4C25
 
 | | L-fuculose 1-phosphate aldolase | | Descriptor: | 1,2-ETHANEDIOL, 1,3-DIHYDROXYACETONEPHOSPHATE, GLYCEROL, ... | | Authors: | Higgins, M.A, Suits, M.D.L, Marsters, C, Boraston, A.B. | | Deposit date: | 2013-08-16 | | Release date: | 2013-12-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus Pneumoniae.
J.Mol.Biol., 426, 2014
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4C22
 | | L-Fucose Isomerase In Complex With Fuculose | | Descriptor: | 1,2-ETHANEDIOL, L-FUCOSE ISOMERASE, L-Fuculose open form, ... | | Authors: | Higgins, M.A, Suits, M.D.L, Marsters, C, Boraston, A.B. | | Deposit date: | 2013-08-16 | | Release date: | 2013-12-11 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus Pneumoniae.
J.Mol.Biol., 426, 2014
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2YGM
 | | THE X-RAY CRYSTAL STRUCTURE OF TANDEM CBM51 MODULES OF SP3GH98, THE FAMILY 98 GLYCOSIDE HYDROLASE FROM STREPTOCOCCUS PNEUMONIAE SP3-BS71, IN COMPLEX WITH THE BLOOD GROUP B ANTIGEN | | Descriptor: | BLOOD GROUP A-AND B-CLEAVING ENDO-BETA-GALACTOSIDASE, CALCIUM ION, SODIUM ION, ... | | Authors: | Higgins, M.A, Ficko-Blean, E, Wright, C, Meloncelli, P.J, Lowary, T.L, Boraston, A.B. | | Deposit date: | 2011-04-19 | | Release date: | 2011-06-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate Antigen Hydrolyzing Enzymes.
J.Mol.Biol., 411, 2011
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4A34
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2YGL
 | | The X-ray crystal structure of tandem CBM51 modules of Sp3GH98, the family 98 glycoside hydrolase from Streptococcus pneumoniae SP3-BS71 | | Descriptor: | BLOOD GROUP A-AND B-CLEAVING ENDO-BETA-GALACTOSIDASE, CALCIUM ION | | Authors: | Higgins, M.A, Ficko-Blean, E, Wright, C, Meloncelli, P.J, Lowary, T.L, Boraston, A.B. | | Deposit date: | 2011-04-18 | | Release date: | 2011-06-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate Antigen Hydrolyzing Enzymes.
J.Mol.Biol., 411, 2011
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8A44
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4V3E
 | | The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ... | | Authors: | Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K. | | Deposit date: | 2014-10-17 | | Release date: | 2014-12-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
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8OVB
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2WAU
 | | Structure of DBL6 epsilon domain from VAR2CSA | | Descriptor: | ERYTHROCYTE MEMBRANE PROTEIN 1 (PFEMP1) | | Authors: | Khunrae, P, Higgins, M.K. | | Deposit date: | 2009-02-16 | | Release date: | 2009-08-18 | | Last modified: | 2014-12-03 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Comparison of Two Cspg-Binding Dbl Domains from the Var2Csa Protein Important in Malaria During Pregnancy.
J.Mol.Biol., 393, 2009
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6XZ6
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6H5N
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4X0L
 | | Human haptoglobin-haemoglobin complex | | Descriptor: | CACODYLATE ION, GLYCEROL, Haptoglobin, ... | | Authors: | Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K. | | Deposit date: | 2014-11-21 | | Release date: | 2014-12-24 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
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4X0J
 | | Trypanosoma brucei haptoglobin-haemoglobin receptor | | Descriptor: | Haptoglobin-hemoglobin receptor | | Authors: | Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K. | | Deposit date: | 2014-11-21 | | Release date: | 2014-12-24 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
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7PI3
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5JDO
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7PHV
 | | PfCyRPA bound to monoclonal antibody Cy.007 Fab fragment | | Descriptor: | AMMONIUM ION, Cysteine-rich protective antigen, Monoclonal antibody Cy.007 heavy chain, ... | | Authors: | Ragotte, R.J, Higgins, M.K. | | Deposit date: | 2021-08-18 | | Release date: | 2022-02-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.091 Å) | | Cite: | Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun, 13, 2022
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5HU6
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8CDE
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8CDD
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7ZWM
 | | Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.69 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWI
 | | Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 32F3 heavy chain, 32F3 light chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZXG
 | | Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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6P29
 | | N-demethylindolmycin synthase (PluN2) in complex with N-demethylindolmycin | | Descriptor: | (5S)-2-amino-5-[(1R)-1-(1H-indol-3-yl)ethyl]-1,3-oxazol-4(5H)-one, N-demethylindolmycin synthase (PluN2), TRIETHYLENE GLYCOL | | Authors: | Du, Y.L, Higgins, M.A, Zhao, G, Ryan, K.S. | | Deposit date: | 2019-05-21 | | Release date: | 2019-08-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Convergent biosynthetic transformations to a bacterial specialized metabolite.
Nat.Chem.Biol., 15, 2019
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7ZXF
 | | Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1 | | Descriptor: | 10D8 heavy chain, 10D8 light chain, 85RF45.1 heavy chain, ... | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-20 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.72 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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7ZWF
 | | Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3 | | Descriptor: | 32F3scFv, Gametocyte surface protein P45/48, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Ko, K.T, Lennartz, F.L, Higgins, M.K. | | Deposit date: | 2022-05-19 | | Release date: | 2022-06-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.132 Å) | | Cite: | Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
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