5H73
| Crystal structure of human DHODH with 18F | Descriptor: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Huang, J, Wu, D. | Deposit date: | 2016-11-16 | Release date: | 2017-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structure of human DHODH with 18F at 1.58 Angstroms resolution To Be Published
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5HIN
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L compound | Descriptor: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Huang, J, Wu, D, Lu, Q, Yao, X. | Deposit date: | 2016-01-12 | Release date: | 2016-07-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L at 1.60 A resolution To Be Published
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5HQE
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6KIX
| Cryo-EM structure of human MLL1-NCP complex, binding mode1 | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIV
| Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIZ
| Cryo-EM structure of human MLL1-NCP complex, binding mode2 | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIU
| Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | Descriptor: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | Authors: | Huang, J, Xue, H, Yao, T. | Deposit date: | 2019-07-20 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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4AGH
| Structural features of ssDNA binding protein MoSub1 from Magnaporthe oryzae | Descriptor: | MOSUB1, TRANSCRIPTION COFACTOR | Authors: | Huang, J, Zhao, Y, Huang, D, liu, J, Peng, Y. | Deposit date: | 2012-01-27 | Release date: | 2012-08-29 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.787 Å) | Cite: | Structural Features of the Single-Stranded DNA-Binding Protein Mosub1 from Magnaporthe Oryzae. Acta Crystallogr.,Sect.D, 68, 2012
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4BHM
| The crystal structure of MoSub1-DNA complex reveals a novel DNA binding mode | Descriptor: | 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP)-3', MOSUB1 TRANSCRIPTION COFACTOR, SULFATE ION | Authors: | Huang, J, Liu, H, Zhao, Y, Huang, D, liu, J, Peng, Y. | Deposit date: | 2013-04-04 | Release date: | 2014-04-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4. Sci.Rep., 5, 2015
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6W16
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6WCV
| Tartryl-CoA bound to human GTP-specific succinyl-CoA synthetase | Descriptor: | (3S,5S,9R,20R,21R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,20, 21-pentahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphadocosan-22-oic acid 3,5-dioxide (non-preferred name), Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, ... | Authors: | Huang, J, Fraser, M.E. | Deposit date: | 2020-03-31 | Release date: | 2020-07-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Tartryl-CoA inhibits succinyl-CoA synthetase Acta Crystallogr.,Sect.F, 76, 2020
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6XRU
| GTP-specific succinyl-CoA synthetase complexed with desulfo-coenzyme A, magnesium ions and succinates | Descriptor: | 1,2-ETHANEDIOL, DESULFO-COENZYME A, GLYCEROL, ... | Authors: | Huang, J, Fraser, M.E. | Deposit date: | 2020-07-13 | Release date: | 2021-03-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Second distinct conformation of the phosphohistidine loop in succinyl-CoA synthetase Acta Crystallogr.,Sect.D, 77, 2021
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8H7G
| Cryo-EM structure of the human SAGA complex | Descriptor: | Ataxin-7, STAGA complex 65 subunit gamma, Splicing factor 3B subunit 3, ... | Authors: | Huang, J, Zhang, Y. | Deposit date: | 2022-10-20 | Release date: | 2022-12-14 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of human SAGA transcriptional coactivator complex. Cell Discov, 8, 2022
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8JB4
| lipopolysaccharide-binding domain-LBDB | Descriptor: | Antilipopolysaccharide factor D | Authors: | Huang, J, Qin, Z. | Deposit date: | 2023-05-08 | Release date: | 2024-03-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Machine learning and genetic algorithm-guided directed evolution for the development of small-molecule antibiotics originating from antimicrobial peptides To Be Published
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8EJM
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5BPP
| Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ | Descriptor: | 2-(4-butoxyphenyl)-N-hydroxyacetamide, ACETATE ION, Leukotriene A-4 hydrolase, ... | Authors: | Huang, J, Dong, N.N, Xiao, Q, Ou, P.Y, Wu, D, Lu, W.Q. | Deposit date: | 2015-05-28 | Release date: | 2016-08-10 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H Sci Rep, 6, 2016
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6EE7
| Small tetraheme cytochrome c from Shewanella oneidensis | Descriptor: | HEME C, Periplasmic tetraheme cytochrome c CctA, ZINC ION | Authors: | Huang, J, Zarzycki, J, Ducat, D.C, Kramer, D.M. | Deposit date: | 2018-08-13 | Release date: | 2019-08-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.394 Å) | Cite: | Mesoscopic to Macroscopic Electron Transfer by Hopping in a Crystal Network of Cytochromes. J.Am.Chem.Soc., 142, 2020
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8E15
| A computationally stabilized hMPV F protein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F1 protein with Fibritin peptide, F2 protein, ... | Authors: | Huang, J, Gonzalez, K, Mousa, J, Strauch, E. | Deposit date: | 2022-08-09 | Release date: | 2023-04-12 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | A general computational design strategy for stabilizing viral class I fusion proteins. Nat Commun, 15, 2024
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4ZL1
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18X at 1.86 A resolution | Descriptor: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | Authors: | Huang, J, Wu, D, Ouyang, P, Lu, W, Pu, J. | Deposit date: | 2015-05-01 | Release date: | 2016-05-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18XYW at 1.86 A resolution To Be Published
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2AIR
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8SX3
| 10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10 | Descriptor: | 10E8 Fab heavy chain, 10E8 light chain, 10E8-GT10.2 immunogen, ... | Authors: | Huang, J, Ozorowski, G, Ward, A.B. | Deposit date: | 2023-05-19 | Release date: | 2024-05-22 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat.Immunol., 25, 2024
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1NMJ
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4O26
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8WA2
| cryo-EM structure of native mastigonemes isolated from Chlamydomonas reinhardtii at 3.0 angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huang, J, Tao, H, Chen, J, Pan, J, Yan, C, Yan, N. | Deposit date: | 2023-09-06 | Release date: | 2024-04-10 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure-guided discovery of protein and glycan components in native mastigonemes. Cell, 187, 2024
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6NO1
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