7RRY
 
 | | Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-20 | | 分子名称: | (1S,2R,4S,5S,6S)-5,6-bis(4-hydroxyphenyl)-N-{4-[3-(piperidin-1-yl)propoxy]phenyl}-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonamide, CHLORIDE ION, Estrogen receptor | | 著者 | Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W. | | 登録日 | 2021-08-10 | | 公開日 | 2021-09-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7RS7
 | | Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-30 | | 分子名称: | (1S,2R,4S,5S,6S)-N,5,6-tris(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonamide, Estrogen receptor | | 著者 | Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W. | | 登録日 | 2021-08-11 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6NBS
 | | WT ERK2 with compound 2507-8 | | 分子名称: | (5S)-5-benzyl-4,5-dihydro-1H-imidazol-2-amine, GLYCEROL, Mitogen-activated protein kinase 1, ... | | 著者 | Sammons, R.M, Perry, N.A, Cho, E.J, Kaoud, T.S, Zamora-Olivares, D.P, Piserchio, A, Houghten, R.A, Giulianotti, M, Li, Y, Debevec, G, Gurevich, V.V, Ghose, R, Iverson, T.M, Dalby, K.N. | | 登録日 | 2018-12-10 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.
Acs Chem.Biol., 14, 2019
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8BO2
 | | BAM-EspP complex structure with BamA-S425C/EspP-S1299C mutations in nanodisc | | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | | 著者 | Shen, C, Chang, S, Luo, Q, Zhang, Z, Xie, T, Luo, B, Lu, G, Zhu, X, Wei, X, Dong, C, Zhou, R, Zhang, X, Tang, X, Dong, H. | | 登録日 | 2022-11-14 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of BAM-mediated outer membrane beta-barrel protein assembly.
Nature, 617, 2023
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8BNZ
 | | BAM-EspP complex structure with BamA-G431C/EspP-N1293C mutations in nanodisc | | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | | 著者 | Shen, C, Chang, S, Luo, Q, Zhang, Z, Xie, T, Luo, B, Lu, G, Zhu, X, Wei, X, Dong, C, Zhou, R, Zhang, X, Tang, X, Dong, H. | | 登録日 | 2022-11-14 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of BAM-mediated outer membrane beta-barrel protein assembly.
Nature, 617, 2023
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3NSQ
 | | Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron | | 分子名称: | 1,8-dihydroxyanthracene-9,10-dione, Retinoid X receptor, alpha | | 著者 | Zhang, H, Hu, T, Li, L, Zhou, R, Chen, L, Hu, L, Jiang, H, Shen, X. | | 登録日 | 2010-07-02 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
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3NSP
 | | Crystal structure of tetrameric RXRalpha-LBD | | 分子名称: | Retinoid X receptor, alpha | | 著者 | Zhang, H, Hu, T, Li, L, Zhou, R, Chen, L, Hu, L, Jiang, H, Shen, X. | | 登録日 | 2010-07-02 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
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4EGO
 | | The X-ray crystal structure of CYP199A4 in complex with indole-6-carboxylic acid | | 分子名称: | 1H-indole-6-carboxylic acid, CHLORIDE ION, Cytochrome P450, ... | | 著者 | Zhou, W, Bell, S.G, Yang, W, Zhou, R.M, Tan, A.B.H, Wong, L.-L. | | 登録日 | 2012-03-31 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering
Chemistry, 18, 2012
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4EGP
 | | The X-ray crystal structure of CYP199A4 in complex with 2-naphthoic acid | | 分子名称: | CHLORIDE ION, Cytochrome P450, GLYCEROL, ... | | 著者 | Zhou, W, Bell, S.G, Yang, W, Zhou, R.M, Tan, A.B.H, Wong, L.-L. | | 登録日 | 2012-03-31 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering
Chemistry, 18, 2012
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4DNZ
 | | The crystal structures of CYP199A4 | | 分子名称: | CHLORIDE ION, Cytochrome P450, GLYCEROL, ... | | 著者 | Zhou, W, Bell, S.G, Yang, W, Tan, A.B.H, Zhou, R, Johnson, E.O.D, Zhang, A, Rao, Z, Wong, L.-L. | | 登録日 | 2012-02-09 | | 公開日 | 2012-08-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Dalton Trans, 41, 2012
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6IDF
 | | Cryo-EM structure of gamma secretase in complex with a Notch fragment | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y. | | 登録日 | 2018-09-09 | | 公開日 | 2018-12-26 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis of Notch recognition by human gamma-secretase
Nature, 565, 2019
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4EGM
 | | The X-ray crystal structure of CYP199A4 in complex with 4-ethylbenzoic acid | | 分子名称: | 4-ethylbenzoic acid, CHLORIDE ION, Cytochrome P450, ... | | 著者 | Zhou, W, Bell, S.G, Yang, W, Zhou, R.M, Tan, A.B.H, Wong, L.-L. | | 登録日 | 2012-03-31 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering
Chemistry, 18, 2012
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7RRZ
 | | Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-30 | | 分子名称: | (1S,2R,4S,5R,6S)-5-(4-hydroxyphenyl)-N-(4-methoxyphenyl)-6-{4-[3-(piperidin-1-yl)propoxy]phenyl}-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]heptane-2-sulfonamide, Estrogen receptor | | 著者 | Min, J, Nwachukwu, J.C, Min, C.K, Njeri, J.W, Srinivasan, S, Rangarajan, E.S, Nettles, C.C, Yan, S, Houtman, R, Griffin, P.R, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W. | | 登録日 | 2021-08-10 | | 公開日 | 2021-09-08 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Dual-mechanism estrogen receptor inhibitors.
