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PDB: 134 results

5NWB
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BU of 5nwb by Molmil
Crystal structure of TNKS2 in complex with 2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-3,4-dihydroquinazolin-4-one
Descriptor: 2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-05-05
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
5NXE
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BU of 5nxe by Molmil
Crystal structure of TNKS2 in complex with 2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-1,2,3,4-tetrahydroquinazolin-4-one
Descriptor: 2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-2,3-dihydro-1~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-05-10
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
5NWC
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BU of 5nwc by Molmil
Crystal structure of TNKS2 in complex with 2-(2-aminophenyl)-3,4-dihydroquinazolin-4-one
Descriptor: 2-(2-aminophenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-05-05
Release date:2018-05-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
5NVF
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BU of 5nvf by Molmil
Crystal structure of TNKS2 in complex with 2-[4-(pyridin-2-yl)phenyl]-3,4-dihydroquinazolin-4-one
Descriptor: 2-(4-pyridin-2-ylphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-05-04
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
5NSX
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BU of 5nsx by Molmil
Crystal structure of TNKS2 in complex with 2-(1H-indazol-5-yl)-3,4-dihydroquinazolin-4-one
Descriptor: 2-(2~{H}-indazol-5-yl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-04-27
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
5NT4
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BU of 5nt4 by Molmil
Crystal structure of TNKS2 in complex with 2-[4-(morpholin-4-yl)phenyl]-3,4-dihydroquinazolin-4-one
Descriptor: 2-[4-morpholin-4-yl]-3,4-dihydroquinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-04-27
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
5NUT
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BU of 5nut by Molmil
Crystal structure of TNKS2 in complex with 2-[4-(propan-2-yloxy)phenyl]-3,4-dihydroquinazolin-4-one
Descriptor: 2-(4-propan-2-yloxyphenyl)-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-05-02
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
5NWG
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BU of 5nwg by Molmil
Crystal structure of TNKS2 in complex with 7-chloro-2-{4-[(2-hydroxyethyl)(methyl)amino]phenyl}-3,4-dihydroquinazolin-4-one
Descriptor: 7-chloranyl-2-[4-[2-hydroxyethyl(methyl)amino]phenyl]-3~{H}-quinazolin-4-one, GLYCEROL, SULFATE ION, ...
Authors:Nkizinkiko, Y, Haikarainen, T, Lehtio, L.
Deposit date:2017-05-05
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Sci Rep, 8, 2018
4HKK
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BU of 4hkk by Molmil
Complex structure of human tankyrase 2 with apigenin
Descriptor: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLK
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BU of 4hlk by Molmil
Crystal structure of Tankyrase 2 in complex with 4'-methylflavone
Descriptor: 2-(4-methylphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLM
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BU of 4hlm by Molmil
Crystal structure of Tankyrase 2 in complex with 3',4'-Dihydroxyflavone
Descriptor: 2-(3,4-dihydroxyphenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HMH
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BU of 4hmh by Molmil
Crystal structure of tankyrase 2 in complex with 7,3-dihydroxyflavone
Descriptor: 7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-18
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLG
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BU of 4hlg by Molmil
Crystal structure of Tankyrase 2 in complex with 3'-hydroxyflavone
Descriptor: 2-(3-hydroxyphenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HLH
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BU of 4hlh by Molmil
Crystal structure of Tankyrase 2 in complex with 4'-fluoroflavone
Descriptor: 2-(4-fluorophenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-17
Release date:2012-10-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HL5
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BU of 4hl5 by Molmil
Complex structure of human tankyrase 2 with 7-hydroxy -4'-methoxyflavone
Descriptor: 7-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-16
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4HKN
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BU of 4hkn by Molmil
Complex structure of human tankyrase 2 with luteolin
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SULFATE ION, Tankyrase-2, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2012-10-15
Release date:2012-10-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem., 56, 2013
4KZL
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BU of 4kzl by Molmil
Crystal structure of human tankyrase 2 in complex with 4'-fluoro flavone
Descriptor: 2-(4-fluorophenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-05-30
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L0S
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BU of 4l0s by Molmil
Tankyrase 2 in complex with 4'-cyano flavone
Descriptor: 4-(4-oxo-4H-chromen-2-yl)benzonitrile, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-01
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L10
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BU of 4l10 by Molmil
Tankyrase 2 in complex with 4'-methoxy flavone
Descriptor: 2-(4-methoxyphenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-01
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L0I
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BU of 4l0i by Molmil
Tankyrase 2 catalytic domain in complex with ethyl 4-(4-oxo-4H-chromen-2-yl)benzoate
Descriptor: SULFATE ION, Tankyrase-2, ZINC ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-05-31
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L0T
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BU of 4l0t by Molmil
Tankyrase 2 in complex with 4'-nitro flavone
Descriptor: 2-(4-nitrophenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-01
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L2G
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BU of 4l2g by Molmil
Tankyrase 2 in complex with 6- fluoro flavone
Descriptor: 6-fluoro-2-phenyl-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-04
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L0B
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BU of 4l0b by Molmil
Tankyrase 2 in complex with 4'-dimethylamino flavone
Descriptor: 2-[4-(dimethylamino)phenyl]-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-05-31
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L0V
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BU of 4l0v by Molmil
Tankyrase 2 in complex with 4'-chloro flavone
Descriptor: 2-(4-chlorophenyl)-4H-chromen-4-one, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-01
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013
4L33
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BU of 4l33 by Molmil
Tankyrase 2 in complex with cyanomethyl 4-(4-oxo-4H-chromen-2-yl)benzoate
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, SULFATE ION, ...
Authors:Narwal, M, Haikarainen, T, Lehtio, L.
Deposit date:2013-06-05
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
J.Med.Chem., 56, 2013

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数据于2024-06-12公开中

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