5NVE

Crystal structure of TNKS2 in complex with 2-(4-ethoxyphenyl)-3,4-dihydroquinazolin-4-one

Summary for 5NVE

• Entry DOI: 10.2210/pdb5nve/pdb
• Descriptor: Tankyrase-2, SULFATE ION, ZINC ION, ... (7 entities in total)
• Functional Keywords: tankyrase, inhibitor, artd6, parp5b, adp-ribosyltransferase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 55867.37

Authors

Nkizinkiko, Y.,Haikarainen, T.,Lehtio, L. (deposition date: 2017-05-04, release date: 2018-03-14, Last modification date: 2024-01-17)

• Primary citation: Nkizinkiko, Y.,Desantis, J.,Koivunen, J.,Haikarainen, T.,Murthy, S.,Sancineto, L.,Massari, S.,Ianni, F.,Obaji, E.,Loza, M.I.,Pihlajaniemi, T.,Brea, J.,Tabarrini, O.,Lehtio, L.; 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.; Sci Rep, 8:1680-1680, 2018; PubMed: 29374194; DOI: 10.1038/s41598-018-19872-3

Experimental method

X-RAY DIFFRACTION (1.5 Å)