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PDB: 705 results

3VDC
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BU of 3vdc by Molmil
E. coli (lacZ) beta-galactosidase (N460T) in complex with IPTG
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ...
Authors:Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VD9
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BU of 3vd9 by Molmil
E. coli (lacZ) beta-galactosidase (N460S) in complex with IPTG
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ...
Authors:Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3VD3
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BU of 3vd3 by Molmil
E. coli (lacZ) beta-galactosidase (N460D)
Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
Authors:Wheatley, R.W, Kappelhoff, J.C, Hahn, J.N, Dugdale, M.L, Dutkoski, M.J, Tamman, S.D, Fraser, M.E, Huber, R.E.
Deposit date:2012-01-04
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substitution for Asn460 cripples {beta}-galactosidase (Escherichia coli) by increasing substrate affinity and decreasing transition state stability.
Arch.Biochem.Biophys., 521, 2012
3T0D
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BU of 3t0d by Molmil
E.coli (lacZ) beta-galactosidase (S796T) in complex with galactonolactone
Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ...
Authors:Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E.
Deposit date:2011-07-20
Release date:2012-01-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Ser-796 of Beta-galactosidase (E. coli) plays a Key role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop
Arch.Biochem.Biophys., 517, 2012
3T2O
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BU of 3t2o by Molmil
E. coli (lacZ) beta-galactosidase (S796D)
Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
Authors:Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E.
Deposit date:2011-07-22
Release date:2012-01-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop
Arch.Biochem.Biophys., 517, 2012
3T09
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BU of 3t09 by Molmil
E. coli (LacZ) beta-galactosidase (S796A) galactonolactone complex
Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ...
Authors:Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E.
Deposit date:2011-07-19
Release date:2012-01-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop
Arch.Biochem.Biophys., 517, 2012
3T08
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BU of 3t08 by Molmil
E. coli (LacZ) beta-galactosidase (S796A) IPTG complex
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ...
Authors:Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E.
Deposit date:2011-07-19
Release date:2012-01-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop
Arch.Biochem.Biophys., 517, 2012
3RGF
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BU of 3rgf by Molmil
Crystal Structure of human CDK8/CycC
Descriptor: 1,2-ETHANEDIOL, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Cyclin-C, ...
Authors:Schneider, E.V, Boettcher, J, Blaesse, M, Huber, R, Maskos, K.
Deposit date:2011-04-08
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder.
J.Mol.Biol., 412, 2011
3NZW
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BU of 3nzw by Molmil
Crystal structure of the yeast 20S proteasome in complex with 2b
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Gallastegui, N, Marechal, X, Le Ravalec, V, Basse, N, Richy, N, Genin, E, Huber, R, Moroder, M, Vidal, V, Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZX
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BU of 3nzx by Molmil
Crystal structure of the yeast 20S proteasome in complex with ligand 2c
Descriptor: Proteasome component C1, Proteasome component C11, Proteasome component C5, ...
Authors:Groll, M, Gallastegui, N, Marechal, X, Le Ravalec, V, Basse, N, Richy, N, Genin, E, Huber, R, Moroder, M, Vidal, V, Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3OKJ
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BU of 3okj by Molmil
Alpha-keto-aldehyde binding mechanism reveals a novel lead structure motif for proteasome inhibition
Descriptor: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S,3S)-3-hydroxy-1-(4-hydroxyphenyl)-4-oxobutan-2-yl]-L-leucinamide, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Poynor, M, Gallastegui, P, Stein, M, Schmidt, B, Kloetzel, P.M, Huber, R.
Deposit date:2010-08-25
Release date:2011-06-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Elucidation of the alpha-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition
Angew.Chem.Int.Ed.Engl., 50, 2011
3I3B
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BU of 3i3b by Molmil
E.coli (lacz) Beta-Galactosidase (M542A) in Complex with D-Galactopyranosyl-1-on
Descriptor: Beta-galactosidase, D-galactonolactone, DIMETHYL SULFOXIDE, ...
Authors:Dugdale, M.L, Dymianiw, D, Minhas, B, Huber, R.E.
Deposit date:2009-06-30
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase (Escherichia coli).
Biochem.Cell Biol., 88, 2010
3I3D
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BU of 3i3d by Molmil
E. COLI (lacZ) BETA-GALACTOSIDASE (M542A) IN COMPLEX WITH IPTG
Descriptor: 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ...
Authors:Dugdale, M.L, Dymianiw, D, Minhas, B, Huber, R.E.
Deposit date:2009-06-30
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase (Escherichia coli).
