7FE6

AvmM Catalyzes Macrocyclization in Alchivemycin A Biosynthesis

Summary for 7FE6

• Entry DOI: 10.2210/pdb7fe6/pdb
• Related: 7FE0 7FE5
• Descriptor: AvmM, CHLORIDE ION, Alchivemycin A, ... (4 entities in total)
• Functional Keywords: avmm, macrocyclization, michael addition, biosynthetic protein-inhibitor complex, biosynthetic protein/inhibitor
• Biological source: Streptomyces sp. NBRC 109436
• Total number of polymer chains: 3
• Total formula weight: 65914.85

Authors

Zhang, B.,Ge, H.M. (deposition date: 2021-07-19, release date: 2021-09-01, Last modification date: 2023-11-29)

• Primary citation: Zhu, H.J.,Zhang, B.,Wei, W.,Liu, S.H.,Xiang, L.,Zhu, J.,Jiao, R.H.,Igarashi, Y.,Bashiri, G.,Liang, Y.,Tan, R.X.,Ge, H.M.; AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis.; Nat Commun, 13:4499-4499, 2022; PubMed: 35922406; DOI: 10.1038/s41467-022-32088-4

Experimental method

X-RAY DIFFRACTION (2.5 Å)