6X3W
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![BU of 6x3w by Molmil](/molmil-images/mine/6x3w) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, ... | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | Deposit date: | 2020-05-21 | Release date: | 2020-09-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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6X3U
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![BU of 6x3u by Molmil](/molmil-images/mine/6x3u) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | Deposit date: | 2020-05-21 | Release date: | 2020-09-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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6X3S
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![BU of 6x3s by Molmil](/molmil-images/mine/6x3s) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide | Descriptor: | (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | Deposit date: | 2020-05-21 | Release date: | 2020-09-09 | Last modified: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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6X40
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![BU of 6x40 by Molmil](/molmil-images/mine/6x40) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin | Descriptor: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | Deposit date: | 2020-05-21 | Release date: | 2020-09-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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8KCI
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![BU of 8kci by Molmil](/molmil-images/mine/8kci) | ATP-bound hMRP5 outward-open | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 5, MAGNESIUM ION | Authors: | Liu, Z.M, Huang, Y. | Deposit date: | 2023-08-07 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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6IRC
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![BU of 6irc by Molmil](/molmil-images/mine/6irc) | C-terminal domain of Drosophila phospholipase b NORPA, methylated | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | Authors: | Ye, F, Li, J, Huang, Y, Liu, W, Zhang, M. | Deposit date: | 2018-11-12 | Release date: | 2019-01-02 | Last modified: | 2020-10-28 | Method: | X-RAY DIFFRACTION (3.538 Å) | Cite: | An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife, 7, 2018
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6IRB
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![BU of 6irb by Molmil](/molmil-images/mine/6irb) | C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | Authors: | Ye, F, Li, J, Huang, Y, Liu, W, Zhang, M. | Deposit date: | 2018-11-12 | Release date: | 2019-01-02 | Last modified: | 2020-10-28 | Method: | X-RAY DIFFRACTION (2.661 Å) | Cite: | An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife, 7, 2018
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8FXF
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![BU of 8fxf by Molmil](/molmil-images/mine/8fxf) | Crystal structure of the coiled-coil domain of TRIM56 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase TRIM56 | Authors: | Lou, X.H, Ma, B.B, Zhuang, Y, Li, X.C. | Deposit date: | 2023-01-24 | Release date: | 2023-05-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions. Comput Struct Biotechnol J, 21, 2023
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5YVX
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![BU of 5yvx by Molmil](/molmil-images/mine/5yvx) | Crystal structure of SDG8 CW domain in complex with H3K4me1 peptide | Descriptor: | H3K4me1, Histone-lysine N-methyltransferase ASHH2, ZINC ION | Authors: | Liu, Y, Huang, Y. | Deposit date: | 2017-11-27 | Release date: | 2018-03-14 | Last modified: | 2018-05-09 | Method: | X-RAY DIFFRACTION (1.591 Å) | Cite: | Uncovering the mechanistic basis for specific recognition of monomethylated H3K4 by the CW domain ofArabidopsishistone methyltransferase SDG8. J. Biol. Chem., 293, 2018
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5XVW
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![BU of 5xvw by Molmil](/molmil-images/mine/5xvw) | |
5Y21
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![BU of 5y21 by Molmil](/molmil-images/mine/5y21) | |
5Y53
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![BU of 5y53 by Molmil](/molmil-images/mine/5y53) | |
8I0L
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![BU of 8i0l by Molmil](/molmil-images/mine/8i0l) | Structure of CDK9/cyclin T1 in complex with inhibitor | Descriptor: | 2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{N},~{N}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Cyclin-T1, Cyclin-dependent kinase 9 | Authors: | Jiang, C, Ye, Y, Huang, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure of CDK9/cyclin T1 in complex with inhibitor To Be Published
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5YTX
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![BU of 5ytx by Molmil](/molmil-images/mine/5ytx) | Crystal structure of YB1 cold-shock domain in complex with UCAACU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*AP*CP*U)-3') | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTT
