7N8R
 
 | | FGTGFG segment from the Nucleoporin p54, residues 63-68 | | Descriptor: | FGTGFG segment from the Nucleoporin p54, residues 63-68, trifluoroacetic acid | | Authors: | Hughes, M.P, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2021-06-15 | | Release date: | 2022-02-16 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Extended beta-Strands Contribute to Reversible Amyloid Formation.
Acs Nano, 16, 2022
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8V1L
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8TH5
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8TH1
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8TH6
 | | Crystal Structure of the G3BP1 NTF2-like domain bound to USP10 peptide | | Descriptor: | 1,2-ETHANEDIOL, Ras GTPase-activating protein-binding protein 1, Ubiquitin carboxyl-terminal hydrolase 10 | | Authors: | Hughes, M.P, Taylor, J.P, Yang, Z. | | Deposit date: | 2023-07-14 | | Release date: | 2024-03-20 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.34 Å) | | Cite: | Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
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6BZP
 | | STGGYG from low-complexity domain of FUS, residues 77-82 | | Descriptor: | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, RNA-binding protein FUS | | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | | Deposit date: | 2017-12-25 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6BZM
 | | GFGNFGTS from low-complexity/FG repeat domain of Nup98, residues 116-123 | | Descriptor: | Nuclear pore complex protein Nup98-Nup96 | | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Chong, L, Gonen, T, Eisenberg, D.S. | | Deposit date: | 2017-12-24 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON CRYSTALLOGRAPHY (0.9 Å) | | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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1LO2
 | | Retro-Diels-Alderase Catalytic Antibody | | Descriptor: | If kappa light chain, Ig gamma 2a heavy chain, [2'-CARBOXYLETHYL]-10-METHYL-ANTHRACENE ENDOPEROXIDE | | Authors: | Hugot, M, Reymond, J.L, Baumann, U. | | Deposit date: | 2002-05-06 | | Release date: | 2002-06-26 | | Last modified: | 2021-07-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1LO4
 | | Retro-Diels-Alderase Catalytic antibody 9D9 | | Descriptor: | If kappa light chain, Ig gamma 2a heavy chain | | Authors: | Hugot, M, Reymond, J.L, Baumann, U. | | Deposit date: | 2002-05-06 | | Release date: | 2002-07-03 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1LO0
 | | Catalytic Retro-Diels-Alderase Transition State Analogue Complex | | Descriptor: | 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID, If kappa light chain, Ig gamma 2a heavy chain | | Authors: | Hugot, M, Reymond, J.L, Baumann, U. | | Deposit date: | 2002-05-05 | | Release date: | 2002-06-26 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue.
Proc.Natl.Acad.Sci.USA, 99, 2002
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6BWZ
 | | SYSGYS from low-complexity domain of FUS, residues 37-42 | | Descriptor: | SYSGYS peptide from low-complexity domain of FUS | | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Tamir, G, Eisenberg, D.S. | | Deposit date: | 2017-12-15 | | Release date: | 2018-04-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6BXV
 | | SYSSYGQS from low-complexity domain of FUS, residues 54-61 | | Descriptor: | FUS | | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | | Deposit date: | 2017-12-19 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6BXX
 | | GYNGFG from low-complexity domain of hnRNPA1, residues 243-248 | | Descriptor: | hnRNPA1 | | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | | Deposit date: | 2017-12-19 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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1LO3
 | | Retro-Diels-Alderase Catalytic Antibody: Product Analogue | | Descriptor: | 3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID, If kappa light chain, Ig gamma 2a heavy chain | | Authors: | Hugot, M, Reymond, J.L, Baumann, U. | | Deposit date: | 2002-05-06 | | Release date: | 2002-07-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue.
Proc.Natl.Acad.Sci.USA, 99, 2002
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8TH7
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6T13
 | | CRYSTAL STRUCTURE OF GLUCOCEREBROSIDASE IN COMPLEX WITH A PYRROLOPYRAZINE | | Descriptor: | 1,2-ETHANEDIOL, 1-[4-[2-(4-methoxyphenyl)-5-methyl-pyrrolo[2,3-b]pyrazin-6-yl]piperidin-1-yl]ethanone, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Benz, J, Ehler, A, Hug, M, Huber, S, Rufer, A.C, Guba, W, Jagasia, R, Hofmann, E.C, Rodriguez Sarmiento, R.M. | | Deposit date: | 2019-10-03 | | Release date: | 2020-12-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Novel beta-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.
Angew.Chem.Int.Ed.Engl., 60, 2021
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6WQK
 | | hnRNPA2 Low complexity domain (LCD) determined by cryoEM | | Descriptor: | MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera | | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | | Deposit date: | 2020-04-29 | | Release date: | 2020-08-26 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
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6WPQ
 | | GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant | | Descriptor: | Heterogeneous nuclear ribonucleoprotein A2 | | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | | Deposit date: | 2020-04-27 | | Release date: | 2020-08-19 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
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6ST5
 | | crystal structure of LicM2 | | Descriptor: | GLYCEROL, LicM2, MAGNESIUM ION, ... | | Authors: | Gonsior, M, Mainz, A, Hugelland, M, Kuthning, A, Tietzmann, M, Dobbek, H, Martins, B.M, Sussmuth, R. | | Deposit date: | 2019-09-10 | | Release date: | 2022-08-10 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | crystal structure of LicM2
To Be Published
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5MY3
 | | Crystal structure of the RhoGAP domain of Rgd1p at 2.19 Angstroms resolution | | Descriptor: | RHO GTPase-activating protein RGD1 | | Authors: | Martinez, D.M, d'Estaintot, B.L, Granier, T, Hugues, M, Odaert, B, Gallois, B, Doignon, F. | | Deposit date: | 2017-01-25 | | Release date: | 2018-01-24 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Structural evidence of a phosphoinositide-binding site in the Rgd1-RhoGAP domain.
Biochem. J., 474, 2017
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1CBG
 | | THE CRYSTAL STRUCTURE OF A CYANOGENIC BETA-GLUCOSIDASE FROM WHITE CLOVER (TRIFOLIUM REPENS L.), A FAMILY 1 GLYCOSYL-HYDROLASE | | Descriptor: | CYANOGENIC BETA-GLUCOSIDASE | | Authors: | Barrett, T.E, Suresh, C.G, Tolley, S.P, Hughes, M.A. | | Deposit date: | 1995-07-31 | | Release date: | 1995-10-15 | | Last modified: | 2019-08-14 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The crystal structure of a cyanogenic beta-glucosidase from white clover, a family 1 glycosyl hydrolase.
Structure, 3, 1995
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