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PDB: 74 件
3K48
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BU of 3k48 by Molmil
Crystal structure of APRIL bound to a peptide
分子名称: Tumor necrosis factor ligand superfamily member 13, peptide
著者Hymowitz, S.G.
登録日2009-10-05
公開日2009-11-24
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.
J.Mol.Biol., 396, 2010
1JPY
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BU of 1jpy by Molmil
Crystal structure of IL-17F
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Hymowitz, S.G, Filvaroff, E.H, Yin, J, Lee, J, Cai, L, Risser, P, Maruoka, M, Mao, W, Foster, J, Kelley, R, Pan, G, Gurney, A.L, de Vos, A.M, Starovasnik, M.A.
登録日2001-08-03
公開日2001-09-28
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
EMBO J., 20, 2001
1RJ7
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BU of 1rj7 by Molmil
Crystal structure of EDA-A1
分子名称: Ectodysplasin A
著者Hymowitz, S.G, Compaan, D.M, Yan, M, Ackerly, H, Dixit, V.M, Starovasnik, M.A, de Vos, A.M.
登録日2003-11-18
公開日2003-12-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.
Structure, 11, 2003
1RJ8
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BU of 1rj8 by Molmil
The crystal structure of TNF family member EDA-A2
分子名称: ectodysplasin-A isoform EDA-A2
著者Hymowitz, S.G, Compaan, D.M, Yan, M, Ackerly, H, Dixit, V.M, Starovasnik, M.A, de Vos, A.M.
登録日2003-11-18
公開日2003-12-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献The Crystal Structure of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity
STRUCTURE, 11, 2003
2HEV
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BU of 2hev by Molmil
Crystal structure of the complex between OX40L and OX40
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 4, Tumor necrosis factor receptor superfamily member 4
著者Hymowitz, S.G, Compaan, D.M.
登録日2006-06-22
公開日2006-08-29
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献The Crystal Structure of the Costimulatory OX40-OX40L Complex.
Structure, 14, 2006
2HEW
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BU of 2hew by Molmil
The X-ray crystal structure of murine OX40L
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor ligand superfamily member 4
著者Hymowitz, S.G, Compaan, D.M.
登録日2006-06-22
公開日2006-08-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The Crystal Structure of the Costimulatory OX40-OX40L Complex.
Structure, 14, 2006
2HFG
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BU of 2hfg by Molmil
Crystal structure of hBR3 bound to CB3s-Fab
分子名称: CB3s Fab heavy chain, CB3s Fab light chain (kappa), Tumor necrosis factor receptor superfamily member 13C
著者Hymowitz, S.G.
登録日2006-06-23
公開日2006-11-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
1D0G
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BU of 1d0g by Molmil
CRYSTAL STRUCTURE OF DEATH RECEPTOR 5 (DR5) BOUND TO APO2L/TRAIL
分子名称: APOPTOSIS-2 LIGAND, CHLORIDE ION, DEATH RECEPTOR-5, ...
著者Hymowitz, S.G, Christinger, H.W, Fuh, G, O'Connell, M.P, Kelley, R.F, Ashkenazi, A, de Vos, A.M.
登録日1999-09-09
公開日1999-10-22
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
Mol.Cell, 4, 1999
2H9G
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Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5)
分子名称: Fab BdF1, heavy chain, light chain, ...
著者Hymowitz, S.G, Compaan, D.M.
登録日2006-06-09
公開日2006-08-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists.
J.Mol.Biol., 361, 2006
2HFF
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BU of 2hff by Molmil
Crystal structure of CB2 Fab
分子名称: CB2 Fab, heavy chain, light chain
著者Hymowitz, S.G.
登録日2006-06-23
公開日2006-11-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood, 108, 2006
2HEY
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BU of 2hey by Molmil
Crystal structure of murine OX40L bound to human OX40
分子名称: SULFATE ION, Tumor necrosis factor ligand superfamily member 4, Tumor necrosis factor receptor superfamily member 4
著者Hymowitz, S.G.
登録日2006-06-22
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Crystal Structure of the Costimulatory OX40-OX40L Complex.
Structure, 14, 2006
1DG6
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BU of 1dg6 by Molmil
CRYSTAL STRUCTURE OF APO2L/TRAIL
分子名称: APO2L/TNF-RELATED APOPOTIS INDUCING LIGAND (TRAIL), CHLORIDE ION, ZINC ION
著者Hymowitz, S.G, O'ConnelL, M.P, Ultsch, M.H, de Vos, A.M, Kelley, R.F.
