7VRM
crystal structure of BRD2-BD2 in complex with purine derivative
Summary for 7VRM
| Entry DOI | 10.2210/pdb7vrm/pdb |
| Descriptor | Bromodomain-containing protein 2, THEOPHYLLINE (3 entities in total) |
| Functional Keywords | bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription-inhibitor complex, transcription/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 13884.80 |
| Authors | Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S.,Mathur, S. (deposition date: 2021-10-23, release date: 2023-02-01, Last modification date: 2023-11-29) |
| Primary citation | Arole, A.H.,Deshmukh, P.,Sridhar, A.,Mathur, S.,Mahalingaswamy, M.,Subramanya, H.,Dalavaikodihalli Nanjaiah, N.,Padmanabhan, B. Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family. Acta Crystallogr D Struct Biol, 79:758-774, 2023 Cited by PubMed: 37432115DOI: 10.1107/S2059798323005211 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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