2M74
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![BU of 2m74 by Molmil](/molmil-images/mine/2m74) | 1H, 13C and 15N assignments of the four N-terminal domains of human fibrillin-1 | Descriptor: | Fibrillin-1 | Authors: | Yadin, D.A, Robertson, I.B, Jensen, S.A, Handford, P.A, Redfield, C. | Deposit date: | 2013-04-17 | Release date: | 2013-09-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly. Structure, 21, 2013
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2W86
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![BU of 2w86 by Molmil](/molmil-images/mine/2w86) | Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form | Descriptor: | CALCIUM ION, FIBRILLIN-1, IODIDE ION | Authors: | Jensen, S.A, Iqbal, S, Lowe, E.D, Redfield, C, Handford, P.A. | Deposit date: | 2009-01-09 | Release date: | 2009-05-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/Ltbp Superfamily of Matrix Proteins. Structure, 17, 2009
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2VJ2
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![BU of 2vj2 by Molmil](/molmil-images/mine/2vj2) | Human Jagged-1, domains DSL and EGFs1-3 | Descriptor: | D-MALATE, JAGGED-1 | Authors: | Johnson, S, Cordle, J, Tay, J.Z, Roversi, P, Handford, P.A, Lea, S.M. | Deposit date: | 2007-12-06 | Release date: | 2008-07-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition. Nat.Struct.Mol.Biol., 15, 2008
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5FMA
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![BU of 5fma by Molmil](/molmil-images/mine/5fma) | human Notch 1, EGF 4-7 | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C. | Deposit date: | 2015-11-02 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24, 2016
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5FM9
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![BU of 5fm9 by Molmil](/molmil-images/mine/5fm9) | human Notch 1, EGF 4-7 | Descriptor: | CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 | Authors: | Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C. | Deposit date: | 2015-11-02 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24, 2016
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2BOU
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![BU of 2bou by Molmil](/molmil-images/mine/2bou) | EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium. | Descriptor: | BARIUM ION, CACODYLATE ION, CALCIUM ION, ... | Authors: | Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M. | Deposit date: | 2005-04-14 | Release date: | 2006-10-18 | Last modified: | 2017-01-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55. J.Biol.Chem., 282, 2007
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2BO2
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![BU of 2bo2 by Molmil](/molmil-images/mine/2bo2) | EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium. | Descriptor: | CACODYLATE ION, CALCIUM ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR | Authors: | Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M. | Deposit date: | 2005-04-07 | Release date: | 2006-08-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55. J.Biol.Chem., 282, 2007
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2BOX
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![BU of 2box by Molmil](/molmil-images/mine/2box) | EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium. | Descriptor: | CACODYLATE ION, CHLORIDE ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR, ... | Authors: | Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M. | Deposit date: | 2005-04-14 | Release date: | 2006-10-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55. J.Biol.Chem., 282, 2007
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1APJ
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![BU of 1apj by Molmil](/molmil-images/mine/1apj) | NMR STUDY OF THE TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-LIKE DOMAIN (TB MODULE/8-CYS DOMAIN), NMR, 21 STRUCTURES | Descriptor: | FIBRILLIN | Authors: | Yuan, X, Downing, A.K, Knott, V, Handford, P.A. | Deposit date: | 1997-07-22 | Release date: | 1998-01-28 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils. EMBO J., 16, 1997
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1TOZ
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![BU of 1toz by Molmil](/molmil-images/mine/1toz) | NMR structure of the human NOTCH-1 ligand binding region | Descriptor: | Neurogenic locus notch homolog protein 1 | Authors: | Hambleton, S, Valeyev, N.Y, Muranyi, A, Knott, V, Werner, J.M, Mcmichael, A.J, Handford, P.A, Downing, A.K. | Deposit date: | 2004-06-15 | Release date: | 2004-10-12 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Structural and functional properties of the human notch-1 ligand binding region STRUCTURE, 12, 2004
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5MS9
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![BU of 5ms9 by Molmil](/molmil-images/mine/5ms9) | |
1EMN
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![BU of 1emn by Molmil](/molmil-images/mine/1emn) | NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE | Descriptor: | CALCIUM ION, FIBRILLIN | Authors: | Downing, A.K, Campbell, I.D, Handford, P.A. | Deposit date: | 1996-08-05 | Release date: | 1996-12-23 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Cell(Cambridge,Mass.), 85, 1996
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1EMO
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![BU of 1emo by Molmil](/molmil-images/mine/1emo) | NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 22 STRUCTURES | Descriptor: | CALCIUM ION, FIBRILLIN | Authors: | Downing, A.K, Campbell, I.D, Handford, P.A. | Deposit date: | 1996-08-05 | Release date: | 1996-12-23 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Cell(Cambridge,Mass.), 85, 1996
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1UZK
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![BU of 1uzk by Molmil](/molmil-images/mine/1uzk) | Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, Ca bound to cbEGF23 domain only | Descriptor: | CALCIUM ION, FIBRILLIN-1 | Authors: | Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I. | Deposit date: | 2004-03-13 | Release date: | 2006-05-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization Structure, 12, 2004
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1UZP
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![BU of 1uzp by Molmil](/molmil-images/mine/1uzp) | Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, Sm bound form cbEGF23 domain only. | Descriptor: | FIBRILLIN-1, SAMARIUM (III) ION | Authors: | Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I. | Deposit date: | 2004-03-15 | Release date: | 2004-04-08 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization Structure, 12, 2004
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1UZJ
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![BU of 1uzj by Molmil](/molmil-images/mine/1uzj) | Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, holo form. | Descriptor: | CALCIUM ION, FIBRILLIN-1 | Authors: | Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I. | Deposit date: | 2004-03-12 | Release date: | 2004-04-08 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization Structure, 12, 2004
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1UZQ
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![BU of 1uzq by Molmil](/molmil-images/mine/1uzq) | Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, apo form cbEGF23 domain only. | Descriptor: | FIBRILLIN-1 | Authors: | Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I. | Deposit date: | 2004-03-15 | Release date: | 2004-04-08 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization Structure, 12, 2004
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5MWF
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![BU of 5mwf by Molmil](/molmil-images/mine/5mwf) | Human Jagged2 C2-EGF2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MVX
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![BU of 5mvx by Molmil](/molmil-images/mine/5mvx) | Human DLL4 C2-EGF3 | Descriptor: | Delta-like protein 4, alpha-L-fucopyranose | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-17 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MW7
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![BU of 5mw7 by Molmil](/molmil-images/mine/5mw7) | Human Jagged2 C2-EGF3 | Descriptor: | Protein jagged-2, alpha-L-fucopyranose | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MWB
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![BU of 5mwb by Molmil](/molmil-images/mine/5mwb) | Human Notch-2 EGF11-13 | Descriptor: | CALCIUM ION, Neurogenic locus notch homolog protein 2, alpha-L-fucopyranose, ... | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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5MW5
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![BU of 5mw5 by Molmil](/molmil-images/mine/5mw5) | Human Jagged2 C2-EGF2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Protein jagged-2 | Authors: | Suckling, R.J, Handford, P.A, Lea, S.M. | Deposit date: | 2017-01-18 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. EMBO J., 36, 2017
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1KSQ
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![BU of 1ksq by Molmil](/molmil-images/mine/1ksq) | NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1 | Descriptor: | LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 1 | Authors: | Lack, J, O'leary, J.M, Knott, V, Yuan, X, Rifkin, D.B, Handford, P.A, Downing, A.K. | Deposit date: | 2002-01-14 | Release date: | 2003-08-26 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Third TB Domain from LTBP1 Provides Insight into Assembly
of the Large Latent Complex that Sequesters Latent TGF-beta. J.Mol.Biol., 334, 2003
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1HJ7
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![BU of 1hj7 by Molmil](/molmil-images/mine/1hj7) | NMR study of a pair of LDL receptor Ca2+ binding epidermal growth factor-like domains, 20 structures | Descriptor: | CALCIUM ION, LDL RECEPTOR | Authors: | Saha, S, Handford, P.A, Campbell, I.D, Downing, A.K. | Deposit date: | 2001-01-09 | Release date: | 2001-07-11 | Last modified: | 2018-02-14 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Ldl Receptor Egf-Ab Pair: A Paradigm for the Assembly of Tandem Calcium Binding Egf Domains Structure, 9, 2001
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1LMJ
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![BU of 1lmj by Molmil](/molmil-images/mine/1lmj) | NMR Study of the Fibrillin-1 cbEGF12-13 Pair of Ca2+ Binding Epidermal Growth Factor-like Domains | Descriptor: | CALCIUM ION, fibrillin 1 | Authors: | Smallridge, R.S, Whiteman, P, Werner, J.M, Campbell, I.D, Handford, P.A, Downing, A.K. | Deposit date: | 2002-05-02 | Release date: | 2003-04-29 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution Structure and Dynamics of a Calcium Binding Epidermal Growth
Factor-like Domain Pair from the Neonatal Region of Human Fibrillin-1. J.Biol.Chem., 278, 2003
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