3EZV
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![BU of 3ezv by Molmil](/molmil-images/mine/3ezv) | CDK-2 with indazole inhibitor 9 bound at its active site | Descriptor: | 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2 | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | Deposit date: | 2008-10-23 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor Bioorg.Med.Chem.Lett., 19, 2009
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1J8E
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![BU of 1j8e by Molmil](/molmil-images/mine/1j8e) | Crystal structure of ligand-binding repeat CR7 from LRP | Descriptor: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1 | Authors: | Simonovic, M, Dolmer, K, Huang, W, Strickland, D.K, Volz, K, Gettins, P.G.W. | Deposit date: | 2001-05-21 | Release date: | 2001-12-19 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor. Biochemistry, 40, 2001
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1JRF
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![BU of 1jrf by Molmil](/molmil-images/mine/1jrf) | NMR Solution Structure of the Viral Receptor Domain of Tva | Descriptor: | CALCIUM ION, SUBGROUP A ROUS SARCOMA VIRUS RECEPTORS PG800 AND PG950 | Authors: | Wang, Q.-Y, Huang, W, Dolmer, K, Gettins, P.G.W, Rong, L. | Deposit date: | 2001-08-13 | Release date: | 2002-03-08 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of the viral receptor domain of Tva and its implications in viral entry. J.Virol., 76, 2002
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1YIS
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![BU of 1yis by Molmil](/molmil-images/mine/1yis) | Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase | Descriptor: | SULFATE ION, adenylosuccinate lyase | Authors: | Symersky, J, Schormann, N, Lu, S, Zhang, Y, Karpova, E, Qiu, S, Huang, W, Cao, Z, Zhou, J, Luo, M, Arabshahi, A, McKinstry, A, Luan, C.-H, Luo, D, Johnson, D, An, J, Tsao, J, Delucas, L, Shang, Q, Gray, R, Li, S, Bray, T, Chen, Y.-J, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2005-01-12 | Release date: | 2005-01-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural genomics of Caenorhabditis elegans: adenylosuccinate lyase To be Published
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2B34
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![BU of 2b34 by Molmil](/molmil-images/mine/2b34) | Structure of MAR1 Ribonuclease from Caenorhabditis elegans | Descriptor: | MAR1 Ribonuclease | Authors: | Schormann, N, Karpova, E, Li, S, Symersky, J, Zhang, Y, Lu, S, Zhou, Q, Lin, G, Cao, Z, Luo, M, Qiu, S, Luan, C.-H, Luo, D, Huang, W, Shang, Q, McKinstry, A, An, J, Tsao, J, Carson, M, Stinnett, M, Chen, Y, Johnson, D, Gary, R, Arabshahi, A, Bunzel, R, Bray, T, DeLucas, L, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2005-09-19 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.141 Å) | Cite: | Structure of MAR1 Ribonuclease from Caenorhabditis elegans To be Published
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7C2E
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![BU of 7c2e by Molmil](/molmil-images/mine/7c2e) | GLP-1R-Gs complex structure with a small molecule full agonist | Descriptor: | 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E. | Deposit date: | 2020-05-07 | Release date: | 2020-08-26 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res., 30, 2020
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8K6Z
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![BU of 8k6z by Molmil](/molmil-images/mine/8k6z) | NMR structure of human leptin | Descriptor: | Leptin | Authors: | Fan, X, Qin, R, Yuan, W, Fan, J, Huang, W, Lin, Z. | Deposit date: | 2023-07-26 | Release date: | 2024-02-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The solution structure of human leptin reveals a conformational plasticity important for receptor recognition. Structure, 32, 2024
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2PGH
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![BU of 2pgh by Molmil](/molmil-images/mine/2pgh) | STRUCTURE DETERMINATION OF AQUOMET PORCINE HEMOGLOBIN AT 2.8 ANGSTROM RESOLUTION | Descriptor: | HEMOGLOBIN (AQUO MET) (ALPHA CHAIN), HEMOGLOBIN (AQUO MET) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE | Authors: | Katz, D.S, White, S.P, Huang, W, Kumar, R, Christianson, D.W. | Deposit date: | 1994-09-16 | Release date: | 1994-11-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure determination of aquomet porcine hemoglobin at 2.8 A resolution. J.Mol.Biol., 244, 1994
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3JBT
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![BU of 3jbt by Molmil](/molmil-images/mine/3jbt) | Atomic structure of the Apaf-1 apoptosome | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ... | Authors: | Zhou, M, Li, Y, Hu, Q, Bai, X, Huang, W, Yan, C, Scheres, S.H.W, Shi, Y. | Deposit date: | 2015-10-15 | Release date: | 2015-11-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1 Genes Dev., 29, 2015
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7T2H
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![BU of 7t2h by Molmil](/molmil-images/mine/7t2h) | CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Seven, A.B, Qu, Q, Huang, W, Robertson, M.J, Kobilka, B.K, Skiniotis, G. | Deposit date: | 2021-12-04 | Release date: | 2022-12-07 | Last modified: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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7TUY
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![BU of 7tuy by Molmil](/molmil-images/mine/7tuy) | Cryo-EM structure of GSK682753A-bound EBI2/GPR183 | Descriptor: | 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ... | Authors: | Chen, H, Huang, W, Li, X. | Deposit date: | 2022-02-03 | Release date: | 2022-04-13 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure, 30, 2022
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8INV
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![BU of 8inv by Molmil](/molmil-images/mine/8inv) | Crystal structure of UGT74AN3-UDP-BUF | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Glycosyltransferase, URIDINE-5'-DIPHOSPHATE, ... | Authors: | Long, F, Huang, W. | Deposit date: | 2023-03-10 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 Acs Catalysis, 14, 2024
