8DJU
| Cytosolic ascorbate peroxidase from Sorghum bicolor - bicyclic dehydroascorbic acid complex | Descriptor: | (3aS,6S,6aR)-3,3,3a,6-tetrahydroxytetrahydrofuro[3,2-b]furan-2(3H)-one (non-preferred name), L-ascorbate peroxidase, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Zhang, B, Kang, C. | Deposit date: | 2022-07-01 | Release date: | 2023-01-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A sorghum ascorbate peroxidase with four binding sites has activity against ascorbate and phenylpropanoids. Plant Physiol., 192, 2023
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8FET
| Flavanone 4-Reductase from Sorghum bicolor-NADP(H) complex | Descriptor: | 3-deoxyanthocyanidin synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zhang, B, Kang, C. | Deposit date: | 2022-12-06 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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8FEV
| Flavanone 4-Reductase from Sorghum bicolor-NADP(H) and dihydroquercetin complex | Descriptor: | (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, 3-deoxyanthocyanidin synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Zhang, B, Kang, C. | Deposit date: | 2022-12-06 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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8FIO
| Hypothetical anthocyanidin reductase from Sorghum bicolor-NADP(H) and naringenin complex | Descriptor: | Epimerase domain-containing protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NARINGENIN | Authors: | Zhang, B, Kang, C. | Deposit date: | 2022-12-16 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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8FEW
| Flavanone 4-Reductase from Sorghum bicolor-naringenin complex | Descriptor: | 3-deoxyanthocyanidin synthase, NARINGENIN, SULFATE ION | Authors: | Zhang, B, Kang, C. | Deposit date: | 2022-12-06 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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8FIP
| Hypothetical anthocyanidin reducatase from Sorghum bicolor- NADP+ complex | Descriptor: | Epimerase domain-containing protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zhang, B, Kang, C. | Deposit date: | 2022-12-16 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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8FEU
| Flavanone 4-Reductase from Sorghum bicolor-NADP(H) and naringenin complex | Descriptor: | 3-deoxyanthocyanidin synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NARINGENIN, ... | Authors: | Zhang, B, Kang, C. | Deposit date: | 2022-12-06 | Release date: | 2023-09-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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6M03
| The crystal structure of COVID-19 main protease in apo form | Descriptor: | 3C-like proteinase | Authors: | Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Rao, Z. | Deposit date: | 2020-02-19 | Release date: | 2020-03-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 119, 2022
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8KIH
| PhmA, a type I diterpene synthase without NST/DTE motif | Descriptor: | (2Z,6E,10E)-2-fluoro-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate, MAGNESIUM ION, diterpene synthase, ... | Authors: | Zhang, B, Ge, H.M, Zhu, A, Zhang, Y. | Deposit date: | 2023-08-23 | Release date: | 2023-10-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biosynthesis of Phomactin Platelet Activating Factor Antagonist Requires a Two-Enzyme Cascade. Angew.Chem.Int.Ed.Engl., 62, 2023
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8KI5
| PhmA, a type I diterpene synthase without NST/DTE motif | Descriptor: | (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, PhmA | Authors: | Zhang, B, Ge, H.M, Zhu, A, Zhang, Y. | Deposit date: | 2023-08-22 | Release date: | 2023-10-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Biosynthesis of Phomactin Platelet Activating Factor Antagonist Requires a Two-Enzyme Cascade. Angew.Chem.Int.Ed.Engl., 62, 2023
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6VBY
| Cinnamate 4-hydroxylase (C4H1) from Sorghum bicolor | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cinnamic acid 4-hydroxylase, GLYCEROL, ... | Authors: | Zhang, B, Kang, C, Lewis, K.M. | Deposit date: | 2019-12-19 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and Function of the Cytochrome P450 Monooxygenase Cinnamate 4-hydroxylase fromSorghum bicolor. Plant Physiol., 183, 2020
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7XSI
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6M0K
| The crystal structure of COVID-19 main protease in complex with an inhibitor 11b | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-(3-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | Authors: | Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Liu, H, Rao, Z, Jiang, H. | Deposit date: | 2020-02-22 | Release date: | 2020-04-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.504 Å) | Cite: | Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science, 368, 2020
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4L1W
| Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 in Complex with NADP+ and Progesterone | Descriptor: | Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... | Authors: | Zhang, B, Hu, X.-J, Lin, S.-X. | Deposit date: | 2013-06-03 | Release date: | 2014-04-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Human 3-alpha hydroxysteroid dehydrogenase type 3 (3 alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20 alpha-HSD activity J.Steroid Biochem.Mol.Biol., 141, 2014
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7FE5
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7FE6
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7FE0
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3VBC
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7ZH0
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7WNX
| Cryo-EM structure of Mycobacterium smegmatis MmpL3 complexed with ST004 in lipid nanodiscs | Descriptor: | N-[2-(2-adamantylamino)ethyl]-1-[2,4-bis(fluoranyl)phenyl]-5-(4-chlorophenyl)-4-methyl-pyrazole-3-carboxamide, Trehalose monomycolate exporter MmpL3 | Authors: | Zhang, B, Hu, T, Yang, X, Liu, F, Rao, Z. | Deposit date: | 2022-01-20 | Release date: | 2022-08-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3. Structure, 30, 2022
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4L1X
| Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone | Descriptor: | Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... | Authors: | Zhang, B, Hu, X.-J, Lin, S.-X. | Deposit date: | 2013-06-03 | Release date: | 2014-04-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human 3-alpha hydroxysteroid dehydrogenase type 3 (3 alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20 alpha-HSD activity J.Steroid Biochem.Mol.Biol., 141, 2014
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8I16
| Crystal structure of the selenomethionine (SeMet)-derived Cas12g (D513A) mutant | Descriptor: | Cas12g, ZINC ION | Authors: | Zhang, B, Chen, J, Ye, Y.M, OuYang, S.Y. | Deposit date: | 2023-01-12 | Release date: | 2023-08-30 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structural transitions upon guide RNA binding and their importance in Cas12g-mediated RNA cleavage. Plos Genet., 19, 2023
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1IXV
| Crystal Structure Analysis of homolog of oncoprotein gankyrin, an interactor of Rb and CDK4/6 | Descriptor: | Probable 26S proteasome regulatory subunit p28 | Authors: | Padmanabhan, B, Adachi, N, Kataoka, K, Horikoshi, M. | Deposit date: | 2002-07-09 | Release date: | 2003-12-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6 J.BIOL.CHEM., 279, 2004
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7EXI
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7VRM
| crystal structure of BRD2-BD2 in complex with purine derivative | Descriptor: | Bromodomain-containing protein 2, THEOPHYLLINE | Authors: | Padmanabhan, B, Arole, A, Deshmukh, P, Ashok, S, Mathur, S. | Deposit date: | 2021-10-23 | Release date: | 2023-02-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family. Acta Crystallogr D Struct Biol, 79, 2023
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