Crystal structure of Borealin (20-78) bound to Survivin (1-120)

Summary for 2RAX

DescriptorBaculoviral IAP repeat-containing protein 5, Borealin, ZINC ION (3 entities in total)
Functional Keywordscell cycle, dasrab, chromosomal passender complex, iap, bir, apoptosis, cell division, centromere, chromosomal protein, metal-binding, mitosis, nucleus, phosphorylation, protease inhibitor, thiol protease inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm O15392
Nucleus, nucleolus Q53HL2
Total number of polymer chains6
Total molecular weight67343.78
Hymowitz, S.G. (deposition date: 2007-09-17, release date: 2007-10-30, Last modification date: 2011-07-13)
Primary citation
Bourhis, E.,Hymowitz, S.G.,Cochran, A.G.
The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.
J.Biol.Chem., 282:35018-35023, 2007
PubMed: 17881355 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M706233200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2709 1.4% 8.2% 1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02