8SBI
Crystal structure of human sterol 14 alpha-demethylase (CYP51) in the ligand-free state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lanosterol 14-alpha demethylase | polymer | 453 | 51677.4 | 2 | UniProt (Q16850) Pfam (PF00067) | Homo sapiens (human) | LDM,CYPLI,Cytochrome P450 51A1,Cytochrome P450-14DM,Cytochrome P45014DM,Cytochrome P450LI,Sterol 14-alpha demethylase |
| 2 | C, D (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A, B: 61 - 502 (UniProt: Q16850)
| PDB | External Database | Details |
|---|---|---|
| Met 50 | - | initiating methionine |
| Ala 51 | - | expression tag |
| Lys 52 | - | expression tag |
| Lys 53 | - | expression tag |
| Thr 54 | - | expression tag |
| Ser 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Lys 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Lys 59 | - | expression tag |
| Leu 60 | - | expression tag |
| Ala 231 | Asp 237 | engineered mutation |
| Ala 314 | His 320 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103354.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1233.0 | |
| All* | Total formula weight | 104587.7 |
