1QF4

DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE

Summary for 1QF4

Entry DOI	10.2210/pdb1qf4/pdb
Descriptor	PROTEIN (ADENYLOSUCCINATE SYNTHETASE), PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	purine biosynthesis, synthetase, gtp-binding, gtp-hydrolysing enzymes, ligase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	48291.38
Authors	Hanessian, S.,Lu, P.-P.,Sanceau, J.-Y.,Chemla, P.,Gohda, K.,Fonne-Pfister, R.,Prade, L.,Cowan-Jacob, S.W. (deposition date: 1999-04-06, release date: 1999-12-02, Last modification date: 2023-08-16)
Primary citation	Hanessian, S.,Lu, P.P.,Sanceau, J.Y.,Chemla, P.,Gohda, K.,Fonne-Pfister, R.,Prade, L.,Cowan-Jacob, S.W. An enzyme-bound bisubstrate hybrid inhibitor of adenylosuccinate synthetase Angew.Chem.Int.Ed.Engl., 38:3159-3162, 1999 Cited by PubMed: 10556888 DOI: 10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO;2-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation