1QF5

DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE

Summary for 1QF5

• Entry DOI: 10.2210/pdb1qf5/pdb
• Related: 1QF4
• Descriptor: PROTEIN (ADENYLOSUCCINATE SYNTHETASE), PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: purine biosynthesis, synthetase, gtp-binding, gtp-hydrolysing enzymes, ligase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 48291.38

Authors

Hanessian, S.,Lu, P.-P.,Sanceau, J.-Y.,Chemla, P.,Prade, L.,Gohda, K.,Cowan-Jacob, S.W.,Fonne-Pfister, R. (deposition date: 1999-04-06, release date: 1999-12-02, Last modification date: 2023-08-16)

Primary citation

Hanessian, S.,Lu, P.P.,Sanceau, J.Y.,Chemla, P.,Gohda, K.,Fonne-Pfister, R.,Prade, L.,Cowan-Jacob, S.W.
An enzyme-bound bisubstrate hybrid inhibitor of adenylosuccinate synthetase
Angew.Chem.Int.Ed.Engl., 38:3159-3162, 1999

PubMed Abstract: Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.

PubMed: 10556888
DOI: 10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO;2-2

Experimental method

X-RAY DIFFRACTION (2 Å)