7EJC
| human RAD51 presynaptic complex | 分子名称: | 4-bromanyl-N-(4-bromophenyl)-3-[(phenylmethyl)sulfamoyl]benzamide, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, ... | 著者 | Zhao, L.Y, Xu, J.F, Wang, H.W. | 登録日 | 2021-04-02 | 公開日 | 2022-04-06 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. Nucleic Acids Res., 49, 2021
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7EJE
| human RAD51 post-synaptic complex | 分子名称: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA repair protein RAD51 homolog 1, ... | 著者 | Zhao, L.Y, Xu, J.F, Wang, H.W. | 登録日 | 2021-04-02 | 公開日 | 2022-03-16 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. Nucleic Acids Res., 49, 2021
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7EJ6
| Yeast Dmc1 presynaptic complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), HLJ1_G0016300.mRNA.1.CDS.1, ... | 著者 | Zhao, L.Y, Xu, J.F, Wang, H.W. | 登録日 | 2021-04-01 | 公開日 | 2022-04-20 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. Nucleic Acids Res., 49, 2021
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7EJ7
| Yeast Dmc1 post-synaptic complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | 著者 | Zhao, L.Y, Xu, J.F, Wang, H.W. | 登録日 | 2021-04-01 | 公開日 | 2022-04-20 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. Nucleic Acids Res., 49, 2021
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3SOA
| Full-length human CaMKII | 分子名称: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker | 著者 | Chao, L.H, Kuriyan, J. | 登録日 | 2011-06-30 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.5501 Å) | 主引用文献 | A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme. Cell(Cambridge,Mass.), 146, 2011
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8ITM
| Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein | 分子名称: | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, F.H, Hang, K.N, Zhou, Q.T, Shao, L.J, Li, H, Li, W.Z, Lin, S, Dai, A.T, Cai, X.Q, Liu, Y.Y, Xu, Y.N, Feng, W.B, Yang, D.H, Wang, M.W. | 登録日 | 2023-03-22 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Molecular basis of signal transduction mediated by the human GIPR splice variants. Proc.Natl.Acad.Sci.USA, 120, 2023
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8ITL
| Cryo-EM structure of GIPR splice variant 1 (SV1) in complex with Gs protein | 分子名称: | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, F.H, Hang, K.N, Zhou, Q.T, Shao, L.J, Li, H, Li, W.Z, Lin, S, Dai, A.T, Cai, X.Q, Liu, Y.Y, Xu, Y.N, Feng, W.B, Yang, D.H, Wang, M.W. | 登録日 | 2023-03-22 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Molecular basis of signal transduction mediated by the human GIPR splice variants. Proc.Natl.Acad.Sci.USA, 120, 2023
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3CFU
| Crystal structure of the yjhA protein from Bacillus subtilis. Northeast Structural Genomics Consortium target SR562 | 分子名称: | Uncharacterized lipoprotein yjhA | 著者 | Vorobiev, S.M, Chen, Y, Kuzin, A.P, Seetharaman, J, Forouhar, F, Zhao, L, Mao, L, Maglaqui, M, Xiao, R, Liu, J, Swapna, G, Huang, J.Y, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-03-04 | 公開日 | 2008-03-18 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the yjhA protein from Bacillus subtilis. To be Published
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3KL8
| CaMKIINtide Inhibitor Complex | 分子名称: | Calcium/calmodulin dependent protein kinase II, Calcium/calmodulin-dependent protein kinase II inhibitor 1 | 著者 | Kuriyan, J, Chao, L.H, Pellicena, P, Deindl, S, Barclay, L.A, Schulman, H. | 登録日 | 2009-11-06 | 公開日 | 2010-02-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.372 Å) | 主引用文献 | Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat.Struct.Mol.Biol., 17, 2010
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4DLH
| Crystal Structure of the protein Q9HRE7 from Halobacterium salinarium at the resolution 1.9A, Northeast Structural Genomics Consortium (NESG) Target HsR50 | 分子名称: | uncharacterized protein | 著者 | Kuzin, A, Chen, Y, Seetharaman, J, Mao, M, Xiao, R, Ciccosanti, C, Zhao, L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-02-06 | 公開日 | 2012-02-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target HsR50 To be Published
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2F4J
| Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680 | 分子名称: | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, Proto-oncogene tyrosine-protein kinase ABL1 | 著者 | Young, M.A, Shah, N.P, Chao, L.H, Zarrinkar, P, Sawyers, P, Kuriyan, J. | 登録日 | 2005-11-23 | 公開日 | 2006-01-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res., 66, 2006
