 in the Abyssal Zone Int J Mol Sci, 26:-, 2025 Cited by DOI: 10.3390/ijms26125689 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.73 Å)

Structure validation