Biochem.Cell Biol., 88, 2010
3I3E
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BU of 3i3e by Molmil
E. COLI (lacZ) BETA-GALACTOSIDASE (M542A)
Descriptor: Beta-galactosidase, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
Authors:Dugdale, M.L, Dymianiw, D, Minhas, B, Huber, R.E.
Deposit date:2009-06-30
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of Met-542 as a guide for the conformational changes of Phe-601 that occur during the reaction of β-galactosidase (Escherichia coli).
Biochem.Cell Biol., 88, 2010
3MN5
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BU of 3mn5 by Molmil
Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A.
Deposit date:2010-04-21
Release date:2010-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.
Proc.Natl.Acad.Sci.USA, 107, 2010
3NZJ
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BU of 3nzj by Molmil
Crystal structure of yeast 20S proteasome in complex with ligand 2a
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Gallastegui, N, Marechal, X, Le Ravalec, V, Basse, N, Richy, N, Genin, E, Huber, R, Moroder, M, Vidal, V, Reboud-Ravaux, M.
Deposit date:2010-07-16
Release date:2011-02-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3MN9
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BU of 3mn9 by Molmil
Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ...
Authors:Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A.
Deposit date:2010-04-21
Release date:2010-05-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MN7
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BU of 3mn7 by Molmil
Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, CALCIUM ION, ...
Authors:Ducka, A.M, Sitar, T, Popowicz, G.M, Huber, R, Holak, T.A.
Deposit date:2010-04-21
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.
Proc.Natl.Acad.Sci.USA, 107, 2010
3SHJ
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BU of 3shj by Molmil
Proteasome in complex with hydroxyurea derivative HU10
Descriptor: 1-hydroxy-1-[(2R)-4-{3-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yloxy]phenyl}but-3-yn-2-yl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proteasome component C1, ...
Authors:Gallastegui, N, Beck, P, Arciniega, M, Hillebrand, S, Huber, R, Groll, M.
Deposit date:2011-06-16
Release date:2011-12-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Hydroxyureas as noncovalent proteasome inhibitors.
Angew.Chem.Int.Ed.Engl., 51, 2012
1VLB
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BU of 1vlb by Molmil
STRUCTURE REFINEMENT OF THE ALDEHYDE OXIDOREDUCTASE FROM DESULFOVIBRIO GIGAS AT 1.28 A
Descriptor: (MOLYBDOPTERIN-CYTOSINE DINUCLEOTIDE-S,S)-DIOXO-AQUA-MOLYBDENUM(V), ALDEHYDE OXIDOREDUCTASE, CHLORIDE ION, ...
Authors:Rebelo, J.M, Dias, J.M, Huber, R, Moura, J.J.G, Romao, M.J.
Deposit date:2004-07-20
Release date:2004-07-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structure refinement of the aldehyde oxidoreductase from Desulfovibrio gigas (MOP) at 1.28 A
J.Biol.Inorg.Chem., 6, 2001
2UX7
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BU of 2ux7 by Molmil
Pseudoazurin with engineered amicyanin ligand loop, reduced form, pH 7.5
Descriptor: CHLORIDE ION, COPPER (II) ION, GLYCEROL, ...
Authors:Velarde, M, Huber, R, Yanagisawa, S, Dennison, C, Messerschmidt, A.
Deposit date:2007-03-27
Release date:2007-08-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Influence of loop shortening on the metal binding site of cupredoxin pseudoazurin.
Biochemistry, 46, 2007
1XHA
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BU of 1xha by Molmil
Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
Descriptor: N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B.
Deposit date:2004-09-17
Release date:2005-09-17
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants
J.Med.Chem., 48, 2005
2UX6
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BU of 2ux6 by Molmil
Pseudoazurin with engineered amicyanin ligand loop, oxidized form, pH 7.5
Descriptor: CHLORIDE ION, COPPER (II) ION, GLYCEROL, ...
Authors:Velarde, M, Huber, R, Yanagisawa, S, Dennison, C, Messerschmidt, A.
Deposit date:2007-03-27
Release date:2007-08-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Influence of Loop Shortening on the Metal Binding Site of Cupredoxin Pseudoazurin.
Biochemistry, 46, 2007
1XH8
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BU of 1xh8 by Molmil
Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
Descriptor: N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B.
Deposit date:2004-09-17
Release date:2005-09-17
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants
J.Med.Chem., 48, 2005
1XH6
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BU of 1xh6 by Molmil
Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
Descriptor: N-(4-{[4-(2-HYDROXY-5-PIPERIDIN-1-YLBENZOYL)BENZOYL]AMINO}AZEPAN-3-YL)ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ...
Authors:Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B.
Deposit date:2004-09-17
Release date:2005-09-17
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants
J.Med.Chem., 48, 2005

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