4L1W

Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 in Complex with NADP+ and Progesterone

Summary for 4L1W

Entry DOI	10.2210/pdb4l1w/pdb
Related	4L1X
Descriptor	Aldo-keto reductase family 1 member C2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (5 entities in total)
Functional Keywords	alpha-beta barrel, human 3-alpha hsd3, akr, akr1c2, oxidoreductase, aldo-keto reductase, nadph
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (Potential): P52895
Total number of polymer chains	2
Total formula weight	76220.59
Authors	Zhang, B.,Hu, X.-J.,Lin, S.-X. (deposition date: 2013-06-03, release date: 2014-04-16, Last modification date: 2023-11-08)
Primary citation	Zhang, B.,Zhu, D.-W.,Hu, X.-J.,Zhou, M.,Shang, P.,Lin, S.-X. Human 3-alpha hydroxysteroid dehydrogenase type 3 (3 alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20 alpha-HSD activity J.Steroid Biochem.Mol.Biol., 141:135-143, 2014 Cited by PubMed: 24434280 DOI: 10.1016/j.jsbmb.2014.01.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation