6ZDL
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![BU of 6zdl by Molmil](/molmil-images/mine/6zdl) | Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with GlcIFG and hexatungstotellurate(VI) TEW | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, 6-tungstotellurate(VI), ... | 著者 | Sobala, L.F, Fernandes, P.Z, Hakki, Z, Thompson, A.J, Howe, J.D, Hill, M, Zitzmann, N, Davies, S, Stamataki, Z, Butters, T.D, Alonzi, D.S, Williams, S.J, Davies, G.J. | 登録日 | 2020-06-14 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZJ1
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![BU of 6zj1 by Molmil](/molmil-images/mine/6zj1) | Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with tetrasaccharide N-glycan fragment and hexatungstotellurate(VI) TEW | 分子名称: | 6-tungstotellurate(VI), Glycoprotein endo-alpha-1,2-mannosidase, MAGNESIUM ION, ... | 著者 | Sobala, L.F, Fernandes, P.Z, Hakki, Z, Thompson, A.J, Howe, J.D, Hill, M, Zitzmann, N, Davies, S, Stamataki, Z, Butters, T.D, Alonzi, D.S, Williams, S.J, Davies, G.J. | 登録日 | 2020-06-27 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.957 Å) | 主引用文献 | Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZJ5
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![BU of 6zj5 by Molmil](/molmil-images/mine/6zj5) | Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with GlcDMJ and hexatungstotellurate(VI) TEW | 分子名称: | 1-DEOXYMANNOJIRIMYCIN, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 6-tungstotellurate(VI), ... | 著者 | Sobala, L.F, Fernandes, P.Z, Hakki, Z, Thompson, A.J, Howe, J.D, Hill, M, Zitzmann, N, Davies, S, Stamataki, Z, Butters, T.D, Alonzi, D.S, Williams, S.J, Davies, G.J. | 登録日 | 2020-06-27 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.269 Å) | 主引用文献 | Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZFN
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![BU of 6zfn by Molmil](/molmil-images/mine/6zfn) | Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with 1-methyl alpha-1,2-mannobiose | 分子名称: | Glycoprotein endo-alpha-1,2-mannosidase, SULFATE ION, alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside | 著者 | Sobala, L.F, Fernandes, P.Z, Hakki, Z, Thompson, A.J, Howe, J.D, Hill, M, Zitzmann, N, Davies, S, Stamataki, Z, Butters, T.D, Alonzi, D.S, Williams, S.J, Davies, G.J. | 登録日 | 2020-06-17 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proc.Natl.Acad.Sci.USA, 117, 2020
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3GZJ
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![BU of 3gzj by Molmil](/molmil-images/mine/3gzj) | Crystal Structure of Polyneuridine Aldehyde Esterase Complexed with 16-epi-Vellosimine | 分子名称: | 16-epi-Vellosimine, Polyneuridine-aldehyde esterase | 著者 | Yang, L, Hill, M, Wang, M, Panjikar, S, Stoeckigt, J. | 登録日 | 2009-04-07 | 公開日 | 2009-08-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids Angew.Chem.Int.Ed.Engl., 48, 2009
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2WFM
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![BU of 2wfm by Molmil](/molmil-images/mine/2wfm) | Crystal structure of polyneuridine aldehyde esterase mutant (H244A) | 分子名称: | POLYNEURIDINE ALDEHYDE ESTERASE | 著者 | Yang, L, Hill, M, Panjikar, S, Wang, M, Stoeckigt, J. | 登録日 | 2009-04-08 | 公開日 | 2010-04-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Basis and Enzymatic Mechanism of the Biosynthesis of C9- from C10-Monoterpenoid Indole Alkaloids. Angew.Chem.Int.Ed.Engl., 48, 2009
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4ZVT
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![BU of 4zvt by Molmil](/molmil-images/mine/4zvt) | |
2WFL
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![BU of 2wfl by Molmil](/molmil-images/mine/2wfl) | Crystal structure of polyneuridine aldehyde esterase | 分子名称: | POLYNEURIDINE-ALDEHYDE ESTERASE, SULFATE ION | 著者 | Yang, L, Hill, M, Panjikar, S, Wang, M, Stoeckigt, J. | 登録日 | 2009-04-08 | 公開日 | 2009-08-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis and Enzymatic Mechanism of the Biosynthesis of C9- from C10-Monoterpenoid Indole Alkaloids. Angew.Chem.Int.Ed.Engl., 48, 2009
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4ZVU
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![BU of 4zvu by Molmil](/molmil-images/mine/4zvu) | |
4ZVS
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![BU of 4zvs by Molmil](/molmil-images/mine/4zvs) | |
1QSM
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![BU of 1qsm by Molmil](/molmil-images/mine/1qsm) | Histone Acetyltransferase HPA2 from Saccharomyces Cerevisiae in Complex with Acetyl Coenzyme A | 分子名称: | ACETYL COENZYME *A, HPA2 HISTONE ACETYLTRANSFERASE | 著者 | Angus-Hill, M.L, Dutnall, R.N, Tafrov, S.T, Sternglanz, R, Ramakrishnan, V. | 登録日 | 1999-06-22 | 公開日 | 1999-12-22 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily. J.Mol.Biol., 294, 1999
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1DT1
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![BU of 1dt1 by Molmil](/molmil-images/mine/1dt1) | THERMUS THERMOPHILUS CYTOCHROME C552 SYNTHESIZED BY ESCHERICHIA COLI | 分子名称: | CYTOCHROME C552, HEME C | 著者 | Fee, J.A, Chen, Y, Hill, M.J, Gomez-Moran, E, Loehr, T, Ai, J, Thony-Meyer, L, Williams, P.A, Stura, E, Sridhar, V, McRee, D.E. | 登録日 | 2000-01-10 | 公開日 | 2000-02-18 | 最終更新日 | 2021-03-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Integrity of thermus thermophilus cytochrome c552 synthesized by Escherichia coli cells expressing the host-specific cytochrome c maturation genes, ccmABCDEFGH: biochemical, spectral, and structural characterization of the recombinant protein. Protein Sci., 9, 2000
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1QSO
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![BU of 1qso by Molmil](/molmil-images/mine/1qso) | Histone Acetyltransferase HPA2 from Saccharomyces Cerevisiae | 分子名称: | HPA2 HISTONE ACETYLTRANSFERASE | 著者 | Angus-Hill, M.L, Dutnall, R.N, Tafrov, S.T, Sterngalnz, R, Ramakrishnan, V. | 登録日 | 1999-06-22 | 公開日 | 1999-12-22 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily. J.Mol.Biol., 294, 1999
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1R0Q
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![BU of 1r0q by Molmil](/molmil-images/mine/1r0q) | Characterization of the conversion of the malformed, recombinant cytochrome rc552 to a 2-formyl-4-vinyl (Spirographis) heme | 分子名称: | 2-FORMYL-PROTOPORPHRYN IX, Cytochrome c-552 | 著者 | Fee, J.A, Todaro, T.R, Luna, E, Sanders, D, Hunsicker-Wang, L.M, Patel, K.M, Bren, K.L, Gomez-Moran, E, Hill, M.G, Ai, J, Loehr, T.M, Oertling, W.A, Williams, P.A, Stout, C.D, McRee, D, Pastuszyn, A. | 登録日 | 2003-09-22 | 公開日 | 2004-09-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Cytochrome rC552, formed during expression of the truncated, Thermus thermophilus cytochrome c552 gene in the cytoplasm of Escherichia coli, reacts spontaneously to form protein-bound 2-formyl-4-vinyl (Spirographis) heme. Biochemistry, 43, 2004
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1QYZ
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![BU of 1qyz by Molmil](/molmil-images/mine/1qyz) | Characterization of the malformed, recombinant cytochrome rC552 | 分子名称: | 2-ACETYL-PROTOPORPHYRIN IX, Cytochrome c-552 | 著者 | Fee, J.A, Todaro, T.R, Luna, E, Sanders, D, Hunsicker-Wang, L.M, Patel, K.M, Bren, K.L, Gomez-Moran, E, Hill, M.G, Ai, J, Loehr, T.M, Oertling, W.A, Williams, P.A, Stout, C.D, McRee, D, Pastuszyn, A. | 登録日 | 2003-09-12 | 公開日 | 2004-09-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Cytochrome rC552, formed during expression of the truncated, Thermus thermophilus cytochrome c552 gene in the cytoplasm of Escherichia coli, reacts spontaneously to form protein-bound 2-formyl-4-vinyl (Spirographis) heme. Biochemistry, 43, 2004
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3ZEV
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![BU of 3zev by Molmil](/molmil-images/mine/3zev) | Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion | 分子名称: | GLYCINE, NEUROTENSIN, NEUROTENSIN RECEPTOR 1 TM86V | 著者 | Egloff, P, Hillenbrand, M, Schlinkmann, K.M, Batyuk, A, Mittl, P, Plueckthun, A. | 登録日 | 2012-12-07 | 公開日 | 2014-01-29 | 最終更新日 | 2014-02-26 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli Proc.Natl.Acad.Sci.USA, 111, 2014
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6VTY
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4ID7
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![BU of 4id7 by Molmil](/molmil-images/mine/4id7) | ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol | 分子名称: | Activated CDC42 kinase 1, SULFATE ION, cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol | 著者 | Jin, M, Wang, J, Kleinberg, A, Kadalbajoo, M, Siu, K, Cooke, A, Bittner, M, Yao, Y, Thelemann, A, Ji, Q, Bhagwat, S, Crew, A.P, Pachter, J, Epstein, D, Mulvihill, M.J. | 登録日 | 2012-12-11 | 公開日 | 2013-01-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4IGH
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![BU of 4igh by Molmil](/molmil-images/mine/4igh) | High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog | 分子名称: | 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, 6-fluoro-2-[2-methyl-4-phenoxy-5-(propan-2-yl)phenyl]quinoline-4-carboxylic acid, Dihydroorotate dehydrogenase (quinone), ... | 著者 | Deng, X, Das, P, Fontoura, B.M.A, Phillips, M.A, De Brabander, J.K. | 登録日 | 2012-12-17 | 公開日 | 2013-08-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. ACS MED.CHEM.LETT., 4, 2013
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4RX0
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![BU of 4rx0 by Molmil](/molmil-images/mine/4rx0) | Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM265 | 分子名称: | 2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Deng, X, Phillips, M, Tomchick, D. | 登録日 | 2014-12-08 | 公開日 | 2015-07-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7, 2015
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1JI7
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![BU of 1ji7 by Molmil](/molmil-images/mine/1ji7) | Crystal Structure of TEL SAM Polymer | 分子名称: | ETS-RELATED PROTEIN TEL1, SULFATE ION | 著者 | Kim, C.A, Phillips, M.L, Kim, W, Gingery, M, Tran, H.H, Robinson, M.A, Faham, S, Bowie, J.U. | 登録日 | 2001-06-29 | 公開日 | 2002-07-03 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression. EMBO J., 20, 2001
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6VZ6
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![BU of 6vz6 by Molmil](/molmil-images/mine/6vz6) | Methanococcoides burtonii cytochrome b5 domain protein (WP 011499504.1) | 分子名称: | Cytochrome b5-domain protein, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Teakel, S.L, Forwood, J.K, Aragao, D, Cahill, M.A, Marama, M. | 登録日 | 2020-02-27 | 公開日 | 2020-03-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Methanococcoides burtonii cytochrome b5 domain protein (WP 011499504.1) To Be Published
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1SZR
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![BU of 1szr by Molmil](/molmil-images/mine/1szr) | A Dimer interface mutant of ornithine decarboxylase reveals structure of gem diamine intermediate | 分子名称: | N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-D-ORNITHINE, Ornithine decarboxylase, ... | 著者 | Jackson, L.K, Baldwin, J, Goldsmith, E.J, Phillips, M.A. | 登録日 | 2004-04-06 | 公開日 | 2004-10-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase Biochemistry, 43, 2004
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1SSU
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![BU of 1ssu by Molmil](/molmil-images/mine/1ssu) | Structural and biochemical evidence for disulfide bond heterogeneity in active forms of the somatomedin B domain of human vitronectin | 分子名称: | Vitronectin | 著者 | Kamikubo, Y, De Guzman, R, Kroon, G, Curriden, S, Neels, J.G, Churchill, M.J, Dawson, P, Oldziej, S, Jagielska, A, Scheraga, H.A, Loskutoff, D.J, Dyson, H.J. | 登録日 | 2004-03-24 | 公開日 | 2004-07-27 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin. Biochemistry, 43, 2004
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4UNT
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![BU of 4unt by Molmil](/molmil-images/mine/4unt) | Induced monomer of the Mcg variable domain | 分子名称: | IG LAMBDA CHAIN V-II REGION MGC, SULFATE ION | 著者 | Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C.M, Whitelegge, J.P, Phillips, M.L, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2014-05-30 | 公開日 | 2014-08-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains. J.Biol.Chem., 289, 2014
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