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PDB: 1527 results

3LBS
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BU of 3lbs by Molmil
Crystal structure of the cytoplasmic tail of (pro)renin receptor as a MBP fusion (Maltose-bound form)
Descriptor: Maltose-binding periplasmic protein, Renin receptor, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Zhang, Y, Garavito, R.M.
Deposit date:2010-01-08
Release date:2011-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural analysis of the intracellular domain of (pro)renin receptor fused to maltose-binding protein.
Biochem.Biophys.Res.Commun., 407, 2011
7K65
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BU of 7k65 by Molmil
Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside, ...
Authors:Zhang, Y, Bulkley, D.P, Liang, J, Manglik, A, Cheng, Y, Beachy, P.A.
Deposit date:2020-09-18
Release date:2021-03-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.
Proc.Natl.Acad.Sci.USA, 117, 2020
2MNY
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BU of 2mny by Molmil
NMR Structure of KDM5B PHD1 finger
Descriptor: Lysine-specific demethylase 5B, ZINC ION
Authors:Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C.
Deposit date:2014-04-16
Release date:2014-08-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Protein Cell, 5, 2014
3NTP
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BU of 3ntp by Molmil
Human Pin1 complexed with reduced amide inhibitor
Descriptor: (2R)-2-(acetylamino)-3-[(2S)-2-{[2-(1H-indol-3-yl)ethyl]carbamoyl}pyrrolidin-1-yl]propyl dihydrogen phosphate, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Authors:Zhang, Y.
Deposit date:2010-07-05
Release date:2012-01-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.762 Å)
Cite:A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state.
Biochemistry, 50, 2011
2MNZ
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BU of 2mnz by Molmil
NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa)
Descriptor: H3K4me0, Lysine-specific demethylase 5B, ZINC ION
Authors:Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C.
Deposit date:2014-04-16
Release date:2014-08-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Protein Cell, 5, 2014
3ZEE
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BU of 3zee by Molmil
Electron cyro-microscopy helical reconstruction of Par-3 N terminal domain
Descriptor: PARTITIONING DEFECTIVE 3 HOMOLOG
Authors:Zhang, Y, Wang, W, Chen, J, Zhang, K, Gao, F, Gong, W, Zhang, M, Sun, F, Feng, W.
Deposit date:2012-12-05
Release date:2013-10-16
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structural Insights Into the Intrinsic Self-Assembly of Par-3 N-Terminal Domain.
Structure, 21, 2013
4R7H
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BU of 4r7h by Molmil
Crystal structure of FMS KINASE domain with a small molecular inhibitor, PLX3397
Descriptor: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine, Macrophage colony-stimulating factor 1 receptor
Authors:Zhang, Y, Zhang, K, Zhang, C.
Deposit date:2014-08-27
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8001 Å)
Cite:Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.
N Engl J Med, 373, 2015
2GHQ
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BU of 2ghq by Molmil
CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II
Descriptor: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, DNA-directed RNA polymerase II largest subunit, MAGNESIUM ION
Authors:Zhang, Y, Noel, J.P.
Deposit date:2006-03-27
Release date:2006-12-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.
Mol.Cell, 24, 2006
6O3Y
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BU of 6o3y by Molmil
Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM3
Descriptor: CHLORIDE ION, Helicase SEN1, Protein NRD1
Authors:Zhang, Y, Tong, L.
Deposit date:2019-02-27
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.
Structure, 27, 2019
1TGE
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BU of 1tge by Molmil
The structure of immature Dengue virus at 12.5 angstrom
Descriptor: envelope glycoprotein
Authors:Zhang, Y, Zhang, W, Ogata, S, Clements, D, Strauss, J.H, Baker, T.S, Kuhn, R.J, Rossmann, M.G.
Deposit date:2004-05-28
Release date:2004-09-28
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (12.5 Å)
Cite:Conformational changes of the flavivirus e glycoprotein.
Structure, 12, 2004
3LZC
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BU of 3lzc by Molmil
Crystal structure of Dph2 from Pyrococcus horikoshii
Descriptor: Dph2
Authors:Zhang, Y, Zhu, X, Torelli, A.T, Lee, M, Dzikovski, B, Koralewski, R.M, Wang, E, Freed, J, Krebs, C, Lin, H, Ealick, S.E.
Deposit date:2010-03-01
Release date:2010-06-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.261 Å)
Cite:Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
Nature, 465, 2010
1TG8
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BU of 1tg8 by Molmil
The structure of Dengue virus E glycoprotein
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, envelope glycoprotein
Authors:Zhang, Y, Zhang, W, Ogata, S, Clements, D, Strauss, J.H, Baker, T.S, Rossmann, M.G.
Deposit date:2004-05-28
