3WQM

Crystal structure of Rv3378c with inhibitor BPH-629

Summary for 3WQM

Entry DOI	10.2210/pdb3wqm/pdb
Related	3WQK 3WQL 3WQN
Descriptor	Diterpene synthase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	diterpene synthase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	35523.69
Authors	Chan, H.C.,Feng, X.,Ko, T.P.,Huang, C.H.,Hu, Y.,Zheng, Y.,Bogue, S.,Nakano, C.,Hoshino, T.,Zhang, L.,Lv, P.,Liu, W.,Crick, D.C.,Liang, P.H.,Wang, A.H.,Oldfield, E.,Guo, R.T. (deposition date: 2014-01-28, release date: 2014-02-26, Last modification date: 2023-11-08)
Primary citation	Chan, H.C.,Feng, X.,Ko, T.P.,Huang, C.H.,Hu, Y.,Zheng, Y.,Bogue, S.,Nakano, C.,Hoshino, T.,Zhang, L.,Lv, P.,Liu, W.,Crick, D.C.,Liang, P.H.,Wang, A.H.,Oldfield, E.,Guo, R.T. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. J.Am.Chem.Soc., 136:2892-2896, 2014 Cited by PubMed: 24475925 DOI: 10.1021/ja413127v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation