4OG8
 
 | | Human menin with bound inhibitor MIV-6R | | 分子名称: | 2-PHOSPHOGLYCOLIC ACID, 4-(3-{4-[(R)-amino(cyclopentyl)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile, DIMETHYL SULFOXIDE, ... | | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57, 2014
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4OG5
 | | Human menin with bound inhibitor MIV-5 | | 分子名称: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57, 2014
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4OG4
 | | Human menin with bound inhibitor MIV-3S | | 分子名称: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57, 2014
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4OG3
 | | Human menin with bound inhibitor MIV-3R | | 分子名称: | 4-(3-{4-[(R)-cyclopentyl(hydroxy)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57, 2014
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6LTH
 | | Structure of human BAF Base module | | 分子名称: | AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ... | | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | | 登録日 | 2020-01-22 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
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6LTJ
 | | Structure of nucleosome-bound human BAF complex | | 分子名称: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | | 登録日 | 2020-01-22 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
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6NSN
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6NSM
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6NSR
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4OG6
 | | Human menin with bound inhibitor MIV-4 | | 分子名称: | 4-(3-{4-[(R)-cyclopentyl(3-fluorophenyl)hydroxymethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57, 2014
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4OG7
 | | Human menin with bound inhibitor MIV-7 | | 分子名称: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | | 登録日 | 2014-01-15 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57, 2014
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6KLB
 | | Structure of LbCas12a-crRNA complex bound to AcrVA4 (form B complex) | | 分子名称: | AcrVA4, LbCas12a, MAGNESIUM ION, ... | | 著者 | Peng, R, Li, Z, Xu, Y, He, S, Peng, Q, Shi, Y, Gao, G.F. | | 登録日 | 2019-07-30 | | 公開日 | 2019-09-11 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7Y8R
 | | The nucleosome-bound human PBAF complex | | 分子名称: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | | 著者 | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | | 登録日 | 2022-06-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structure of nucleosome-bound human PBAF complex.
Nat Commun, 13, 2022
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1B3E
 | | HUMAN SERUM TRANSFERRIN, N-TERMINAL LOBE, EXPRESSED IN PICHIA PASTORIS | | 分子名称: | CARBONATE ION, FE (III) ION, PROTEIN (SERUM TRANSFERRIN) | | 著者 | Bewley, M.C, Tam, B.M, Grewal, J, He, S, Shewry, S, Murphy, M.E.P, Mason, A.B, Woodworth, R.C, Baker, E.N, Macgillivray, R.T.A. | | 登録日 | 1998-12-09 | | 公開日 | 1999-03-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32.
Biochemistry, 38, 1999
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6SRI
 | | Structure of the Fanconi anaemia core complex | | 分子名称: | Fanconi anaemia protein FANCL, Unassigned secondary structure elements (base region, proposed FANCC-FANC-E-FANCF), ... | | 著者 | Shakeel, S, Rajendra, E, Alcon, P, He, S, Scheres, S.H.W, Passmore, L.A. | | 登録日 | 2019-09-05 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature, 575, 2019
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6SRS
 | | Structure of the Fanconi anaemia core subcomplex | | 分子名称: | Fanconi anaemia protein FANCL, Unassigned secondary structure elements (central region, proposed FANCB-FAAP100), ... | | 著者 | Shakeel, S, Rajendra, E, Alcon, P, He, S, Scheres, S.H.W, Passmore, L.A. | | 登録日 | 2019-09-05 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature, 575, 2019
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4U7P
 | | Crystal structure of DNMT3A-DNMT3L complex | | 分子名称: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Wang, L, Guo, X, Li, J, Xiao, J, Yin, X, He, S, Wang, J, Xu, Y. | | 登録日 | 2014-07-31 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.821 Å) | | 主引用文献 | Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015
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4U7T
 | | Crystal structure of DNMT3A-DNMT3L in complex with histone H3 | | 分子名称: | DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Guo, X, Wang, L, Yin, X, Li, J, Xiao, J, He, S, Wang, J, Xu, Y. | | 登録日 | 2014-07-31 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Nature, 517, 2015
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7JFO
 | | EPYC1(49-72)-bound Rubisco | | 分子名称: | LCI5, Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 2, ... | | 著者 | Matthies, D, Jonikas, M.C, He, S. | | 登録日 | 2020-07-17 | | 公開日 | 2020-11-18 | | 最終更新日 | 2020-12-23 | | 実験手法 | ELECTRON MICROSCOPY (2.13 Å) | | 主引用文献 | The structural basis of Rubisco phase separation in the pyrenoid.
Nat.Plants, 6, 2020
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5N8N
 | | Contracted sheath of a Pseudomonas aeruginosa type six secretion system consisting of TssB1 and TssC1 | | 分子名称: | EvpB family type VI secretion protein, Type VI secretion protein, family | | 著者 | Salih, O, He, S, Stach, L, Macdonald, J.T, Planamente, S, Manoli, E, Scheres, S, Filloux, A, Freemont, P.S. | | 登録日 | 2017-02-23 | | 公開日 | 2018-01-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.
Structure, 26, 2018
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7JN4
 | | Rubisco in the apo state | | 分子名称: | Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 2, chloroplastic | | 著者 | Matthies, D, Jonikas, M.C, He, S. | | 登録日 | 2020-08-03 | | 公開日 | 2020-11-18 | | 最終更新日 | 2020-12-23 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | The structural basis of Rubisco phase separation in the pyrenoid.
Nat.Plants, 6, 2020
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7JSX
 | | EPYC1(106-135) peptide-bound Rubisco | | 分子名称: | EPYC1, Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 2, ... | | 著者 | Matthies, D, He, S, Jonikas, M.C. | | 登録日 | 2020-08-16 | | 公開日 | 2020-11-18 | | 最終更新日 | 2020-12-23 | | 実験手法 | ELECTRON MICROSCOPY (2.06 Å) | | 主引用文献 | The structural basis of Rubisco phase separation in the pyrenoid.
Nat.Plants, 6, 2020
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6RZA
 | | Cryo-EM structure of the human inner arm dynein DNAH7 microtubule binding domain bound to microtubules | | 分子名称: | Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain 7, axonemal,Cytoplasmic dynein 1 heavy chain 1, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Lacey, S.E, He, S, Scheres, S.H.W, Carter, A.P. | | 登録日 | 2019-06-13 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule.
Elife, 8, 2019
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6RZB
 | | Cryo-EM structure of mouse cytoplasmic dynein-1 microtubule binding domain bound to microtubules | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Lacey, S.E, He, S, Scheres, S.H.W, Carter, A.P. | | 登録日 | 2019-06-13 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule.
Elife, 8, 2019
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5O3T
 | | Straight filament in Alzheimer's disease brain | | 分子名称: | Microtubule-associated protein tau | | 著者 | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | | 登録日 | 2017-05-24 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature, 547, 2017
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