8WIK
| Crystal structure of human FSP1 | 分子名称: | 6-HYDROXY-FLAVIN-ADENINE DINUCLEOTIDE, Ferroptosis suppressor protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Feng, S, Huang, X, Tang, D, Qi, S. | 登録日 | 2023-09-24 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide. MedComm (2020), 5, 2024
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9AXM
| Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer | 分子名称: | 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 1, GLYCEROL, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXX
| Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AYA
| Crystal structure of CRAF/MEK complex with NST-628 and active RAF dimer | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXY
| Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF | 分子名称: | Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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9AXA
| CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628 | 分子名称: | 14-3-3 protein sigma, Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, ... | 著者 | Quade, B, Cohen, S.E, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.36 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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5GNS
| Structures of human Mitofusin 1 provide insight into mitochondrial tethering | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Mitofusin-1 | 著者 | Qi, Y, Yan, L, Yu, C, Guo, X, Zhou, X, Hu, X, Huang, X, Rao, Z, Lou, Z, Hu, J. | 登録日 | 2016-07-24 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | Structures of human Mitofusin 1 provide insight into mitochondrial tethering To Be Published
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4E55
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4E57
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4E56
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5J97
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6OGE
| Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab FAB HEAVY CHAIN, Pertuzumab FAB LIGHT CHAIN, ... | 著者 | Hao, Y, Yu, X, Bai, Y, Huang, X. | 登録日 | 2019-04-02 | 公開日 | 2019-05-15 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.36 Å) | 主引用文献 | Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex. Plos One, 14, 2019
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4GID
| Structure of beta-secretase complexed with inhibitor | 分子名称: | Beta-secretase 1, L-PROLINAMIDE, N-[(2S)-1-({(2S,3R)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl}amino)-3-phenylpropan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide | 著者 | Ghosh, A, Tang, J, Venkateswara, R.K, Yadav, N, Anderson, D, Gavande, N, Huang, X, Terzyan, S. | 登録日 | 2012-08-08 | 公開日 | 2012-10-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based design of highly selective beta-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. J.Med.Chem., 55, 2012
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4L9C
| Crystal structure of the FP domain of human F-box protein Fbxo7 (native) | 分子名称: | F-box only protein 7, GLYCEROL | 著者 | Du, Z, Huang, X, Shang, J, Yang, Y, Wang, G. | 登録日 | 2013-06-18 | 公開日 | 2014-01-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction. Acta Crystallogr.,Sect.D, 70, 2014
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4L9H
| Crystal structure of the FP domain of human F-box protein Fbxo7(SeMet) | 分子名称: | F-box only protein 7 | 著者 | Du, Z, Huang, X, Shang, J, Yang, Y, Wang, G. | 登録日 | 2013-06-18 | 公開日 | 2014-01-15 | 最終更新日 | 2014-10-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction. Acta Crystallogr.,Sect.D, 70, 2014
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4NLH
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8KDC
| Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form | 分子名称: | MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... | 著者 | Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. | 登録日 | 2023-08-09 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
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8KDB
| Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form | 分子名称: | MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... | 著者 | Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. | 登録日 | 2023-08-09 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
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4OUH
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3IZ3
| CryoEM structure of cytoplasmic polyhedrosis virus | 分子名称: | Structural protein VP1, Structural protein VP3, Viral structural protein 5 | 著者 | Cheng, L, Sun, J, Zhang, K, Mou, Z, Huang, X, Ji, G, Sun, F, Zhang, J, Zhu, P. | 登録日 | 2010-09-14 | 公開日 | 2011-03-16 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping. Proc.Natl.Acad.Sci.USA, 108, 2011
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5CFB
| Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-3,Glycine receptor subunit alpha-3, ... | 著者 | Shaffer, P.L, Huang, X, Chen, H. | 登録日 | 2015-07-08 | 公開日 | 2015-09-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | Crystal structure of human glycine receptor-alpha 3 bound to antagonist strychnine. Nature, 526, 2015
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6C45
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3S1R
| RNA Polymerase II Initiation Complex with a 5-nt 3'-deoxy RNA soaked with GTP | 分子名称: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | 著者 | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | 登録日 | 2011-05-16 | 公開日 | 2011-08-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3S16
| RNA Polymerase II Initiation Complex with an 8-nt RNA | 分子名称: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | 著者 | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | 登録日 | 2011-05-14 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.241 Å) | 主引用文献 | Initiation complex structure and promoter proofreading. Science, 333, 2011
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3S14
| RNA Polymerase II Initiation Complex with a 6-nt RNA | 分子名称: | DNA (5'-D(*CP*TP*AP*CP*CP*GP*AP*TP*AP*AP*GP*CP*AP*GP*AP*CP*GP*AP*TP*CP*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | 著者 | Liu, X, Bushnell, D.A, Silva, D.A, Huang, X, Kornberg, R.D. | 登録日 | 2011-05-14 | 公開日 | 2011-08-10 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Initiation complex structure and promoter proofreading. Science, 333, 2011
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