9CMR
 
 | | Saccharomyces cerevisiae Tom1 HECT domain | | Descriptor: | E3 ubiquitin-protein ligase TOM1, SULFATE ION | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-15 | | Release date: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters.
To Be Published
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9CTM
 | | Condensing region of EcPKS2 - acetylated dataset | | Descriptor: | Polyketide synthase 2 | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9CTN
 | | Modifying region of EcPKS2 - acetylated dataset | | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase 2, ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] ethanethioate | | Authors: | Schubert, H.L, Hill, C.P, Li, F, Schmidt, E.W. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9CTI
 | | Condensing region of EcPKS2 - malonylCoA inhibited dataset | | Descriptor: | EcPKS2 - condensing domain bound to malonyl-CoA and malonyl, MALONYL-COENZYME A | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9CTK
 | | Modifying region of EcPKS2 - malonylCoA inhibited dataset | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase 2 | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9CTL
 | | Full length EcPKS2 - malonylCoA inhibited dataset | | Descriptor: | MALONYL-COENZYME A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase 2 | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9CQ1
 | | Condensing region of EcPKS1 | | Descriptor: | EcPKS1 - condensing region | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9CTO
 | | Full length EcPKS2 - acylated dataset with three ACP positions | | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase 2, ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] ethanethioate | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-25 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9CQ9
 | | Modifying region of EcPKS1 | | Descriptor: | Polyketide synthase 1 | | Authors: | Schubert, H.L, Hill, C.P. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.
Proc.Natl.Acad.Sci.USA, 122, 2025
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1CBF
 | | THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF | | Descriptor: | COBALT-PRECORRIN-4 TRANSMETHYLASE, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Schubert, H.L, Raux, E, Woodcock, S.C, Wilson, K.S, Warren, M.J. | | Deposit date: | 1998-05-01 | | Release date: | 1999-05-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase.
Nat.Struct.Biol., 5, 1998
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1YTS
 | | A LIGAND-INDUCED CONFORMATIONAL CHANGE IN THE YERSINIA PROTEIN TYROSINE PHOSPHATASE | | Descriptor: | SULFATE ION, YERSINIA PROTEIN TYROSINE PHOSPHATASE | | Authors: | Schubert, H.L, Stuckey, J.A, Fauman, E.B, Dixon, J.E, Saper, M.A. | | Deposit date: | 1995-04-07 | | Release date: | 1995-07-10 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.
Protein Sci., 4, 1995
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2CBF
 | | THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF, FROM BACILLUS MEGATERIUM, WITH THE HIS-TAG CLEAVED OFF | | Descriptor: | COBALT-PRECORRIN-4 TRANSMETHYLASE, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Schubert, H.L, Raux, E, Woodcock, S.C, Warren, M.J, Wilson, K.S. | | Deposit date: | 1998-05-01 | | Release date: | 1999-05-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase.
Nat.Struct.Biol., 5, 1998
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3NWH
 | | Crystal structure of BST2/Tetherin | | Descriptor: | Bone marrow stromal antigen 2 | | Authors: | Schubert, H.L, Zhai, Q, Hill, C.P. | | Deposit date: | 2010-07-09 | | Release date: | 2010-07-21 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.
Proc.Natl.Acad.Sci.USA, 107, 2010
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1QGO
 | | ANAEROBIC COBALT CHELATASE IN COBALAMIN BIOSYNTHESIS FROM SALMONELLA TYPHIMURIUM | | Descriptor: | ANAEROBIC COBALAMIN BIOSYNTHETIC COBALT CHELATASE, SULFATE ION | | Authors: | Schubert, H.L, Raux, E, Warren, M.J, Wilson, K.S. | | Deposit date: | 1999-05-03 | | Release date: | 1999-09-29 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis.
Biochemistry, 38, 1999
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1A6E
 | | THERMOSOME-MG-ADP-ALF3 COMPLEX | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | Authors: | Ditzel, L, Loewe, J, Stock, D, Stetter, K.-O, Huber, H, Huber, R, Steinbacher, S. | | Deposit date: | 1998-02-24 | | Release date: | 1999-03-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT.
