4OG3
Human menin with bound inhibitor MIV-3R
Summary for 4OG3
Entry DOI | 10.2210/pdb4og3/pdb |
Related | 4OG4 4OG5 4OG6 4OG7 4OG8 |
Descriptor | Menin, SULFATE ION, 4-(3-{4-[(R)-cyclopentyl(hydroxy)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile, ... (7 entities in total) |
Functional Keywords | protein binding, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O00255 |
Total number of polymer chains | 1 |
Total formula weight | 55000.00 |
Authors | He, S.,Senter, T.J.,Pollock, J.W.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J. (deposition date: 2014-01-15, release date: 2014-03-05, Last modification date: 2024-02-28) |
Primary citation | He, S.,Senter, T.J.,Pollock, J.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J. High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57:1543-1556, 2014 Cited by PubMed: 24472025DOI: 10.1021/jm401868d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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