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![BU of 5ytt by Molmil](/molmil-images/mine/5ytt) | Crystal structure of YB1 cold-shock domain in complex with UCAUGU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*GP*U)-3'), SULFATE ION | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTS
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![BU of 5yts by Molmil](/molmil-images/mine/5yts) | Crystal structure of YB1 cold-shock domain in complex with UCUUCU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*CP*UP*UP*C)-3'), SULFATE ION | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTV
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![BU of 5ytv by Molmil](/molmil-images/mine/5ytv) | Crystal structure of YB1 cold-shock domain in complex with UCAUCU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*CP*U)-3') | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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8I0M
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![BU of 8i0m by Molmil](/molmil-images/mine/8i0m) | Structure of CDK6 in complex with inhibitor | Descriptor: | 2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{N},~{N}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Cyclin-dependent kinase 6 | Authors: | Jiang, C, Ye, Y, Huang, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7772 Å) | Cite: | Structure of CDK6 in complex with inhibitor To Be Published
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5ZNL
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![BU of 5znl by Molmil](/molmil-images/mine/5znl) | Crystal structure of PDE10A catalytic domain complexed with LHB-6 | Descriptor: | MAGNESIUM ION, N-[2-(7-methoxy-4-morpholin-4-yl-quinazolin-6-yl)oxyethyl]-1,3-benzothiazol-2-amine, ZINC ION, ... | Authors: | Li, Z, Huang, Y, Zhan, C.G, Luo, H.B. | Deposit date: | 2018-04-09 | Release date: | 2019-02-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10. J. Med. Chem., 62, 2019
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5XVJ
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![BU of 5xvj by Molmil](/molmil-images/mine/5xvj) | Crystal structure of AL7 PAL domain | Descriptor: | PHD finger protein ALFIN-LIKE 7, SULFATE ION | Authors: | Peng, L, Wang, L.L, Huang, Y. | Deposit date: | 2017-06-28 | Release date: | 2018-07-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
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5XVL
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![BU of 5xvl by Molmil](/molmil-images/mine/5xvl) | Crystal structure of AL2 PAL domain | Descriptor: | PHD finger protein ALFIN-LIKE 2, SULFATE ION | Authors: | Peng, L, Wang, L.L, Huang, Y. | Deposit date: | 2017-06-28 | Release date: | 2018-07-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.629 Å) | Cite: | Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
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6A6J
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![BU of 6a6j by Molmil](/molmil-images/mine/6a6j) | Crystal structure of Zebra fish Y-box protein1 (YB-1) Cold-shock domain in complex with 6mer m5C RNA | Descriptor: | RNA (5'-R(P*CP*AP*UP*(5MC)P*U)-3'), ZINC ION, Zebra fish Y-box protein1 (YB-1) | Authors: | Zhang, M.M, Wu, B.X, Huang, Y, Ma, J.B. | Deposit date: | 2018-06-28 | Release date: | 2019-06-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.255 Å) | Cite: | RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol.Cell, 75, 2019
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7WZ6
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![BU of 7wz6 by Molmil](/molmil-images/mine/7wz6) | Crystal structure of MyoD-E47 | Descriptor: | Isoform E47 of Transcription factor E2-alpha, Myoblast determination protein 1 | Authors: | Zhong, J, Huang, Y, Ma, J. | Deposit date: | 2022-02-17 | Release date: | 2022-06-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis of the bHLH domains of MyoD-E47 heterodimer. Biochem.Biophys.Res.Commun., 621, 2022
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7F9Y
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![BU of 7f9y by Molmil](/molmil-images/mine/7f9y) | ghrelin-bound ghrelin receptor in complex with Gq | Descriptor: | CHOLESTEROL, Engineered G-alpha-q subunit, Ghrelin-28, ... | Authors: | Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. | Deposit date: | 2021-07-05 | Release date: | 2021-08-18 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
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7F9Z
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![BU of 7f9z by Molmil](/molmil-images/mine/7f9z) | GHRP-6-bound ghrelin receptor in complex with Gq | Descriptor: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. | Deposit date: | 2021-07-05 | Release date: | 2021-08-18 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
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