Cell(Cambridge,Mass.), 93, 1998
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1A6D
 | | THERMOSOME FROM T. ACIDOPHILUM | | Descriptor: | THERMOSOME (ALPHA SUBUNIT), THERMOSOME (BETA SUBUNIT) | | Authors: | Ditzel, L, Loewe, J, Stock, D, Stetter, K.-O, Huber, H, Huber, R, Steinbacher, S. | | Deposit date: | 1998-02-24 | | Release date: | 1999-03-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT.
Cell(Cambridge,Mass.), 93, 1998
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3MMC
 | | Structure of the dissimilatory sulfite reductase from Archaeoglobus fulgidus | | Descriptor: | GLYCEROL, IRON/SULFUR CLUSTER, SIROHEME, ... | | Authors: | Schiffer, A, Parey, K, Warkentin, E, Diederichs, K, Huber, H, Stetter, K.O, Kroneck, P.M.H, Ermler, U. | | Deposit date: | 2010-04-19 | | Release date: | 2010-05-12 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structure of the dissimilatory sulfite reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus.
J.Mol.Biol., 379, 2008
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1JNZ
 | | Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6 resolution | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, IRON/SULFUR CLUSTER, SULFITE ION, ... | | Authors: | Fritz, G, Roth, A, Schiffer, A, Buechert, T, Bourenkov, G, Bartunik, H.D, Huber, H, Stetter, K.O, Kroneck, P.M, Ermler, U. | | Deposit date: | 2001-07-26 | | Release date: | 2002-03-27 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
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1JNR
 | | Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6 resolution | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, IRON/SULFUR CLUSTER, ... | | Authors: | Fritz, G, Roth, A, Schiffer, A, Buechert, T, Bourenkov, G, Bartunik, H.D, Huber, H, Stetter, K.O, Kroneck, P.M.H, Ermler, U. | | Deposit date: | 2001-07-25 | | Release date: | 2002-02-27 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-A resolution
Proc.Natl.Acad.Sci.USA, 99, 2002
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1MZC
 | | Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a | | Descriptor: | 2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE, FARNESYL DIPHOSPHATE, Protein Farnesyltransferase alpha Subunit, ... | | Authors: | deSolms, S.J, Ciccarone, T.M, MacTough, S.C, Shaw, A.W, Buser, C.A, Ellis-Hutchings, M, Fernandes, C, Hamilton, K.A, Huber, H.E, Kohl, N.E, Lobell, R.B, Robinson, R.G, Tsou, N.N, Walsh, E.S, Graham, S.L, Beese, L.S, Taylor, J.S. | | Deposit date: | 2002-10-07 | | Release date: | 2003-07-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.
J.Med.Chem., 46, 2003
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1Q0B
 | | Crystal structure of the motor protein KSP in complex with ADP and monastrol | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE, Kinesin-like protein KIF11, ... | | Authors: | Yan, Y, Sardana, V, Xu, B, Halczenko, W, Homnick, C, Buser, C.A, Hartman, G.D, Huber, H.E, Kuo, L.C. | | Deposit date: | 2003-07-15 | | Release date: | 2004-01-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Inhibition of a mitotic motor protein: where, how, and conformational consequences
J.Mol.Biol., 335, 2004
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8U7T
 | | Substrate-bound Cdc48, Class 1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Lin, H.J.L, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-15 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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6PEK
 | | Structure of Spastin Hexamer (Subunit A-E) in complex with substrate peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2019-06-20 | | Release date: | 2019-12-04 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
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6PEN
 | | Structure of Spastin Hexamer (whole model) in complex with substrate peptide | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, EYEYEYEYEY, ... | | Authors: | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | | Deposit date: | 2019-06-20 | | Release date: | 2019-12-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
J.Biol.Chem., 295, 2020
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8U8I
 | | Cdc48-Shp1 unfolding native substrate, Class 4 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48, MAGNESIUM ION, ... | | Authors: | Cooney, I, Schubert, H.L, Cedeno, K, Carson, R, Fisher, O.N, Price, J.C, Hill, C.P, Shen, P.S. | | Deposit date: | 2023-09-18 | | Release date: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.
Nat Commun, 15, 2024
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