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7V9M
| Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Chen, X, Yang, D.H, Wang, M.W. | 登録日 | 2021-08-26 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7V9L
| Cryo-EM structure of the SV1-Gs complex. | 分子名称: | GHRH receptor splice variant 1,GHRH receptor splice variant 1,GHRH receptor splice variant 1,SV1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Cheng, X, Yang, D.H, Wang, M.W. | 登録日 | 2021-08-26 | 公開日 | 2022-04-06 | 最終更新日 | 2022-05-04 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021
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8YW5
| Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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8YW3
| Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-09-18 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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8YW4
| Cryo-EM structure of the retatrutide-bound human GIPR-Gs complex | 分子名称: | Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-09-18 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
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7X3O
| Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07054 | 分子名称: | (2~{R})-2-(3-fluoranyl-4-pyrimidin-5-yl-phenyl)butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07054 To Be Published
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7X3L
| Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044 | 分子名称: | (2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem., 66, 2023
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7X3M
| Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07045 | 分子名称: | (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.694 Å) | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem., 66, 2023
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9IY0
| anti-HEV mAb 8H3 | 分子名称: | Heavy chain of 8H3 Fab, Light chain of 8H3 Fab, MAGNESIUM ION | 著者 | Minghua, Z, Lizhi, Z, Yang, H, Ying, G, Shaowei, L. | 登録日 | 2024-07-29 | 公開日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural basis for the synergetic neutralization of hepatitis E virus by antibody-antibody interaction To Be Published
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4UIS
| The cryoEM structure of human gamma-Secretase complex | 分子名称: | GAMMA-SECRETASE, LYSOZYME | 著者 | Sun, L, Zhao, L, Yang, G, Yan, C, Zhou, R, Zhou, X, Xie, T, Zhao, Y, Wu, S, Li, X, Shi, Y. | 登録日 | 2015-04-03 | 公開日 | 2015-06-10 | 最終更新日 | 2017-08-02 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural Basis of Human Gamma-Secretase Assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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9IY2
| Immune complex of HEV-E2s, nAb 8C11 and nAb 8H3 | 分子名称: | Heavy Chain of mAb 8C11, Heavy Chain of mAb 8H3, Light Chain of mAb 8C11, ... | 著者 | Minghua, Z, Lizhi, Z, Ying, G, Shaowei, L. | 登録日 | 2024-07-29 | 公開日 | 2024-08-28 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (3.476 Å) | 主引用文献 | Structural basis for the synergetic neutralization of hepatitis E virus by antibody-antibody interaction To Be Published
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3U3Q
| The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6) | 分子名称: | Tumor necrosis factor receptor superfamily member 21 | 著者 | Ru, H, Zhao, L.X, Ding, W, Jiao, L.Y, Shaw, N, Zhang, L.G, Hung, L.W, Matsugaki, N, Wakatsuki, S, Liu, Z.J. | 登録日 | 2011-10-06 | 公開日 | 2012-05-02 | 最終更新日 | 2013-07-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr.,Sect.D, 68, 2012
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3U3P
| The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6) | 分子名称: | Tumor necrosis factor receptor superfamily member 21 | 著者 | Ru, H, Zhao, L.X, Ding, W, Jiao, L.Y, Shaw, N, Zhang, L.G, Hung, L.W, Matsugaki, N, Wakatsuki, S, Liu, Z.J. | 登録日 | 2011-10-06 | 公開日 | 2012-05-02 | 最終更新日 | 2013-07-10 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS Acta Crystallogr.,Sect.D, 68, 2012
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3U3S
| The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6) | 分子名称: | Tumor necrosis factor receptor superfamily member 21 | 著者 | Ru, H, Zhao, L.X, Ding, W, Jiao, L.Y, Shaw, N, Zhang, L.G, Hung, L.W, Matsugaki, N, Wakatsuki, S, Liu, Z.J. | 登録日 | 2011-10-06 | 公開日 | 2012-05-02 | 最終更新日 | 2013-07-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr.,Sect.D, 68, 2012
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