5ZNL
Crystal structure of PDE10A catalytic domain complexed with LHB-6
Summary for 5ZNL
| Entry DOI | 10.2210/pdb5znl/pdb |
| Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | pde10a inhibitor, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 75896.71 |
| Authors | Li, Z.,Huang, Y.,Zhan, C.G.,Luo, H.B. (deposition date: 2018-04-09, release date: 2019-02-20, Last modification date: 2023-11-22) |
| Primary citation | Li, Z.,Huang, Y.,Wu, Y.,Chen, J.,Wu, D.,Zhan, C.G.,Luo, H.B. Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10. J. Med. Chem., 62:2099-2111, 2019 Cited by PubMed: 30689375DOI: 10.1021/acs.jmedchem.8b01763 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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