Proc.Natl.Acad.Sci.USA, 118, 2021
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4DNJ
 | | The crystal structures of 4-methoxybenzoate bound CYP199A2 | | 分子名称: | 4-METHOXYBENZOIC ACID, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Zhou, W, Bell, S.G, Yang, W, Tan, A.B.H, Zhou, R, Johnson, E.O.D, Zhang, A, Rao, Z, Wong, L.-L. | | 登録日 | 2012-02-08 | | 公開日 | 2012-08-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Dalton Trans, 41, 2012
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4DO1
 | | The crystal structures of 4-methoxybenzoate bound CYP199A4 | | 分子名称: | 4-METHOXYBENZOIC ACID, CHLORIDE ION, Cytochrome P450, ... | | 著者 | Zhou, W, Bell, S.G, Yang, W, Tan, A.B.H, Zhou, R, Johnson, E.O.D, Zhang, A, Rao, Z, Wong, L.-L. | | 登録日 | 2012-02-09 | | 公開日 | 2012-08-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site
Dalton Trans, 41, 2012
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4EGN
 | | The X-ray crystal structure of CYP199A4 in complex with veratric acid | | 分子名称: | 3,4-dimethoxybenzoic acid, CHLORIDE ION, Cytochrome P450, ... | | 著者 | Zhou, W, Bell, S.G, Yang, W, Zhou, R.M, Tan, A.B.H, Wong, L.-L. | | 登録日 | 2012-03-31 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering
Chemistry, 18, 2012
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7BDX
 | | Armadillo domain of HSF2BP in complex with BRCA2 peptide | | 分子名称: | Breast cancer type 2 susceptibility protein, Heat shock factor 2-binding protein, MAGNESIUM ION | | 著者 | Le Du, M.H, Zinn-Justin, S, Ghouil, R, Miron, S, Legrand, P. | | 登録日 | 2020-12-22 | | 公開日 | 2021-07-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination.
Nat Commun, 12, 2021
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3MGH
 | | Binary complex of a DNA polymerase lambda loop mutant | | 分子名称: | DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3'), DNA (5'-D(P*GP*CP*CP*G)-3'), ... | | 著者 | Garcia-Diaz, M, Bebenek, K, Zhou, R.Z, Povirk, L.F, Kunkel, T. | | 登録日 | 2010-04-06 | | 公開日 | 2010-05-19 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Loop 1 modulates the fidelity of DNA polymerase lambda
Nucleic Acids Res., 38, 2010
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3MGI
 | | Ternary complex of a DNA polymerase lambda loop mutant | | 分子名称: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA, DNA (5'-D(*CP*AP*GP*TP*AP*T)-3'), ... | | 著者 | Garcia-Diaz, M, Bebenek, K, Zhou, R.Z, Povirk, L.F, Kunkel, T. | | 登録日 | 2010-04-06 | | 公開日 | 2010-05-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | | 主引用文献 | Loop 1 modulates the fidelity of DNA polymerase lambda
Nucleic Acids Res., 38, 2010
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5A63
 | | Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution. | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y. | | 登録日 | 2015-06-24 | | 公開日 | 2015-08-05 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | An Atomic Structure of Human Gamma-Secretase
Nature, 525, 2015
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5XMZ
 | | Verticillium effector PevD1 | | 分子名称: | CALCIUM ION, CHLORIDE ION, Effector protein PevD1 | | 著者 | Liu, X, Zhou, R. | | 登録日 | 2017-05-17 | | 公開日 | 2017-07-05 | | 最終更新日 | 2017-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The asparagine-rich protein NRP interacts with the Verticillium effector PevD1 and regulates the subcellular localization of cryptochrome 2
J. Exp. Bot., 68, 2017
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3M58
 | | SET7/9 Y245A in complex with TAF10-K189me1 peptide and AdoHcy | | 分子名称: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | | 著者 | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | | 登録日 | 2010-03-12 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
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3NJE
 | | Structure of the Minor Pseudopilin XcpW from the Pseudomonas aeruginosa Type II Secretion System | | 分子名称: | General secretion pathway protein J | | 著者 | Franz, L.P, Dyer, D.H, Voulhoux, R, Forest, K.T. | | 登録日 | 2010-06-17 | | 公開日 | 2011-02-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure of the minor pseudopilin XcpW from the Pseudomonas aeruginosa type II secretion system.
Acta Crystallogr.,Sect.D, 67, 2011
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3M53
 | | SET7/9 in complex with TAF10 peptide and AdoHcy | | 分子名称: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide | | 著者 | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | | 登録日 | 2010-03-12 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
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3M55
 | | SET7/9 Y305F in complex with TAF10-K189me1 peptide and AdoHcy | | 分子名称: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide | | 著者 | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | | 登録日 | 2010-03-12 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
J.Biol.Chem., 285, 2010
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