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4OG5

Human menin with bound inhibitor MIV-5

Summary for 4OG5
Entry DOI10.2210/pdb4og5/pdb
Related4OG3 4OG4 4OG6 4OG7 4OG8
DescriptorMenin, 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzonitrile, SULFATE ION, ... (8 entities in total)
Functional Keywordsprotein binding-inhibitor complex, protein binding/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O00255
Total number of polymer chains1
Total formula weight55014.93
Authors
He, S.,Senter, T.J.,Pollock, J.W.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J. (deposition date: 2014-01-15, release date: 2014-03-05, Last modification date: 2023-09-20)
Primary citationHe, S.,Senter, T.J.,Pollock, J.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J.
High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.
J.Med.Chem., 57:1543-1556, 2014
Cited by
PubMed: 24472025
DOI: 10.1021/jm401868d
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.63 Å)
Structure validation

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