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8INA
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![BU of 8ina by Molmil](/molmil-images/mine/8ina) | Crystal structure of UGT74AN3-UDP | Descriptor: | GLYCEROL, Glycosyltransferase, URIDINE-5'-DIPHOSPHATE | Authors: | Long, F, Huang, W. | Deposit date: | 2023-03-09 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 Acs Catalysis, 14, 2024
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8INO
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![BU of 8ino by Molmil](/molmil-images/mine/8ino) | Crystal structure of UGT74AN3 in complex UDP and PER | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[(3S,5S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3,5,14-tris(oxidanyl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2H-furan-5-one, Glycosyltransferase, ... | Authors: | Long, F, Huang, W. | Deposit date: | 2023-03-10 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Substrate Promiscuity, Crystal Structure, and Application of a Plant UDP-Glycosyltransferase UGT74AN3 Acs Catalysis, 14, 2024
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2M0M
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![BU of 2m0m by Molmil](/molmil-images/mine/2m0m) | Structural Characterization of Minor Ampullate Spidroin Domains and their Distinct Roles in Fibroin Solubility and Fiber Formation | Descriptor: | Minor ampullate fibroin 1 | Authors: | Yang, D, Gao, Z, Lin, Z, Huang, W, Lai, C, Fan, J. | Deposit date: | 2012-10-30 | Release date: | 2013-03-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural characterization of minor ampullate spidroin domains and their distinct roles in fibroin solubility and fiber formation Plos One, 8, 2013
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2LYI
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8FCK
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![BU of 8fck by Molmil](/molmil-images/mine/8fck) | Structure of the vertebrate augmin complex | Descriptor: | HAUS augmin like complex subunit 2 L homeolog, Green fluorescent protein chimera, HAUS augmin like complex subunit 4 L homeolog, ... | Authors: | Travis, S.M, Huang, W, Zhang, R, Petry, S. | Deposit date: | 2022-12-01 | Release date: | 2023-04-19 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (6.88 Å) | Cite: | Integrated model of the vertebrate augmin complex. Nat Commun, 14, 2023
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4IU9
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![BU of 4iu9 by Molmil](/molmil-images/mine/4iu9) | Crystal structure of a membrane transporter | Descriptor: | Nitrite extrusion protein 2 | Authors: | Yan, H, Huang, W, Yan, C, Gong, X, Jiang, S, Zhao, Y, Wang, J, Shi, Y. | Deposit date: | 2013-01-20 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.005 Å) | Cite: | Structure and mechanism of a nitrate transporter. Cell Rep, 3, 2013
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4IU8
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![BU of 4iu8 by Molmil](/molmil-images/mine/4iu8) | Crystal structure of a membrane transporter (selenomethionine derivative) | Descriptor: | NITRATE ION, Nitrite extrusion protein 2 | Authors: | Yan, H, Huang, W, Yan, C, Gong, X, Jiang, S, Zhao, Y, Wang, J, Shi, Y. | Deposit date: | 2013-01-20 | Release date: | 2013-04-17 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structure and mechanism of a nitrate transporter. Cell Rep, 3, 2013
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2K3N
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1PGV
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![BU of 1pgv by Molmil](/molmil-images/mine/1pgv) | Structural Genomics of Caenorhabditis elegans: tropomodulin C-terminal domain | Descriptor: | tropomodulin TMD-1 | Authors: | Symersky, J, Lu, S, Li, S, Chen, L, Meehan, E, Luo, M, Qiu, S, Bunzel, R.J, Luo, D, Arabashi, A, Nagy, L.A, Lin, G, Luan, W.C.-H, Carson, M, Gray, R, Huang, W, Southeast Collaboratory for Structural Genomics (SECSG) | Deposit date: | 2003-05-28 | Release date: | 2003-06-10 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural genomics of Caenorhabditis elegans: crystal structure of the tropomodulin C-terminal domain Proteins, 56, 2004
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2K3O
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![BU of 2k3o by Molmil](/molmil-images/mine/2k3o) | |
6JM5
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![BU of 6jm5 by Molmil](/molmil-images/mine/6jm5) | Crystal structure of TBC1D23 C terminal domain | Descriptor: | SODIUM ION, TBC1 domain family member 23 | Authors: | Sun, Q, Huang, W. | Deposit date: | 2019-03-07 | Release date: | 2019-10-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proc.Natl.Acad.Sci.USA, 116, 2019
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2K53
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![BU of 2k53 by Molmil](/molmil-images/mine/2k53) | NMR solution structure of A3DK08 protein from Clostridium thermocellum: Northeast Structural Genomics Consortium Target CmR9 | Descriptor: | A3DK08 Protein | Authors: | Swapna, G.V.T, Huang, W, Jiang, M, Foote, E.L, Xiao, R, Nair, R, Everett, J, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-06-24 | Release date: | 2008-08-19 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR Solution Structure of A3DK08 protein from Clostridium thermocellum: Northeast Structural Genomics Consortium Target CmR9 To be Published
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5KU3
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![BU of 5ku3 by Molmil](/molmil-images/mine/5ku3) | BRD4 bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone) | Descriptor: | 1,2-ETHANEDIOL, 1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone, Bromodomain-containing protein 4, ... | Authors: | Murray, J.M, Huang, W. | Deposit date: | 2016-07-12 | Release date: | 2016-11-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. J. Med. Chem., 59, 2016
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