5ZNL
Crystal structure of PDE10A catalytic domain complexed with LHB-6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 323 | 37421.1 | 2 | UniProt (Q9Y233) Pfam (PF00233) | Homo sapiens (Human) | |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | N-[2-(7-methoxy-4-morpholin-4-yl-quinazolin-6-yl)oxyethyl]-1,3-benzothiazol-2-amine | non-polymer | 437.5 | 2 | Chemie (9G6) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 770 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Met 448 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74842.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1054.5 | |
| All* | Total formula weight | 75896.7 |
