6X7U
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1FXT
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![BU of 1fxt by Molmil](/molmil-images/mine/1fxt) | STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX | Descriptor: | UBIQUITIN, UBIQUITIN-CONJUGATING ENZYME E2-24 KDA | Authors: | Hamilton, K.S, Shaw, G.S, Williams, R.S, Huzil, J.T, McKenna, S, Ptak, C, Glover, M, Ellison, M.J. | Deposit date: | 2000-09-26 | Release date: | 2001-10-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail. Structure, 9, 2001
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6X7V
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7K95
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![BU of 7k95 by Molmil](/molmil-images/mine/7k95) | Crystal structure of human CPSF30 in complex with hFip1 | Descriptor: | Isoform 2 of Cleavage and polyadenylation specificity factor subunit 4, Pre-mRNA 3'-end-processing factor FIP1, ZINC ION | Authors: | Hamilton, K, Tong, L. | Deposit date: | 2020-09-28 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular mechanism for the interaction between human CPSF30 and hFip1. Genes Dev., 34, 2020
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1MZC
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![BU of 1mzc by Molmil](/molmil-images/mine/1mzc) | Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a | Descriptor: | 2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE, FARNESYL DIPHOSPHATE, Protein Farnesyltransferase alpha Subunit, ... | Authors: | deSolms, S.J, Ciccarone, T.M, MacTough, S.C, Shaw, A.W, Buser, C.A, Ellis-Hutchings, M, Fernandes, C, Hamilton, K.A, Huber, H.E, Kohl, N.E, Lobell, R.B, Robinson, R.G, Tsou, N.N, Walsh, E.S, Graham, S.L, Beese, L.S, Taylor, J.S. | Deposit date: | 2002-10-07 | Release date: | 2003-07-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents. J.Med.Chem., 46, 2003
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5DIL
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![BU of 5dil by Molmil](/molmil-images/mine/5dil) | Crystal structure of the effector domain of the NS1 protein from influenza virus B | Descriptor: | IODIDE ION, Non-structural protein 1 | Authors: | Guan, R, Hamilton, K, Ma, L, Montelione, G.T. | Deposit date: | 2015-09-01 | Release date: | 2016-08-10 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus. Structure, 24, 2016
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1YRS
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![BU of 1yrs by Molmil](/molmil-images/mine/1yrs) | Crystal structure of KSP in complex with inhibitor 1 | Descriptor: | 3-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... | Authors: | Cox, C.D, Breslin, M.J, Mariano, B.J, Coleman, P.J, Buser, C.A, Walsh, E.S, Hamilton, K, Kohl, N.E, Torrent, M, Yan, Y, Kuo, L.C, Hartman, G.D. | Deposit date: | 2005-02-04 | Release date: | 2005-04-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP BIOORG.MED.CHEM.LETT., 15, 2005
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6BM0
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![BU of 6bm0 by Molmil](/molmil-images/mine/6bm0) | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.8 A resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | Deposit date: | 2017-11-12 | Release date: | 2017-11-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BLY
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![BU of 6bly by Molmil](/molmil-images/mine/6bly) | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | Deposit date: | 2017-11-12 | Release date: | 2017-11-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DNH
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![BU of 6dnh by Molmil](/molmil-images/mine/6dnh) | Cryo-EM structure of human CPSF-160-WDR33-CPSF-30-PAS RNA complex at 3.4 A resolution | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*C)-3'), ... | Authors: | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | Deposit date: | 2018-06-06 | Release date: | 2018-06-27 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2M5O
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![BU of 2m5o by Molmil](/molmil-images/mine/2m5o) | Solution NMR Structure CTD domain of NFU1 Iron-Sulfur Cluster Scaffold Homolog from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR2876C | Descriptor: | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial | Authors: | Liu, G, Xiao, R, Janjua, H, Hamilton, K, Shastry, R, Kohan, E, Acton, T.B, Everett, J.K, Pederson, K, Huang, Y.J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG), Mitochondrial Protein Partnership (MPP) | Deposit date: | 2013-03-01 | Release date: | 2013-05-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure CTD domain of NFU1 Iron-Sulfur Cluster Scaffold Homolog from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR2876C To be Published
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2LUL
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![BU of 2lul by Molmil](/molmil-images/mine/2lul) | Solution NMR Structure of PH Domain of Tyrosine-protein kinase Tec from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR3504C | Descriptor: | Tyrosine-protein kinase Tec, ZINC ION | Authors: | Liu, G, Xiao, R, Janjua, H, Hamilton, K, Shastry, R, Kohan, E, Acton, T.B, Everett, J.K, Lee, H, Pederson, K, Huang, Y.J, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-06-15 | Release date: | 2012-08-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of PH Domain of Tyrosine-protein kinase Tec from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR3504C To be Published
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2N2U
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![BU of 2n2u by Molmil](/molmil-images/mine/2n2u) | Solution NMR Structure of DE NOVO DESIGNED Ferredoxin Fold PROTEIN sfr3, Northeast Structural Genomics Consortium (NESG) Target OR358 | Descriptor: | OR358 | Authors: | Liu, G, Lin, Y, Koga, N, Koga, R, Xiao, R, Janjua, H, Hamilton, K, Pederson, K, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-05-14 | Release date: | 2015-09-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of DE NOVO DESIGNED Ferredoxin Fold PROTEIN sfr3, Northeast Structural Genomics Consortium (NESG) Target OR358 To be Published
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2MA7
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![BU of 2ma7 by Molmil](/molmil-images/mine/2ma7) | Solution NMR Structure of Zinc finger protein Eos from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7992A | Descriptor: | ZINC ION, Zinc finger protein Eos | Authors: | Pulavarti, S.V, Mills, J.L, Wang, D, Jigabm, E, Hamilton, K, Xiao, R, Everett, J.K, Acton, T.B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-06-28 | Release date: | 2013-09-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Zinc finger protein Eos from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR7992A To be Published
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2M9X
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![BU of 2m9x by Molmil](/molmil-images/mine/2m9x) | Solution NMR Structure of Microtubule-associated serine/threonine-protein kinase 1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9151A | Descriptor: | Microtubule-associated serine/threonine-protein kinase 1 | Authors: | Xu, X, Eletsky, A, Shastry, R, Lee, D, Hamilton, K, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-06-20 | Release date: | 2013-07-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Microtubule-associated serine/threonine-protein kinase 1 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9151A To be Published
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2N2T
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![BU of 2n2t by Molmil](/molmil-images/mine/2n2t) | Solution NMR Structure of DE NOVO DESIGNED PROTEIN (FDA_60), Northeast Structural Genomics Consortium (NESG) Target OR303 | Descriptor: | OR303 | Authors: | Liu, G, Lin, Y, Koga, N, Koga, R, Xiao, R, Janjua, H, Hamilton, K, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-05-14 | Release date: | 2015-09-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of DE NOVO DESIGNED PROTEIN (FDA_60), Northeast Structural Genomics Consortium (NESG) Target OR303 To be Published
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2MTL
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![BU of 2mtl by Molmil](/molmil-images/mine/2mtl) | Solution NMR Structure of De novo designed FR55, Northeast Structural Genomics Consortium (NESG) Target OR109 | Descriptor: | De novo designed protein FR55 OR109 | Authors: | Liu, G, Koga, N, Koga, R, Xiao, R, Hamilton, K, Ciccosanti, C, Sahdev, S, Kohan, E, Acton, T.B, Kornhaber, G, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2014-08-19 | Release date: | 2014-10-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of De novo designed FR55, Northeast Structural Genomics Consortium (NESG) Target OR109 To be Published
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2LE1
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![BU of 2le1 by Molmil](/molmil-images/mine/2le1) | Solution NMR Structure of Tfu_2981 from Thermobifida fusca, Northeast Structural Genomics Consortium Target TfR85A | Descriptor: | Uncharacterized protein | Authors: | Pulavarti, S.V.S.R.K, Eletsky, A, Mills, J.L, Sukumaran, D.K, Wang, D, Ciccosanti, C, Hamilton, K, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Lee, H, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-06-03 | Release date: | 2011-06-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Tfu_2981 from Thermobifida fusca, Northeast Structural Genomics Consortium Target TfR85A To be Published
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2KTA
