3WSB
 
 | | The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole | | 分子名称: | Farnesyltransferase, putative, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, ... | | 著者 | Shang, N, Li, Q, Huang, C.H, Oldfield, E, Guo, R.T. | | 登録日 | 2014-03-05 | | 公開日 | 2015-04-01 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
To be Published
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3WCA
 | | The complex structure of TcSQS with ligand, FSPP | | 分子名称: | Farnesyltransferase, putative, MAGNESIUM ION, ... | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Oldfield, E, Guo, R.T. | | 登録日 | 2013-05-26 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WL8
 | | Crystal Structure of pOPH S172A with octanoic acid | | 分子名称: | CITRIC ACID, OCTANOIC ACID (CAPRYLIC ACID), Oxidized polyvinyl alcohol hydrolase | | 著者 | Yang, Y, Ko, T.P, Li, J.H, Liu, L, Huang, C.H, Chan, H.C, Ren, F.F, Jia, D.X, Wang, A.H.-J, Guo, R.T, Chen, J, Du, G.C. | | 登録日 | 2013-11-08 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural insights into enzymatic degradation of oxidized polyvinyl alcohol
Chembiochem, 15, 2014
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3WUB
 | | The wild type crystal structure of b-1,4-Xylanase (XynAS9) from Streptomyces sp. 9 | | 分子名称: | Endo-1,4-beta-xylanase A, ZINC ION | | 著者 | Chen, C.C, Han, X, Lv, P, Ko, T.P, Peng, W, Huang, C.H, Zheng, Y, Gao, J, Yang, Y.Y, Guo, R.T. | | 登録日 | 2014-04-23 | | 公開日 | 2014-10-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability.
J.Biotechnol., 189C, 2014
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3WCH
 | | The complex structure of HsSQS wtih ligand BPH1237 | | 分子名称: | Squalene synthase, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WJK
 | | Crystal structure of Octaprenyl Pyrophosphate synthase from Escherichia coli | | 分子名称: | Octaprenyl diphosphate synthase | | 著者 | Han, X, Chen, C.C, Kuo, C.J, Huang, C.H, Zheng, Y, Ko, T.P, Zhu, Z, Feng, X, Oldfield, E, Liang, P.H, Guo, R.T, Ma, Y.H. | | 登録日 | 2013-10-11 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.
Proteins, 83, 2015
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3WLF
 | | Crystal structure of (R)-carbonyl reductase from Candida Parapsilosis in complex with (R)-1-phenyl-1,2-ethanediol | | 分子名称: | (1R)-1-phenylethane-1,2-diol, (R)-specific carbonyl reductase, ZINC ION | | 著者 | Wang, S.S, Nie, Y, Xu, Y, Zhang, R.Z, Huang, C.H, Chan, H.C, Guo, R.T, Xiao, R. | | 登録日 | 2013-11-09 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase
Chem.Commun.(Camb.), 50, 2014
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3WGZ
 | | Crystal structure of meso-dapdh Q154L/T173I/R199M/P248S/H249N/N276S mutant with D-leucine of from Clostridium tetani E88 | | 分子名称: | D-LEUCINE, Meso-diaminopimelate dehydrogenase | | 著者 | Liu, W.D, Li, Z, Huang, C.H, Guo, R.T, Wu, Q.Q, Zhu, D.M. | | 登録日 | 2013-08-20 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Crystal structure of meso-dapdh Q154L/T173I/R199M/P248S/H249N/N276S mutant with D-leucine of from Clostridium tetani E88
to be published
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3WUG
 | | The mutant crystal structure of b-1,4-Xylanase (XynAS9_V43P/G44E) with xylobiose from Streptomyces sp. 9 | | 分子名称: | Endo-1,4-beta-xylanase A, ZINC ION, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose | | 著者 | Chen, C.C, Han, X, Lv, P, Ko, T.P, Peng, W, Huang, C.H, Zheng, Y, Gao, J, Yang, Y.Y, Guo, R.T. | | 登録日 | 2014-04-23 | | 公開日 | 2014-10-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability.
J.Biotechnol., 189C, 2014
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3WWE
 | | The complex of pOPH with PEG | | 分子名称: | 2-(2-ETHOXYETHOXY)ETHANOL, Oxidized polyvinyl alcohol hydrolase | | 著者 | Yang, Y, Ko, T.P, Li, J.H, Liu, L, Huang, C.H, Chen, J, Guo, R.T, Du, G.C. | | 登録日 | 2014-06-17 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Roles of tryptophan residue and disulfide bond in the variable lid region of oxidized polyvinyl alcohol hydrolase
Biochem.Biophys.Res.Commun., 452, 2014
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3WCD
 | | The complex structure of HsSQS wtih ligand, WC-9 | | 分子名称: | 2-(4-phenoxyphenoxy)ethyl thiocyanate, Squalene synthase | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WDH
 | | Crystal structure of Pullulanase from Anoxybacillus sp. LM18-11 | | 分子名称: | CALCIUM ION, Type I pullulanase | | 著者 | Xu, J, Ren, F, Huang, C.H, Zheng, Y, Zhen, J, Ko, T.P, Chen, C.C, Chan, H.C, Guo, R.T, Ma, Y, Song, H. | | 登録日 | 2013-06-18 | | 公開日 | 2014-06-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Cloning, Expression, Functional and Structural Studies of Pullulanase from Anoxybacillus sp. LM18-11
To be Published
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3WLA
 | | Crystal Structure of sOPH Native | | 分子名称: | Oxidized polyvinyl alcohol hydrolase, SULFATE ION | | 著者 | Yang, Y, Ko, T.P, Li, J.H, Liu, L, Huang, C.H, Chan, H.C, Ren, F.F, Jia, D.X, Wang, A.H.-J, Guo, R.T, Chen, J, Du, G.C. | | 登録日 | 2013-11-08 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural insights into enzymatic degradation of oxidized polyvinyl alcohol
Chembiochem, 15, 2014
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3WCE
 | | The complex structure of TcSQS with ligand, ER119884 | | 分子名称: | (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Farnesyltransferase, putative | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WCM
 | | The complex structure of HsSQS wtih ligand, ER119884 | | 分子名称: | (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-28 | | 公開日 | 2014-06-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WQM
 | | Crystal structure of Rv3378c with inhibitor BPH-629 | | 分子名称: | Diterpene synthase, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Chan, H.C, Feng, X, Ko, T.P, Huang, C.H, Hu, Y, Zheng, Y, Bogue, S, Nakano, C, Hoshino, T, Zhang, L, Lv, P, Liu, W, Crick, D.C, Liang, P.H, Wang, A.H, Oldfield, E, Guo, R.T. | | 登録日 | 2014-01-28 | | 公開日 | 2014-02-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis.
J.Am.Chem.Soc., 136, 2014
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3WGO
 | | Crystal structure of Q154L/T173I/R199M/P248S/H249/N276S mutant of meso-dapdh from Clostridium tetani E88 | | 分子名称: | Meso-diaminopimelate dehydrogenase | | 著者 | Liu, W.D, Li, Z, Huang, C.H, Guo, R.T, Wu, Q.Q, Zhu, D.M. | | 登録日 | 2013-08-06 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structure of Q154L/T173I/R199M/P248S/H249 mutant of meso-dapdh from Clostridium tetani E88
To be Published
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3WC9
 | | The complex structure of HsSQS wtih ligand, FSPP | | 分子名称: | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-26 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WL7
 | | The complex structure of pOPH S172C with ligand, ACA | | 分子名称: | CITRIC ACID, Oxidized polyvinyl alcohol hydrolase, pentane-2,4-dione | | 著者 | Yang, Y, Ko, T.P, Li, J.H, Liu, L, Huang, C.H, Chan, H.C, Ren, F.F, Jia, D.X, Wang, A.H.-J, Guo, R.T, Chen, J, Du, G.C. | | 登録日 | 2013-11-08 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Structural insights into enzymatic degradation of oxidized polyvinyl alcohol
Chembiochem, 15, 2014
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3WLE
 | | Crystal structure of (R)-carbonyl reductase from Candida Parapsilosis in complex with NAD | | 分子名称: | (R)-specific carbonyl reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION | | 著者 | Wang, S.S, Nie, Y, Xu, Y, Zhang, R.Z, Huang, C.H, Chan, H.C, Guo, R.T, Xiao, R. | | 登録日 | 2013-11-08 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.164 Å) | | 主引用文献 | Unconserved substrate-binding sites direct the stereoselectivity of medium-chain alcohol dehydrogenase
Chem.Commun.(Camb.), 50, 2014
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3WCJ
 | | The complex structure of HsSQS wtih ligand,E5700 | | 分子名称: | (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WDI
 | | Crystal structure of Pullulanase complexed with maltotriose from Anoxybacillus sp. LM18-11 | | 分子名称: | CALCIUM ION, Type I pullulanase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Xu, J, Ren, F, Huang, C.H, Zheng, Y, Zhen, J, Ko, T.P, Chen, C.C, Chan, H.C, Guo, R.T, Ma, Y, Song, H. | | 登録日 | 2013-06-18 | | 公開日 | 2014-06-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Cloning, Expression, Functional and Structural Studies of Pullulanase from Anoxybacillus sp. LM18-11
To be Published
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3WCF
 | | The complex structure of HsSQS wtih ligand,BPH1218 | | 分子名称: | Squalene synthase, hydrogen [(1S)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | | 登録日 | 2013-05-27 | | 公開日 | 2014-06-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog., 10, 2014
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3WL6
 | | Crystal Structure of pOPH Native | | 分子名称: | CITRIC ACID, Oxidized polyvinyl alcohol hydrolase | | 著者 | Yang, Y, Ko, T.P, Li, J.H, Liu, L, Huang, C.H, Chan, H.C, Ren, F.F, Jia, D.X, Wang, A.H.-J, Guo, R.T, Chen, J, Du, G.C. | | 登録日 | 2013-11-08 | | 公開日 | 2014-09-24 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural insights into enzymatic degradation of oxidized polyvinyl alcohol
Chembiochem, 15, 2014
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3WUE
 | | The wild type crystal structure of b-1,4-Xylanase (XynAS9) with xylobiose from Streptomyces sp. 9 | | 分子名称: | Endo-1,4-beta-xylanase A, ZINC ION, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose | | 著者 | Chen, C.C, Han, X, Lv, P, Ko, T.P, Peng, W, Huang, C.H, Zheng, Y, Gao, J, Yang, Y, Guo, R.T. | | 登録日 | 2014-04-23 | | 公開日 | 2014-10-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural perspectives of an engineered beta-1,4-xylanase with enhanced thermostability.
J.Biotechnol., 189C, 2014
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