登録日1999-11-23
公開日2000-01-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Biochemistry, 39, 2000
3DVN
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BU of 3dvn by Molmil
Crystal structure of K63-specific fab Apu2.16 bound to K63-linked di-ubiquitin
分子名称: Human IgG1 fab fragment heavy chain, Human IgG1 fab fragment light chain, Ubiquitin, ...
著者Hymowitz, S.G.
登録日2008-07-18
公開日2008-09-30
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell(Cambridge,Mass.), 134, 2008
3DVG
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BU of 3dvg by Molmil
Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin
分子名称: Human IgG1 fab fragment heavy chain, Human IgG1 fab fragment light chain, Ubiquitin, ...
著者Hymowitz, S.G.
登録日2008-07-18
公開日2008-09-30
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell(Cambridge,Mass.), 134, 2008
2RAX
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BU of 2rax by Molmil
Crystal structure of Borealin (20-78) bound to Survivin (1-120)
分子名称: Baculoviral IAP repeat-containing protein 5, Borealin, ZINC ION
著者Hymowitz, S.G.
登録日2007-09-17
公開日2007-10-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.
J.Biol.Chem., 282, 2007
2RAW
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BU of 2raw by Molmil
Crystal structure of the Borealin-Survivin complex
分子名称: Baculoviral IAP repeat-containing protein 5, Borealin, ZINC ION
著者Hymowitz, S.G.
登録日2007-09-17
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.
J.Biol.Chem., 282, 2007
3HO5
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BU of 3ho5 by Molmil
Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
分子名称: CALCIUM ION, Hedgehog-interacting protein, Sonic hedgehog protein, ...
著者Hymowitz, S.G, Bosanac, I.
登録日2009-06-01
公開日2009-06-23
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
3HO4
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BU of 3ho4 by Molmil
Crystal structure of Hedgehog-interacting protein (HHIP)
分子名称: Hedgehog-interacting protein
著者Hymowitz, S.G, Bosanac, I.
登録日2009-06-01
公開日2009-06-23
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nat.Struct.Mol.Biol., 16, 2009
3HL5
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BU of 3hl5 by Molmil
Crystal structure of XIAP BIR3 with CS3
分子名称: (3S)-1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-3-methyl-N-(2-pyrimidin-2-ylphenyl)-L-prolinamide, Baculoviral IAP repeat-containing protein 4, ZINC ION
著者Hymowitz, S.G.
登録日2009-05-26
公開日2009-06-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.
Acs Chem.Biol., 4, 2009
3L95
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BU of 3l95 by Molmil
Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ...
著者Hymowitz, S.G, de Leon, G.P.
登録日2010-01-04
公開日2010-03-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Therapeutic antibody targeting of individual Notch receptors.
Nature, 464, 2010
3MXV
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BU of 3mxv by Molmil
Crystal structure of fab fragment of anti-Shh 5E1 chimera
分子名称: SULFATE ION, fab fragment of anti-Shh 5E1 mouse/human chimera, heavy chain, ...
著者Hymowitz, S.G, Maun, H.R.
登録日2010-05-07
公開日2010-05-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
J.Biol.Chem., 285, 2010
3MXW
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BU of 3mxw by Molmil
Crystal structure Sonic hedgehog bound to the 5E1 fab fragment
分子名称: 5E1 heavy chain, 5E1 light chain, CALCIUM ION, ...
著者Hymowitz, S.G, Maun, H.R.
登録日2010-05-07
公開日2010-05-26
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
J.Biol.Chem., 285, 2010
4G3E
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BU of 4g3e by Molmil
Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)
分子名称: (2R)-4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol, NF-kappa-beta-inducing kinase, SULFATE ION
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
4G3F
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Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)
分子名称: 3-{2-[(5-fluoro-2-hydroxyphenyl)amino]-1,3-thiazol-4-yl}benzonitrile, NF-kappa-beta-inducing kinase
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.642 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012
4G3D
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Crystal structure of human NF-kappaB inducing kinase (NIK)
分子名称: MAGNESIUM ION, NF-kappa-beta-inducing kinase
著者Hymowitz, S.G, de Leon-Boenig, G.
登録日2012-07-13
公開日2012-08-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.
Structure, 20, 2012

 

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