Release date:2004-09-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Conformational changes of the flavivirus e glycoprotein
Structure, 12, 2004
2GHT
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BU of 2ght by Molmil
CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II
Descriptor: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, DNA-directed RNA polymerase II largest subunit, MAGNESIUM ION
Authors:Zhang, Y, Noel, J.P.
Deposit date:2006-03-27
Release date:2006-12-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1.
Mol.Cell, 24, 2006
3PWM
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BU of 3pwm by Molmil
HIV-1 Protease Mutant L76V with Darunavir
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETATE ION, CHLORIDE ION, ...
Authors:Zhang, Y, Weber, I.T.
Deposit date:2010-12-08
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic Contacts.
Biochemistry, 50, 2011
3PQE
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BU of 3pqe by Molmil
Crystal structure of L-lactate dehydrogenase from Bacillus subtilis with H171C mutation
Descriptor: L-lactate dehydrogenase
Authors:Zhang, Y, Garavito, R.M.
Deposit date:2010-11-26
Release date:2011-12-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of L-lactate dehydrogenase from Bacillus subtilis with H171C mutation
To be Published
6XGZ
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BU of 6xgz by Molmil
Crystal structure of E. coli MlaFB ABC transport subunits in the monomeric state
Descriptor: 1,2-ETHANEDIOL, ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, ...
Authors:Chang, Y, Bhabha, G, Ekiert, D.C.
Deposit date:2020-06-18
Release date:2020-07-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation.
Elife, 9, 2020
4G7O
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BU of 4g7o by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA
Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.993 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
4G7Z
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BU of 4g7z by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at template-strand position +1
Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*(BRU)P*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2012-07-20
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.815 Å)
Cite:Structural basis of transcription initiation.
Science, 338, 2012
7KHK
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BU of 7khk by Molmil
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX9486 (bezuclastinib) in the DFG-in state
Descriptor: 4,5-dimethyl-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-3-carboxamide, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y.
Deposit date:2020-10-21
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
Jama Oncol, 7, 2021
7KHJ
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BU of 7khj by Molmil
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX8512 in the DFG-in state
Descriptor: 2-phenyl-5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y.
Deposit date:2020-10-21
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
Jama Oncol, 7, 2021
7KHG
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BU of 7khg by Molmil
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX3397
Descriptor: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y.
Deposit date:2020-10-21
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
Jama Oncol, 7, 2021
5TIG
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BU of 5tig by Molmil
CRYSTAL STRUCTURE OF 4-OXALOCROTONATE TAUTOMERASE INACTIVATED BY BrHPD
Descriptor: (3E)-5-hydroxy-2-oxopent-3-enoic acid, 2-hydroxymuconate tautomerase
Authors:Zhang, Y, Li, W, Stack, T.
Deposit date:2016-10-02
Release date:2018-02-21
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates.
Biochemistry, 57, 2018
4HVS
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BU of 4hvs by Molmil
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647
Descriptor: 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine, Mast/stem cell growth factor receptor Kit
Authors:Zhang, Y, Zhang, C.
Deposit date:2012-11-06
Release date:2013-03-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Proc.Natl.Acad.Sci.USA, 110, 2013
7F7I
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BU of 7f7i by Molmil
Stapled Peptide Inhibitor in complex with PSD95 GK domain
Descriptor: ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2, Disks large homolog 4
Authors:Shang, Y, Huang, X, Li, X, Zhang, M.
Deposit date:2021-06-29
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.595 Å)
Cite:Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
8J0T
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BU of 8j0t by Molmil
Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in the apo-form
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ...
Authors:Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H.
Deposit date:2023-04-11
Release date:2024-05-22
Last modified:2024-08-21
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587.
Nature, 631, 2024

224004

数据于2024-08-21公开中

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