1GO1
 
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1TN5
 | | Structure of bacterorhodopsin mutant K41P | | Descriptor: | Bacteriorhodopsin, RETINAL | | Authors: | Yohannan, S, Yang, D, Faham, S, Boulting, G, Whitelegge, J, Bowie, J.U. | | Deposit date: | 2004-06-11 | | Release date: | 2004-10-19 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Proline substitutions are not easily accommodated in a membrane protein
J.Mol.Biol., 341, 2004
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2A0A
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2HDI
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3SKY
 | | 2.1A crystal structure of the phosphate bound ATP binding domain of Archaeoglobus fulgidus COPB | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Copper-exporting P-type ATPase B, PHOSPHATE ION | | Authors: | Jayakanthan, S, Roberts, S.A, Weichsel, A, Arguello, J.M, McEvoy, M.M. | | Deposit date: | 2011-06-23 | | Release date: | 2012-06-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle.
Biosci.Rep., 32, 2012
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7FAD
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2F7I
 | | Human transthyretin (TTR) complexed with diflunisal analogues- TTR. 2',6'-Difluorobiphenyl-4-carboxylic Acid | | Descriptor: | 2',6'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACID, Transthyretin | | Authors: | Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C. | | Deposit date: | 2005-11-30 | | Release date: | 2005-12-13 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis.
J.Med.Chem., 47, 2004
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1YM4
 | | Crystal structure of human beta secretase complexed with NVP-AMK640 | | Descriptor: | Beta-secretase 1, NVP-AMK640 INHIBITOR | | Authors: | Hanessian, S, Yun, H, Hou, Y, Yang, G, Bayrakdarian, M, Therrien, E, Moitessier, N, Roggo, S, Veenstra, S. | | Deposit date: | 2005-01-20 | | Release date: | 2006-01-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
J.Med.Chem., 48, 2005
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1QF5
 | | DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE | | Descriptor: | (C8-S)-HYDANTOCIDIN 5'-PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hanessian, S, Lu, P.-P, Sanceau, J.-Y, Chemla, P, Prade, L, Gohda, K, Cowan-Jacob, S.W, Fonne-Pfister, R. | | Deposit date: | 1999-04-06 | | Release date: | 1999-12-02 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | An enzyme-bound bisubstrate hybrid inhibitor of adenylosuccinate synthetase
Angew.Chem.Int.Ed.Engl., 38, 1999
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1QWV
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2K9U
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1YM2
 | | Crystal structure of human beta secretase complexed with NVP-AUR200 | | Descriptor: | Beta-secretase 1, NVP-AUR200 INHIBITOR | | Authors: | Hanessian, S, Yun, H, Hou, Y, Yang, G, Bayrakdarian, M, Therrien, E, Moitessier, N, Roggo, S, Veenstra, S. | | Deposit date: | 2005-01-20 | | Release date: | 2006-01-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
J.Med.Chem., 48, 2005
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1F31
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2HDF
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2FLM
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2ETF
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2EUI
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2FBR
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1SE2
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1R9Y
 | | Bacterial cytosine deaminase D314A mutant. | | Descriptor: | Cytosine deaminase, FE (III) ION, GLYCEROL, ... | | Authors: | Mahan, S.D, Ireton, G.C, Stoddard, B.L, Black, M.E. | | Deposit date: | 2003-10-31 | | Release date: | 2004-10-05 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Protein Eng.Des.Sel., 17, 2004
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2J5A
 | | Folding of S6 structures with divergent amino-acid composition: pathway flexibility within partly overlapping foldons | | Descriptor: | 30S RIBOSOMAL PROTEIN S6, SODIUM ION | | Authors: | Hansson, S, Olofsson, L, Hedberg, L, Oliveberg, M, Logan, D.T. | | Deposit date: | 2006-09-13 | | Release date: | 2006-10-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Folding of S6 Structures with Divergent Amino Acid Composition: Pathway Flexibility within Partly Overlapping Foldons.
J.Mol.Biol., 365, 2007
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3PYD
 | | crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis | | Descriptor: | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, GLYCEROL | | Authors: | Shan, S, Chen, X.H, Liu, T, Zhao, H.C, Rao, Z.H, Lou, Z.Y. | | Deposit date: | 2010-12-13 | | Release date: | 2012-01-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | The Structural Basis for anti-TB Drug Discovery targeting of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis
To be Published
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1S4Q
 | | Crystal Structure of Guanylate Kinase from Mycobacterium tuberculosis (Rv1389) | | Descriptor: | CHLORIDE ION, FORMIC ACID, Guanylate kinase | | Authors: | Chan, S, Sawaya, M.R, Perry, L.J, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2004-01-16 | | Release date: | 2004-01-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Crystal Structure of Guanylate Kinase from Mycobacterium tuberculosis
To be Published
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3PYG
 | | Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) in complex with ADP | | Descriptor: | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-DIPHOSPHATE | | Authors: | Shan, S, Chen, X.H, Liu, T, Zhao, H.C, Rao, Z.H, Lou, Z.Y. | | Deposit date: | 2010-12-13 | | Release date: | 2012-01-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | The Structural Basis for anti-TB Drug Discovery targeting of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis
To be Published
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2ZP6
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