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![BU of 2kta by Molmil](/molmil-images/mine/2kta) | Solution NMR structure of a domain of protein A6KY75 from Bacteroides vulgatus, Northeast Structural Genomics target BvR106A | Descriptor: | Putative helicase | Authors: | Mills, J.L, Sukumaran, D.K, Sathyamoorthy, B, Belote, R.L, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Swapna, G.V.T, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-01-26 | Release date: | 2010-06-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of a domain of protein A6KY75 from Bacteroides vulgatus, Northeast Structural Genomics target BvR106A To be Published
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2KMM
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![BU of 2kmm by Molmil](/molmil-images/mine/2kmm) | Solution NMR structure of the TGS domain of PG1808 from Porphyromonas gingivalis. Northeast Structural Genomics Consortium Target PgR122A (418-481) | Descriptor: | Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase | Authors: | Yang, Y, Ramelot, T.A, Cort, J.R, Lee, D, Ciccosanti, C, Hamilton, K, Nair, R, Rost, B, Acton, T.B, Xiao, R, Swapna, G, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-07-31 | Release date: | 2009-11-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the TGS domain of PG1808 from
Porphyromonas gingivalis. Northeast Structural Genomics Consortium Target
PgR122A (418-481) To be Published
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2KL6
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![BU of 2kl6 by Molmil](/molmil-images/mine/2kl6) | Solution NMR structure of the CARDB domain of PF1109 from Pyrococcus furiosus. Northeast Structural Genomics Consortium target PfR193A | Descriptor: | Uncharacterized protein | Authors: | Aramini, J.M, Lee, D, Ciccosanti, C, Hamilton, K, Nair, R, Rost, B, Acton, T.B, Xiao, R, Swapna, G.V.T, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-06-30 | Release date: | 2009-08-25 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the CARDB domain of PF1109 from Pyrococcus furiosus. Northeast Structural Genomics Consortium target PfR193A To be Published
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2KFP
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![BU of 2kfp by Molmil](/molmil-images/mine/2kfp) | Solution NMR structure of PSPTO_3016 from Pseudomonas syringae. Northeast Structural Genomics Consortium target PsR293. | Descriptor: | PSPTO_3016 protein | Authors: | Feldmann, E.A, Ramelot, T.A, Zhao, L, Hamilton, K, Ciccosanti, C, Xiao, R, Nair, R, Everett, J.K, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-02-24 | Release date: | 2009-03-24 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Solution NMR and X-ray crystal structures of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopt a "double wing" DNA binding motif. J.Struct.Funct.Genom., 13, 2012
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2KT8
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![BU of 2kt8 by Molmil](/molmil-images/mine/2kt8) | Solution NMR structure of the CPE1231(468-535) protein from Clostridium perfringens, Northeast Structural Genomics Consortium Target CpR82B | Descriptor: | Probable surface protein | Authors: | Yang, Y, Ramelot, T.A, Lee, D, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-01-21 | Release date: | 2010-02-02 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the CPE1231(468-535) protein from Clostridium perfringens, Northeast Structural Genomics Consortium Target CpR82B To be Published
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2KVO
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![BU of 2kvo by Molmil](/molmil-images/mine/2kvo) | Solution NMR structure of Photosystem II reaction center Psb28 protein from Synechocystis sp.(strain PCC 6803), Northeast Structural Genomics Consortium Target SgR171 | Descriptor: | Photosystem II reaction center psb28 protein | Authors: | Yang, Y, Ramelot, T.A, Cort, J.R, Wang, D, Ciccosanti, C, Hamilton, K, Nair, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-03-22 | Release date: | 2010-04-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of photosystem II reaction center protein Psb28 from Synechocystis sp. Strain PCC 6803. Proteins, 79, 2011
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2KQ8
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![BU of 2kq8 by Molmil](/molmil-images/mine/2kq8) | Solution NMR structure of a domain from BT9727_4915 from Bacillus thuringiensis, Northeast Structural Genomics Consortium Target BuR95A | Descriptor: | Cell wall hydrolase | Authors: | He, Y, Mills, J.L, Wu, Y, Eletsky, A, Wang, H, Ciccosanti, C, Hamilton, K, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-10-30 | Release date: | 2010-01-26 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of a domain from BT9727_4915 from Bacillus thuringiensis, Northeast Structural Genomics Consortium Target BuR95A To be Published
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